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Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells.

An N, Lin YW, Mahajan S, Kellner JN, Wang Y, Li Z, Kraft AS, Kang Y.

Stem Cells. 2013 Jun;31(6):1202-12. doi: 10.1002/stem.1369.


Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice.

An N, Kraft AS, Kang Y.

J Hematol Oncol. 2013 Jan 29;6:12. doi: 10.1186/1756-8722-6-12.


PIM kinases are essential for chronic lymphocytic leukemia cell survival (PIM2/3) and CXCR4-mediated microenvironmental interactions (PIM1).

Decker S, Finter J, Forde AJ, Kissel S, Schwaller J, Mack TS, Kuhn A, Gray N, Follo M, Jumaa H, Burger M, Zirlik K, Pfeifer D, Miduturu CV, Eibel H, Veelken H, Dierks C.

Mol Cancer Ther. 2014 May;13(5):1231-45. doi: 10.1158/1535-7163.MCT-13-0575-T. Epub 2014 Mar 21.


Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration.

Grundler R, Brault L, Gasser C, Bullock AN, Dechow T, Woetzel S, Pogacic V, Villa A, Ehret S, Berridge G, Spoo A, Dierks C, Biondi A, Knapp S, Duyster J, Schwaller J.

J Exp Med. 2009 Aug 31;206(9):1957-70. doi: 10.1084/jem.20082074. Epub 2009 Aug 17.


The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.

Saurabh K, Scherzer MT, Shah PP, Mims AS, Lockwood WW, Kraft AS, Beverly LJ.

Oncotarget. 2014 Sep 30;5(18):8503-14.


Kit regulates maintenance of quiescent hematopoietic stem cells.

Thorén LA, Liuba K, Bryder D, Nygren JM, Jensen CT, Qian H, Antonchuk J, Jacobsen SE.

J Immunol. 2008 Feb 15;180(4):2045-53.


Bid protects the mouse hematopoietic system following hydroxyurea-induced replicative stress.

Liu Y, Aiello A, Zinkel SS.

Cell Death Differ. 2012 Oct;19(10):1602-12. doi: 10.1038/cdd.2012.38. Epub 2012 Apr 20.


Developmental stage-specific effects of Pim-1 dysregulation on murine bone marrow B cell development.

Xu Z, Gwin KA, Li Y, Medina KL.

BMC Immunol. 2016 Jun 10;17(1):16. doi: 10.1186/s12865-016-0152-1.


Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion.

Lu J, Sun Y, Nombela-Arrieta C, Du KP, Park SY, Chai L, Walkley C, Luo HR, Silberstein LE.

Exp Hematol. 2012 Apr;40(4):307-17.e3. doi: 10.1016/j.exphem.2011.11.010. Epub 2011 Dec 8.


Deficiency of GRP94 in the hematopoietic system alters proliferation regulators in hematopoietic stem cells.

Luo B, Tseng CC, Adams GB, Lee AS.

Stem Cells Dev. 2013 Dec 1;22(23):3062-73. doi: 10.1089/scd.2013.0181. Epub 2013 Aug 20.


Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors.

Mikkers H, Nawijn M, Allen J, Brouwers C, Verhoeven E, Jonkers J, Berns A.

Mol Cell Biol. 2004 Jul;24(13):6104-15.


Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5.

Li G, Wang Z, Miskimen KL, Zhang Y, Tse W, Bunting KD.

PLoS One. 2010 Feb 10;5(2):e9152. doi: 10.1371/journal.pone.0009152.


Aryl hydrocarbon receptor-null allele mice have hematopoietic stem/progenitor cells with abnormal characteristics and functions.

Singh KP, Garrett RW, Casado FL, Gasiewicz TA.

Stem Cells Dev. 2011 May;20(5):769-84. doi: 10.1089/scd.2010.0333. Epub 2010 Nov 9.


Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo.

Haneline LS, White H, Yang FC, Chen S, Orschell C, Kapur R, Ingram DA.

Blood. 2006 Feb 15;107(4):1375-82. Epub 2005 Oct 20.


Evidence that the Pim1 kinase gene is a direct target of HOXA9.

Hu YL, Passegué E, Fong S, Largman C, Lawrence HJ.

Blood. 2007 Jun 1;109(11):4732-8. Epub 2007 Feb 27.


Donor hematopoietic stem cells confer long-term marrow reconstitution by self-renewal divisions exceeding to that of host cells.

Roy S, Javed S, Jain SK, Majumdar SS, Mukhopadhyay A.

PLoS One. 2012;7(12):e50693. doi: 10.1371/journal.pone.0050693. Epub 2012 Dec 5.


Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null mice.

Ito CY, Li CY, Bernstein A, Dick JE, Stanford WL.

Blood. 2003 Jan 15;101(2):517-23. Epub 2002 Aug 29.


Rapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence.

Luo Y, Li L, Zou P, Wang J, Shao L, Zhou D, Liu L.

Transplantation. 2014 Jan 15;97(1):20-9. doi: 10.1097/TP.0b013e3182a7fcf8.


Pim1 kinase regulates c-Kit gene translation.

An N, Cen B, Cai H, Song JH, Kraft A, Kang Y.

Exp Hematol Oncol. 2016 Dec 30;5:31. doi: 10.1186/s40164-016-0060-3. eCollection 2016.


Protective role of connexin 32 in steady-state hematopoiesis, regeneration state, and leukemogenesis.

Hirabayashi Y, Yoon BI, Tsuboi I, Huo Y, Kodama Y, Kanno J, Ott T, Trosko JE, Inoue T.

Exp Biol Med (Maywood). 2007 May;232(5):700-12.


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