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Items: 1 to 20 of 84

1.

Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.

Bin NR, Jung CH, Piggott C, Sugita S.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4610-5. doi: 10.1073/pnas.1214887110.

2.

Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis.

Bin NR, Jung CH, Kim B, Chandrasegram P, Turlova E, Zhu D, Gaisano HY, Sun HS, Sugita S.

J Cell Sci. 2015 May 15;128(10):1946-60. doi: 10.1242/jcs.165662.

3.

Domain 3a of Munc18-1 plays a crucial role at the priming stage of exocytosis.

Han GA, Bin NR, Kang SY, Han L, Sugita S.

J Cell Sci. 2013 Jun 1;126(Pt 11):2361-71. doi: 10.1242/jcs.126862.

4.

Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells.

Han L, Jiang T, Han GA, Malintan NT, Xie L, Wang L, Tse FW, Gaisano HY, Collins BM, Meunier FA, Sugita S.

Mol Biol Cell. 2009 Dec;20(23):4962-75. doi: 10.1091/mbc.E09-08-0712.

5.

Hemophagocytic lymphohistiocytosis caused by dominant-negative mutations in STXBP2 that inhibit SNARE-mediated membrane fusion.

Spessott WA, Sanmillan ML, McCormick ME, Patel N, Villanueva J, Zhang K, Nichols KE, Giraudo CG.

Blood. 2015 Mar 5;125(10):1566-77. doi: 10.1182/blood-2014-11-610816.

6.

Munc18-2 regulates exocytotic membrane fusion positively interacting with syntaxin-3 in RBL-2H3 cells.

Tadokoro S, Kurimoto T, Nakanishi M, Hirashima N.

Mol Immunol. 2007 Jul;44(13):3427-33.

PMID:
17408745
7.

Munc18-2 and syntaxin 3 control distinct essential steps in mast cell degranulation.

Brochetta C, Suzuki R, Vita F, Soranzo MR, Claver J, Madjene LC, Attout T, Vitte J, Varin-Blank N, Zabucchi G, Rivera J, Blank U.

J Immunol. 2014 Jan 1;192(1):41-51. doi: 10.4049/jimmunol.1301277.

8.

Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11.

zur Stadt U, Rohr J, Seifert W, Koch F, Grieve S, Pagel J, Strauss J, Kasper B, Nürnberg G, Becker C, Maul-Pavicic A, Beutel K, Janka G, Griffiths G, Ehl S, Hennies HC.

Am J Hum Genet. 2009 Oct;85(4):482-92. doi: 10.1016/j.ajhg.2009.09.005.

9.

Abrogating Munc18-1-SNARE complex interaction has limited impact on exocytosis in PC12 cells.

Malintan NT, Nguyen TH, Han L, Latham CF, Osborne SL, Wen PJ, Lim SJ, Sugita S, Collins BM, Meunier FA.

J Biol Chem. 2009 Aug 7;284(32):21637-46. doi: 10.1074/jbc.M109.013508.

10.

Munc18-2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T-Lymphocytes.

Dieckmann NM, Hackmann Y, Aricò M, Griffiths GM.

Traffic. 2015 Dec;16(12):1330-41. doi: 10.1111/tra.12337.

11.

Phosphorylation of syntaxin-3 at Thr 14 negatively regulates exocytosis in RBL-2H3 mast cells.

Tadokoro S, Shibata T, Inoh Y, Amano T, Nakanishi M, Hirashima N, Utsunomiya-Tate N.

Cell Biol Int. 2016 May;40(5):589-96. doi: 10.1002/cbin.10600.

PMID:
26936588
12.

Syntaxin binding mechanism and disease-causing mutations in Munc18-2.

Hackmann Y, Graham SC, Ehl S, Höning S, Lehmberg K, Aricò M, Owen DJ, Griffiths GM.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4482-91. doi: 10.1073/pnas.1313474110.

13.

Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis.

Martin-Verdeaux S, Pombo I, Iannascoli B, Roa M, Varin-Blank N, Rivera J, Blank U.

J Cell Sci. 2003 Jan 15;116(Pt 2):325-34.

14.

A pivotal role for pro-335 in balancing the dual functions of Munc18-1 domain-3a in regulated exocytosis.

Han GA, Park S, Bin NR, Jung CH, Kim B, Chandrasegaram P, Matsuda M, Riadi I, Han L, Sugita S.

J Biol Chem. 2014 Nov 28;289(48):33617-28. doi: 10.1074/jbc.M114.584805.

15.
16.

Conformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegans.

Park S, Bin NR, Michael Rajah M, Kim B, Chou TC, Kang SY, Sugita K, Parsaud L, Smith M, Monnier PP, Ikura M, Zhen M, Sugita S.

Mol Biol Cell. 2016 Feb 15;27(4):669-85. doi: 10.1091/mbc.E15-09-0638.

17.

Vesicle fusion probability is determined by the specific interactions of munc18.

Smyth AM, Rickman C, Duncan RR.

J Biol Chem. 2010 Dec 3;285(49):38141-8. doi: 10.1074/jbc.M110.164038.

18.

Slp4-a/granuphilin-a interacts with syntaxin-2/3 in a Munc18-2-dependent manner.

Fukuda M, Imai A, Nashida T, Shimomura H.

J Biol Chem. 2005 Nov 25;280(47):39175-84.

19.

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells.

Côte M, Ménager MM, Burgess A, Mahlaoui N, Picard C, Schaffner C, Al-Manjomi F, Al-Harbi M, Alangari A, Le Deist F, Gennery AR, Prince N, Cariou A, Nitschke P, Blank U, El-Ghazali G, Ménasché G, Latour S, Fischer A, de Saint Basile G.

J Clin Invest. 2009 Dec;119(12):3765-73. doi: 10.1172/JCI40732.

20.

Intrinsic defects in erythroid cells from familial hemophagocytic lymphohistiocytosis type 5 patients identify a role for STXBP2/Munc18-2 in erythropoiesis and phospholipid scrambling.

Kostova EB, Beuger BM, Veldthuis M, van der Werff Ten Bosch J, Kühnle I, van den Akker E, van den Berg TK, van Zwieten R, van Bruggen R.

Exp Hematol. 2015 Dec;43(12):1072-1076.e2. doi: 10.1016/j.exphem.2015.08.007.

PMID:
26320718

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