Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 111

1.

Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition.

Biswas S, Carta F, Scozzafava A, McKenna R, Supuran CT.

Bioorg Med Chem. 2013 Apr 15;21(8):2314-2318. doi: 10.1016/j.bmc.2013.02.022. Epub 2013 Feb 21.

PMID:
23490152
2.

Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols.

Almajan GL, Innocenti A, Puccetti L, Manole G, Barbuceanu S, Saramet I, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52.

PMID:
15837323
3.

Design, synthesis, and docking studies of new 1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase inhibitory activity.

Abdel-Hamid MK, Abdel-Hafez AA, El-Koussi NA, Mahfouz NM, Innocenti A, Supuran CT.

Bioorg Med Chem. 2007 Nov 15;15(22):6975-84. Epub 2007 Aug 22.

PMID:
17822907
4.

Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111.

Lomelino CL, Mahon BP, McKenna R, Carta F, Supuran CT.

Bioorg Med Chem. 2016 Mar 1;24(5):976-81. doi: 10.1016/j.bmc.2016.01.019. Epub 2016 Jan 11.

PMID:
26810836
5.

Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.

Temperini C, Cecchi A, Boyle NA, Scozzafava A, Cabeza JE, Wentworth P Jr, Blackburn GM, Supuran CT.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):999-1005. Epub 2007 Dec 15.

PMID:
18162396
6.

Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity.

Congiu C, Onnis V, Deplano A, Balboni G, Dedeoglu N, Supuran CT.

Bioorg Med Chem Lett. 2015 Sep 15;25(18):3850-3. doi: 10.1016/j.bmcl.2015.07.060. Epub 2015 Jul 26.

PMID:
26233435
7.

5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies.

Leitans J, Sprudza A, Tanc M, Vozny I, Zalubovskis R, Tars K, Supuran CT.

Bioorg Med Chem. 2013 Sep 1;21(17):5130-8. doi: 10.1016/j.bmc.2013.06.041. Epub 2013 Jun 27.

PMID:
23859774
8.

Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.

Ozensoy O, Puccetti L, Fasolis G, Arslan O, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.

PMID:
16168653
9.

Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.

Carta F, Garaj V, Maresca A, Wagner J, Avvaru BS, Robbins AH, Scozzafava A, McKenna R, Supuran CT.

Bioorg Med Chem. 2011 May 15;19(10):3105-19. doi: 10.1016/j.bmc.2011.04.005. Epub 2011 Apr 6.

PMID:
21515057
10.

Structural study of the location of the phenyl tail of benzene sulfonamides and the effect on human carbonic anhydrase inhibition.

Güzel-Akdemir O, Biswas S, Lastra K, McKenna R, Supuran CT.

Bioorg Med Chem. 2013 Nov 1;21(21):6674-80. doi: 10.1016/j.bmc.2013.08.011. Epub 2013 Aug 12.

PMID:
24012377
11.

Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations.

Wagner J, Avvaru BS, Robbins AH, Scozzafava A, Supuran CT, McKenna R.

Bioorg Med Chem. 2010 Jul 15;18(14):4873-8. doi: 10.1016/j.bmc.2010.06.028. Epub 2010 Jun 15.

12.

New series of sulfonamides containing amino acid moiety act as effective and selective inhibitors of tumor-associated carbonic anhydrase XII.

Ceruso M, Bragagni M, AlOthman Z, Osman SM, Supuran CT.

J Enzyme Inhib Med Chem. 2015 Jun;30(3):430-4. doi: 10.3109/14756366.2014.942659. Epub 2014 Aug 4.

PMID:
25089707
14.

Synthesis of a new series of N⁴-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.

Sławiński J, Brzozowski Z, Żołnowska B, Szafrański K, Pogorzelska A, Vullo D, Supuran CT.

Eur J Med Chem. 2014 Sep 12;84:59-67. doi: 10.1016/j.ejmech.2014.06.074. Epub 2014 Jul 5.

PMID:
25016228
15.

Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.

Biswas S, Aggarwal M, Güzel Ö, Scozzafava A, McKenna R, Supuran CT.

Bioorg Med Chem. 2011 Jun 15;19(12):3732-8. doi: 10.1016/j.bmc.2011.05.006. Epub 2011 May 10.

PMID:
21620713
16.

Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.

Avvaru BS, Wagner JM, Maresca A, Scozzafava A, Robbins AH, Supuran CT, McKenna R.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81. doi: 10.1016/j.bmcl.2010.06.082. Epub 2010 Jun 17.

PMID:
20605094
17.

Inhibition of human carbonic anhydrase isozymes I, II, IX and XII with a new series of sulfonamides incorporating aroylhydrazone-, [1,2,4]triazolo[3,4-b][1,3,4]thiadiazinyl- or 2-(cyanophenylmethylene)-1,3,4-thiadiazol-3(2H)-yl moieties.

Alafeefy AM, Abdel-Aziz HA, Vullo D, Al-Tamimi AM, Awaad AS, Mohamed MA, Capasso C, Supuran CT.

J Enzyme Inhib Med Chem. 2015 Feb;30(1):52-6. doi: 10.3109/14756366.2013.877897. Epub 2014 Mar 25.

PMID:
24666294
18.

Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties, diuretic, and anticonvulsant action.

Diaz JR, Camí GE, Liu-González M, Vega DR, Vullo D, Juárez A, Pedregosa JC, Supuran CT.

J Enzyme Inhib Med Chem. 2016 Dec;31(6):1102-10. doi: 10.3109/14756366.2015.1096270. Epub 2015 Oct 26.

PMID:
26497704
19.

Amide derivatives with pyrazole carboxylic acids of 5-amino-1,3,4-thiadiazole 2-sulfonamide as new carbonic anhydrase inhibitors: synthesis and investigation of inhibitory effects.

Bülbül M, Kasimoğullari R, Küfrevioğlu OI.

J Enzyme Inhib Med Chem. 2008 Dec;23(6):895-900. doi: 10.1080/14756360701626173 .

PMID:
18618324
20.

Carbonic anhydrase inhibitors. Synthesis of topically effective intraocular pressure lowering agents derived from 5-(omega-aminoalkylcarboxamido)-1,3,4-thiadiazole-2-sulfonamide.

Barboiu M, Supuran CT, Menabuoni L, Scozzafava A, Mincione F, Briganti F, Mincione G.

J Enzyme Inhib. 2000;15(1):23-46.

PMID:
10850953

Supplemental Content

Support Center