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Down-regulation of canonical and up-regulation of non-canonical Wnt signalling in the carcinogenic process of squamous cell lung carcinoma.

Bartis D, Csongei V, Weich A, Kiss E, Barko S, Kovacs T, Avdicevic M, D'Souza VK, Rapp J, Kvell K, Jakab L, Nyitrai M, Molnar TF, Thickett DR, Laszlo T, Pongracz JE.

PLoS One. 2013;8(3):e57393. doi: 10.1371/journal.pone.0057393.


Wnt5a is strongly expressed at the leading edge in non-melanoma skin cancer, forming active gradients, while canonical Wnt signalling is repressed.

Pourreyron C, Reilly L, Proby C, Panteleyev A, Fleming C, McLean K, South AP, Foerster J.

PLoS One. 2012;7(2):e31827. doi: 10.1371/journal.pone.0031827.


Increased Wnt5a in squamous cell lung carcinoma inhibits endothelial cell motility.

Rapp J, Kiss E, Meggyes M, Szabo-Meleg E, Feller D, Smuk G, Laszlo T, Sarosi V, Molnar TF, Kvell K, Pongracz JE.

BMC Cancer. 2016 Nov 23;16(1):915.


Wnt5a expression is associated with the tumor proliferation and the stromal vascular endothelial growth factor--an expression in non-small-cell lung cancer.

Huang CL, Liu D, Nakano J, Ishikawa S, Kontani K, Yokomise H, Ueno M.

J Clin Oncol. 2005 Dec 1;23(34):8765-73.


WNT-5A, but not matrix metalloproteinase 3 or beta-catenin protein, expression is related to early stages of lip carcinogenesis.

Xavier FC, Rodini CO, Ramalho LM, Mantesso A, Nunes FD.

J Oral Pathol Med. 2009 Oct;38(9):708-15. doi: 10.1111/j.1600-0714.2009.00756.x.


WNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma.

Li J, Ying J, Fan Y, Wu L, Ying Y, Chan AT, Srivastava G, Tao Q.

Cancer Biol Ther. 2010 Sep 15;10(6):617-24.


CAFET algorithm reveals Wnt/PCP signature in lung squamous cell carcinoma.

Hu Y, Galkin AV, Wu C, Reddy V, Su AI.

PLoS One. 2011;6(10):e25807. doi: 10.1371/journal.pone.0025807.


Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT.

Bisson JA, Mills B, Paul Helt JC, Zwaka TP, Cohen ED.

Dev Biol. 2015 Feb 1;398(1):80-96. doi: 10.1016/j.ydbio.2014.11.015.


Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells.

Yuzugullu H, Benhaj K, Ozturk N, Senturk S, Celik E, Toylu A, Tasdemir N, Yilmaz M, Erdal E, Akcali KC, Atabey N, Ozturk M.

Mol Cancer. 2009 Oct 22;8:90. doi: 10.1186/1476-4598-8-90.


Aberrant amplification of the crosstalk between canonical Wnt signaling and N-glycosylation gene DPAGT1 promotes oral cancer.

Jamal B, Sengupta PK, Gao ZN, Nita-Lazar M, Amin B, Jalisi S, Bouchie MP, Kukuruzinska MA.

Oral Oncol. 2012 Jun;48(6):523-9. doi: 10.1016/j.oraloncology.2012.01.010.


Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells.

Taki M, Kamata N, Yokoyama K, Fujimoto R, Tsutsumi S, Nagayama M.

Cancer Sci. 2003 Jul;94(7):593-7.


Redundant expression of canonical Wnt ligands in human breast cancer cell lines.

Benhaj K, Akcali KC, Ozturk M.

Oncol Rep. 2006 Mar;15(3):701-7.


Prognostic significance of Ror2 and Wnt5a expression in medulloblastoma.

Lee SE, Lim SD, Kang SY, Suh SB, Suh YL.

Brain Pathol. 2013 Jul;23(4):445-53. doi: 10.1111/bpa.12017.


Wnt5a is associated with cigarette smoke-related lung carcinogenesis via protein kinase C.

Whang YM, Jo U, Sung JS, Ju HJ, Kim HK, Park KH, Lee JW, Koh IS, Kim YH.

PLoS One. 2013;8(1):e53012. doi: 10.1371/journal.pone.0053012.


Migration and invasion of oral squamous carcinoma cells is promoted by WNT5A, a regulator of cancer progression.

Prgomet Z, Axelsson L, Lindberg P, Andersson T.

J Oral Pathol Med. 2015 Nov;44(10):776-84. doi: 10.1111/jop.12292.


WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1.

Vassallo I, Zinn P, Lai M, Rajakannu P, Hamou MF, Hegi ME.

Oncogene. 2016 Jan 7;35(1):12-21. doi: 10.1038/onc.2015.61.


HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer.

Chang HR, Nam S, Kook MC, Kim KT, Liu X, Yao H, Jung HR, Lemos R Jr, Seo HH, Park HS, Gim Y, Hong D, Huh I, Kim YW, Tan D, Liu CG, Powis G, Park T, Liang H, Kim YH.

Gut. 2016 Jan;65(1):19-32. doi: 10.1136/gutjnl-2014-307918.


The Wnt5a/Ror2 noncanonical signaling pathway inhibits canonical Wnt signaling in K562 cells.

Yuan Y, Niu CC, Deng G, Li ZQ, Pan J, Zhao C, Yang ZL, Si WK.

Int J Mol Med. 2011 Jan;27(1):63-9. doi: 10.3892/ijmm.2010.560.


Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis.

Xi S, Xu H, Shan J, Tao Y, Hong JA, Inchauste S, Zhang M, Kunst TF, Mercedes L, Schrump DS.

J Clin Invest. 2013 Mar;123(3):1241-61. doi: 10.1172/JCI61271.


Wnt5a suppresses colon cancer by inhibiting cell proliferation and epithelial-mesenchymal transition.

Cheng R, Sun B, Liu Z, Zhao X, Qi L, Li Y, Gu Q.

J Cell Physiol. 2014 Dec;229(12):1908-17. doi: 10.1002/jcp.24566.


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