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The phenotype of the Cryptococcus-specific CD4+ memory T-cell response is associated with disease severity and outcome in HIV-associated cryptococcal meningitis.

Jarvis JN, Casazza JP, Stone HH, Meintjes G, Lawn SD, Levitz SM, Harrison TS, Koup RA.

J Infect Dis. 2013 Jun 15;207(12):1817-28. doi: 10.1093/infdis/jit099. Epub 2013 Mar 14.


Advancing translational immunology in HIV-associated cryptococcal meningitis.

Williamson PR.

J Infect Dis. 2013 Jun 15;207(12):1793-5. doi: 10.1093/infdis/jit102. Epub 2013 Mar 14. No abstract available.


Cryptococcosis-IRIS is associated with lower cryptococcus-specific IFN-γ responses before antiretroviral therapy but not higher T-cell responses during therapy.

Chang CC, Lim A, Omarjee S, Levitz SM, Gosnell BI, Spelman T, Elliott JH, Carr WH, Moosa MY, Ndung'u T, Lewin SR, French MA.

J Infect Dis. 2013 Sep;208(6):898-906. doi: 10.1093/infdis/jit271. Epub 2013 Jun 12.


CD4+ T Cells Orchestrate Lethal Immune Pathology despite Fungal Clearance during Cryptococcus neoformans Meningoencephalitis.

Neal LM, Xing E, Xu J, Kolbe JL, Osterholzer JJ, Segal BM, Williamson PR, Olszewski MA.

MBio. 2017 Nov 21;8(6). pii: e01415-17. doi: 10.1128/mBio.01415-17.


Immunological profiles of immune restoration disease presenting as mycobacterial lymphadenitis and cryptococcal meningitis.

Tan DB, Yong YK, Tan HY, Kamarulzaman A, Tan LH, Lim A, James I, French M, Price P.

HIV Med. 2008 May;9(5):307-16. doi: 10.1111/j.1468-1293.2008.00565.x.


The CSF Immune Response in HIV-1-Associated Cryptococcal Meningitis: Macrophage Activation, Correlates of Disease Severity, and Effect of Antiretroviral Therapy.

Scriven JE, Graham LM, Schutz C, Scriba TJ, Wilkinson KA, Wilkinson RJ, Boulware DR, Urban BC, Meintjes G, Lalloo DG.

J Acquir Immune Defic Syndr. 2017 Jul 1;75(3):299-307. doi: 10.1097/QAI.0000000000001382.


Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis.

Jarvis JN, Meintjes G, Bicanic T, Buffa V, Hogan L, Mo S, Tomlinson G, Kropf P, Noursadeghi M, Harrison TS.

PLoS Pathog. 2015 Apr 8;11(4):e1004754. doi: 10.1371/journal.ppat.1004754. eCollection 2015 Apr.


IFN-gamma at the site of infection determines rate of clearance of infection in cryptococcal meningitis.

Siddiqui AA, Brouwer AE, Wuthiekanun V, Jaffar S, Shattock R, Irving D, Sheldon J, Chierakul W, Peacock S, Day N, White NJ, Harrison TS.

J Immunol. 2005 Feb 1;174(3):1746-50.


A Glucuronoxylomannan-Associated Immune Signature, Characterized by Monocyte Deactivation and an Increased Interleukin 10 Level, Is a Predictor of Death in Cryptococcal Meningitis.

Scriven JE, Graham LM, Schutz C, Scriba TJ, Wilkinson KA, Wilkinson RJ, Boulware DR, Urban BC, Lalloo DG, Meintjes G.

J Infect Dis. 2016 Jun 1;213(11):1725-34. doi: 10.1093/infdis/jiw007. Epub 2016 Jan 14.


High prevalence of Cryptococcal antigenemia among HIV-infected patients receiving antiretroviral therapy in Ethiopia.

Alemu AS, Kempker RR, Tenna A, Smitson C, Berhe N, Fekade D, Blumberg HM, Aseffa A.

PLoS One. 2013;8(3):e58377. doi: 10.1371/journal.pone.0058377. Epub 2013 Mar 4.


Role of human immunodeficiency virus (HIV)-specific T-cell immunity in control of dual HIV-1 and HIV-2 infection.

