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Items: 1 to 20 of 273

1.

The PPARδ agonist GW0742 inhibits neuroinflammation, but does not restore neurogenesis or prevent early delayed hippocampal-dependent cognitive impairment after whole-brain irradiation.

Schnegg CI, Greene-Schloesser D, Kooshki M, Payne VS, Hsu FC, Robbins ME.

Free Radic Biol Med. 2013 Aug;61:1-9. doi: 10.1016/j.freeradbiomed.2013.03.002. Epub 2013 Mar 14.

2.

The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation.

Ramanan S, Kooshki M, Zhao W, Hsu FC, Riddle DR, Robbins ME.

Int J Radiat Oncol Biol Phys. 2009 Nov 1;75(3):870-7. doi: 10.1016/j.ijrobp.2009.06.059.

3.

Selective inhibition of microglia-mediated neuroinflammation mitigates radiation-induced cognitive impairment.

Jenrow KA, Brown SL, Lapanowski K, Naei H, Kolozsvary A, Kim JH.

Radiat Res. 2013 May;179(5):549-56. doi: 10.1667/RR3026.1. Epub 2013 Apr 5.

4.

Kukoamine A Prevents Radiation-Induced Neuroinflammation and Preserves Hippocampal Neurogenesis in Rats by Inhibiting Activation of NF-κB and AP-1.

Zhang Y, Gao L, Cheng Z, Cai J, Niu Y, Meng W, Zhao Q.

Neurotox Res. 2017 Feb;31(2):259-268. doi: 10.1007/s12640-016-9679-4. Epub 2016 Nov 4.

PMID:
27815817
5.

Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation.

Wong-Goodrich SJ, Pfau ML, Flores CT, Fraser JA, Williams CL, Jones LW.

Cancer Res. 2010 Nov 15;70(22):9329-38. doi: 10.1158/0008-5472.CAN-10-1854. Epub 2010 Sep 30.

6.

The peroxisomal proliferator-activated receptor (PPAR) α agonist, fenofibrate, prevents fractionated whole-brain irradiation-induced cognitive impairment.

Greene-Schloesser D, Payne V, Peiffer AM, Hsu FC, Riddle DR, Zhao W, Chan MD, Metheny-Barlow L, Robbins ME.

Radiat Res. 2014 Jan;181(1):33-44. doi: 10.1667/RR13202.1. Epub 2014 Jan 7.

7.

Tamoxifen alleviates irradiation-induced brain injury by attenuating microglial inflammatory response in vitro and in vivo.

Liu JL, Tian DS, Li ZW, Qu WS, Zhan Y, Xie MJ, Yu ZY, Wang W, Wu G.

Brain Res. 2010 Feb 26;1316:101-11. doi: 10.1016/j.brainres.2009.12.055. Epub 2010 Jan 4.

PMID:
20044983
8.

PPARδ agonist GW0742 ameliorates Aβ1-42-induced hippocampal neurotoxicity in mice.

An YQ, Zhang CT, Du Y, Zhang M, Tang SS, Hu M, Long Y, Sun HB, Hong H.

Metab Brain Dis. 2016 Jun;31(3):663-71. doi: 10.1007/s11011-016-9800-7. Epub 2016 Feb 11.

PMID:
26864581
9.

Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment.

Lee TC, Greene-Schloesser D, Payne V, Diz DI, Hsu FC, Kooshki M, Mustafa R, Riddle DR, Zhao W, Chan MD, Robbins ME.

Radiat Res. 2012 Jul;178(1):46-56. Epub 2012 Jun 12.

10.
11.

Minocycline ameliorates cognitive impairment induced by whole-brain irradiation: an animal study.

Zhang L, Li K, Sun R, Zhang Y, Ji J, Huang P, Yang H, Tian Y.

Radiat Oncol. 2014 Dec 12;9:281. doi: 10.1186/s13014-014-0281-8.

12.

Forced running exercise attenuates hippocampal neurogenesis impairment and the neurocognitive deficits induced by whole-brain irradiation via the BDNF-mediated pathway.

Ji JF, Ji SJ, Sun R, Li K, Zhang Y, Zhang LY, Tian Y.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):646-51. doi: 10.1016/j.bbrc.2013.12.031. Epub 2013 Dec 11.

PMID:
24333433
13.

AT1 receptor antagonism does not influence early radiation-induced changes in microglial activation or neurogenesis in the normal rat brain.

Conner KR, Forbes ME, Lee WH, Lee YW, Riddle DR.

Radiat Res. 2011 Jul;176(1):71-83. Epub 2011 May 5.

14.

Relationship between irradiation-induced neuro-inflammatory environments and impaired cognitive function in the developing brain of mice.

Dong X, Luo M, Huang G, Zhang J, Tong F, Cheng Y, Cai Q, Dong J, Wu G, Cheng J.

Int J Radiat Biol. 2015 Mar;91(3):224-39. doi: 10.3109/09553002.2014.988895. Epub 2015 Jan 30.

PMID:
25426696
15.

Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ-ray radiation.

Oh SB, Park HR, Jang YJ, Choi SY, Son TG, Lee J.

Br J Pharmacol. 2013 Jan;168(2):421-31. doi: 10.1111/j.1476-5381.2012.02142.x.

16.

Effects of the AT1 receptor antagonist L-158,809 on microglia and neurogenesis after fractionated whole-brain irradiation.

Conner KR, Payne VS, Forbes ME, Robbins ME, Riddle DR.

Radiat Res. 2010 Jan;173(1):49-61. doi: 10.1667/RR1821.1.

17.

Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus.

Jenrow KA, Brown SL, Liu J, Kolozsvary A, Lapanowski K, Kim JH.

Radiat Oncol. 2010 Feb 1;5:6. doi: 10.1186/1748-717X-5-6.

18.

PPARδ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-κB and inhibition of the PKCα/MEK1/2/ERK1/2/AP-1 pathway.

Schnegg CI, Kooshki M, Hsu FC, Sui G, Robbins ME.

Free Radic Biol Med. 2012 May 1;52(9):1734-43. doi: 10.1016/j.freeradbiomed.2012.02.032. Epub 2012 Mar 3.

19.

Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice.

Rola R, Raber J, Rizk A, Otsuka S, VandenBerg SR, Morhardt DR, Fike JR.

Exp Neurol. 2004 Aug;188(2):316-30.

PMID:
15246832
20.

Irradiation-induced hippocampal neurogenesis impairment is associated with epigenetic regulation of bdnf gene transcription.

Ji S, Tian Y, Lu Y, Sun R, Ji J, Zhang L, Duan S.

Brain Res. 2014 Aug 19;1577:77-88. doi: 10.1016/j.brainres.2014.06.035. Epub 2014 Jul 11.

PMID:
25020123

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