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SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway.

Zhang B, Cui S, Bai X, Zhuo L, Sun X, Hong Q, Fu B, Wang J, Chen X, Cai G.

Age (Dordr). 2013 Dec;35(6):2237-53. doi: 10.1007/s11357-013-9520-4. Epub 2013 Mar 14.


SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts.

Huang J, Gan Q, Han L, Li J, Zhang H, Sun Y, Zhang Z, Tong T.

PLoS One. 2008 Mar 5;3(3):e1710. doi: 10.1371/journal.pone.0001710.


High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway.

Mortuza R, Chen S, Feng B, Sen S, Chakrabarti S.

PLoS One. 2013;8(1):e54514. doi: 10.1371/journal.pone.0054514. Epub 2013 Jan 16.


E2F transcription factor 1 regulates cellular and organismal senescence by inhibiting Forkhead box O transcription factors.

Xie Q, Peng S, Tao L, Ruan H, Yang Y, Li TM, Adams U, Meng S, Bi X, Dong MQ, Yuan Z.

J Biol Chem. 2014 Dec 5;289(49):34205-13. doi: 10.1074/jbc.M114.587170. Epub 2014 Oct 24.


Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia.

Rangarajan P, Karthikeyan A, Lu J, Ling EA, Dheen ST.

Neuroscience. 2015 Dec 17;311:398-414. doi: 10.1016/j.neuroscience.2015.10.048. Epub 2015 Oct 30.


Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells.

Diep CH, Charles NJ, Gilks CB, Kalloger SE, Argenta PA, Lange CA.

Cell Cycle. 2013 May 1;12(9):1433-49. doi: 10.4161/cc.24550. Epub 2013 Apr 10.


The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells.

Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D, Brenner DA.

Gastroenterology. 2007 Apr;132(4):1434-46. Epub 2007 Jan 25.


Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblasts.

Kyoung Kim H, Kyoung Kim Y, Song IH, Baek SH, Lee SR, Hye Kim J, Kim JR.

J Gerontol A Biol Sci Med Sci. 2005 Jan;60(1):4-9.


The effect of FoxO1 on the proliferation of rat mesangial cells under high glucose conditions.

Liu F, Ma XJ, Wang QZ, Zhao YY, Wu LN, Qin GJ.

Nephrol Dial Transplant. 2014 Oct;29(10):1879-87. doi: 10.1093/ndt/gfu202. Epub 2014 Jun 8.


Autophagy impairment induces premature senescence in primary human fibroblasts.

Kang HT, Lee KB, Kim SY, Choi HR, Park SC.

PLoS One. 2011;6(8):e23367. doi: 10.1371/journal.pone.0023367. Epub 2011 Aug 8.


Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming.

Diep CH, Knutson TP, Lange CA.

Mol Cancer Res. 2016 Feb;14(2):141-62. doi: 10.1158/1541-7786.MCR-15-0431. Epub 2015 Nov 17.


Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis.

Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, Fang F, Chang Y.

PLoS One. 2010 Jul 22;5(7):e11707. doi: 10.1371/journal.pone.0011707.


Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1.

Arunachalam G, Samuel SM, Marei I, Ding H, Triggle CR.

Br J Pharmacol. 2014 Jan;171(2):523-35. doi: 10.1111/bph.12496.


High glucose downregulates endothelial progenitor cell number via SIRT1.

Balestrieri ML, Rienzo M, Felice F, Rossiello R, Grimaldi V, Milone L, Casamassimi A, Servillo L, Farzati B, Giovane A, Napoli C.

Biochim Biophys Acta. 2008 Jun;1784(6):936-45. doi: 10.1016/j.bbapap.2008.03.004. Epub 2008 Mar 20.


Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1.

Li J, Chen T, Xiao M, Li N, Wang S, Su H, Guo X, Liu H, Yan F, Yang Y, Zhang Y, Bu P.

Oncotarget. 2016 Dec 27;7(52):86648-86659. doi: 10.18632/oncotarget.13429.


Regulation of cellular senescence and p16(INK4a) expression by Id1 and E47 proteins in human diploid fibroblast.

Zheng W, Wang H, Xue L, Zhang Z, Tong T.

J Biol Chem. 2004 Jul 23;279(30):31524-32. Epub 2004 May 11.


Senescence delay and repression of p16INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblasts.

Zhou R, Han L, Li G, Tong T.

Nucleic Acids Res. 2009 Aug;37(15):5183-96. doi: 10.1093/nar/gkp533. Epub 2009 Jun 26.


Effects of glucose restriction on replicative senescence of human diploid fibroblasts IMR-90.

Jin J, Zhang T.

Cell Physiol Biochem. 2013;31(4-5):718-27. doi: 10.1159/000350090. Epub 2013 May 23.

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