Zheng NN, McElrath MJ, Sow PS, Hawes SE, Diallo-Agne H, Stern JE, Li F, Mesher AL, Robinson AD, Gottlieb GS, Huang Y, Kiviat NB.

J Virol. 2007 Sep;81(17):9061-71. Epub 2007 Jun 20.


Very low levels of 25-hydroxyvitamin D are not associated with immunologic changes or clinical outcome in South African patients with HIV-associated cryptococcal meningitis.

Jarvis JN, Bicanic T, Loyse A, Meintjes G, Hogan L, Roberts CH, Shoham S, Perfect JR, Govender NP, Harrison TS.

Clin Infect Dis. 2014 Aug 15;59(4):493-500. doi: 10.1093/cid/ciu349. Epub 2014 May 13.


Relationship of cerebrospinal fluid pressure, fungal burden and outcome in patients with cryptococcal meningitis undergoing serial lumbar punctures.

Bicanic T, Brouwer AE, Meintjes G, Rebe K, Limmathurotsakul D, Chierakul W, Teparrakkul P, Loyse A, White NJ, Wood R, Jaffar S, Harrison T.

AIDS. 2009 Mar 27;23(6):701-6. doi: 10.1097/QAD.0b013e32832605fe.


Cryptococcus neoformans ex vivo capsule size is associated with intracranial pressure and host immune response in HIV-associated cryptococcal meningitis.

Robertson EJ, Najjuka G, Rolfes MA, Akampurira A, Jain N, Anantharanjit J, von Hohenberg M, Tassieri M, Carlsson A, Meya DB, Harrison TS, Fries BC, Boulware DR, Bicanic T.

J Infect Dis. 2014 Jan 1;209(1):74-82. doi: 10.1093/infdis/jit435. Epub 2013 Aug 14.


Interleukin-17 mediated differences in the pathogenesis of HIV-1-associated tuberculous and cryptococcal meningitis.

Marais S, Meintjes G, Lesosky M, Wilkinson KA, Wilkinson RJ.

AIDS. 2016 Jan 28;30(3):395-404. doi: 10.1097/QAD.0000000000000904.


Paradoxical Immune Responses in Non-HIV Cryptococcal Meningitis.

Panackal AA, Wuest SC, Lin YC, Wu T, Zhang N, Kosa P, Komori M, Blake A, Browne SK, Rosen LB, Hagen F, Meis J, Levitz SM, Quezado M, Hammoud D, Bennett JE, Bielekova B, Williamson PR.

PLoS Pathog. 2015 May 28;11(5):e1004884. doi: 10.1371/journal.ppat.1004884. eCollection 2015 May.


Two patients with cryptococcal meningitis and idiopathic CD4 lymphopenia: defective cytokine production and reversal by recombinant interferon- gamma therapy.

Netea MG, Brouwer AE, Hoogendoorn EH, Van der Meer JW, Koolen M, Verweij PE, Kullberg BJ.

Clin Infect Dis. 2004 Nov 1;39(9):e83-7. Epub 2004 Oct 5.


Baseline correlation and comparative kinetics of cerebrospinal fluid colony-forming unit counts and antigen titers in cryptococcal meningitis.

Brouwer AE, Teparrukkul P, Pinpraphaporn S, Larsen RA, Chierakul W, Peacock S, Day N, White NJ, Harrison TS.

J Infect Dis. 2005 Aug 15;192(4):681-4. Epub 2005 Jul 7.


Single-cell level response of HIV-specific and cytomegalovirus-specific CD4 T cells correlate with viral control in chronic HIV-1 subtype A infection.

Eller MA, Eller LA, Ratto-Kim S, Ouma BJ, Lo V, de Souza M, Guwatudde D, Nails B, Michael NL, Wabwire-Mangen F, Robb ML, Marovich MA, Sandberg JK, Currier JR.

J Acquir Immune Defic Syndr. 2012 Sep 1;61(1):9-18. doi: 10.1097/QAI.0b013e31825c1217.


A cryptic cause of cryptococcal meningitis.

Cheung MC, Rachlis AR, Shumak SL.

CMAJ. 2003 Feb 18;168(4):451-2.

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