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Items: 1 to 20 of 79

1.

GPCR biased ligands as novel heart failure therapeutics.

Violin JD, Soergel DG, Boerrigter G, Burnett JC Jr, Lark MW.

Trends Cardiovasc Med. 2013 Oct;23(7):242-9. doi: 10.1016/j.tcm.2013.01.002. Review.

PMID:
23499300
2.

Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology.

DeWire SM, Violin JD.

Circ Res. 2011 Jul 8;109(2):205-16. doi: 10.1161/CIRCRESAHA.110.231308. Review.

3.

Biased ligands at G-protein-coupled receptors: promise and progress.

Violin JD, Crombie AL, Soergel DG, Lark MW.

Trends Pharmacol Sci. 2014 Jul;35(7):308-16. doi: 10.1016/j.tips.2014.04.007. Review. Erratum in: Trends Pharmacol Sci. 2014 Sep;35(9):489.

PMID:
24878326
4.

Biased agonism of the angiotensin II type 1 receptor.

Godin CM, Ferguson SS.

Mini Rev Med Chem. 2012 Aug;12(9):812-6. Review.

PMID:
22681254
5.

Biased ligands: pathway validation for novel GPCR therapeutics.

Rominger DH, Cowan CL, Gowen-MacDonald W, Violin JD.

Curr Opin Pharmacol. 2014 Jun;16:108-15. doi: 10.1016/j.coph.2014.04.002. Review.

PMID:
24834870
6.

Refining efficacy: exploiting functional selectivity for drug discovery.

Gesty-Palmer D, Luttrell LM.

Adv Pharmacol. 2011;62:79-107. doi: 10.1016/B978-0-12-385952-5.00009-9. Review.

PMID:
21907907
7.

Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery.

Luttrell LM.

Mol Endocrinol. 2014 Mar;28(3):281-94. doi: 10.1210/me.2013-1314. Review.

8.

Current and future G protein-coupled receptor signaling targets for heart failure therapy.

Siryk-Bathgate A, Dabul S, Lymperopoulos A.

Drug Des Devel Ther. 2013 Oct 11;7:1209-22. doi: 10.2147/DDDT.S35905. Review.

9.

[From bench to bedside: new insights into the treatment of heart failure].

Rengo G, Femminella GD, Liccardo D, de Lucia C, Pirozzi E, Pagano G, Mattiello G, Gargiulo P, Vitagliano A, Cirillo AP, Aruta SF, Allocca E, Leosco D, Perrone-Filardi P.

G Ital Cardiol (Rome). 2012 Apr;13(4):254-62. doi: 10.1714/1056.11557. Review. Italian.

PMID:
22495642
10.

Neuropeptides and neuropeptide receptors: drug targets, and peptide and non-peptide ligands: a tribute to Prof. Dieter Seebach.

Hoyer D, Bartfai T.

Chem Biodivers. 2012 Nov;9(11):2367-87. doi: 10.1002/cbdv.201200288. Review.

PMID:
23161624
11.

Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy.

Rahmeh R, Damian M, Cottet M, Orcel H, Mendre C, Durroux T, Sharma KS, Durand G, Pucci B, Trinquet E, Zwier JM, Deupi X, Bron P, Banères JL, Mouillac B, Granier S.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6733-8. doi: 10.1073/pnas.1201093109.

12.

New strategies in drug discovery for GPCRs: high throughput detection of cellular ERK phosphorylation.

Crouch MF, Osmond RI.

Comb Chem High Throughput Screen. 2008 Jun;11(5):344-56.

PMID:
18537556
13.

G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey.

Kratochwil NA, Gatti-McArthur S, Hoener MC, Lindemann L, Christ AD, Green LG, Guba W, Martin RE, Malherbe P, Porter RH, Slack JP, Winnig M, Dehmlow H, Grether U, Hertel C, Narquizian R, Panousis CG, Kolczewski S, Steward L.

Curr Top Med Chem. 2011;11(15):1902-24.

PMID:
21470172
14.

Allosteric modulation of G protein-coupled receptors.

May LT, Avlani VA, Sexton PM, Christopoulos A.

Curr Pharm Des. 2004;10(17):2003-13. Review.

PMID:
15279541
15.

Regulation of G protein-coupled receptors by allosteric ligands.

Lane JR, Abdul-Ridha A, Canals M.

ACS Chem Neurosci. 2013 Apr 17;4(4):527-34. doi: 10.1021/cn400005t. Review.

16.

Development of a cyclic adenosine monophosphate assay for Gi-coupled G protein-coupled receptors by utilizing the endogenous calcitonin activity in Chinese hamster ovary cells.

Wang Y, Kong Y, Shei GJ, Kang L, Cvijic ME.

Assay Drug Dev Technol. 2011 Oct;9(5):522-31. doi: 10.1089/adt.2010.0361.

PMID:
21561374
17.

Bridging the gap: bitopic ligands of G-protein-coupled receptors.

Lane JR, Sexton PM, Christopoulos A.

Trends Pharmacol Sci. 2013 Jan;34(1):59-66. doi: 10.1016/j.tips.2012.10.003. Review.

PMID:
23177916
18.

Emerging paradigms in GPCR allostery: implications for drug discovery.

Wootten D, Christopoulos A, Sexton PM.

Nat Rev Drug Discov. 2013 Aug;12(8):630-44. doi: 10.1038/nrd4052. Review.

PMID:
23903222
19.

G protein-coupled receptor signaling complexity in neuronal tissue: implications for novel therapeutics.

Maudsley S, Martin B, Luttrell LM.

Curr Alzheimer Res. 2007 Feb;4(1):3-19. Review.

PMID:
17316162
20.

G-protein-coupled receptor-focused drug discovery using a target class platform approach.

Heilker R, Wolff M, Tautermann CS, Bieler M.

Drug Discov Today. 2009 Mar;14(5-6):231-40. doi: 10.1016/j.drudis.2008.11.011. Review.

PMID:
19121411
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