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Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial.

Davtyan H, Ghochikyan A, Petrushina I, Hovakimyan A, Davtyan A, Poghosyan A, Marleau AM, Movsesyan N, Kiyatkin A, Rasool S, Larsen AK, Madsen PJ, Wegener KM, Ditlevsen DK, Cribbs DH, Pedersen LO, Agadjanyan MG.

J Neurosci. 2013 Mar 13;33(11):4923-34. doi: 10.1523/JNEUROSCI.4672-12.2013.


Low concentrations of anti-Aβ antibodies generated in Tg2576 mice by DNA epitope vaccine fused with 3C3d molecular adjuvant do not affect AD pathology.

Movsesyan N, Davtyan H, Mkrtichyan M, Petrushina I, Tiraturyan T, Ross T, Agadjanyan MG, Ghochikyan A, Cribbs DH.

Hum Gene Ther. 2010 Nov;21(11):1569-76. doi: 10.1089/hum.2009.219.


Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice.

Petrushina I, Ghochikyan A, Mkrtichyan M, Mamikonyan G, Movsesyan N, Ajdari R, Vasilevko V, Karapetyan A, Lees A, Agadjanyan MG, Cribbs DH.

J Neuroinflammation. 2008 Sep 29;5:42. doi: 10.1186/1742-2094-5-42.


MER5101, a novel Aβ1-15:DT conjugate vaccine, generates a robust anti-Aβ antibody response and attenuates Aβ pathology and cognitive deficits in APPswe/PS1ΔE9 transgenic mice.

Liu B, Frost JL, Sun J, Fu H, Grimes S, Blackburn P, Lemere CA.

J Neurosci. 2013 Apr 17;33(16):7027-37. doi: 10.1523/JNEUROSCI.5924-12.2013.


Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice.

Petrushina I, Ghochikyan A, Mktrichyan M, Mamikonyan G, Movsesyan N, Davtyan H, Patel A, Head E, Cribbs DH, Agadjanyan MG.

J Neurosci. 2007 Nov 14;27(46):12721-31.


Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide.

Agadjanyan MG, Ghochikyan A, Petrushina I, Vasilevko V, Movsesyan N, Mkrtichyan M, Saing T, Cribbs DH.

J Immunol. 2005 Feb 1;174(3):1580-6.


Vaccination of Alzheimer's model mice with adenovirus vector containing quadrivalent foldable Abeta(1-15) reduces Abeta burden and behavioral impairment without Abeta-specific T cell response.

Zou J, Yao Z, Zhang G, Wang H, Xu J, Yew DT, Forster EL.

J Neurol Sci. 2008 Sep 15;272(1-2):87-98. doi: 10.1016/j.jns.2008.05.003.


HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses.

Bowers WJ, Mastrangelo MA, Stanley HA, Casey AE, Milo LJ Jr, Federoff HJ.

Neurobiol Aging. 2005 Apr;26(4):393-407. Erratum in: Neurobiol Aging. 2005 Apr;26(4):391.


CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation.

Obregon D, Hou H, Bai Y, Nikolic WV, Mori T, Luo D, Zeng J, Ehrhart J, Fernandez F, Morgan D, Giunta B, Town T, Tan J.

Neurobiol Dis. 2008 Feb;29(2):336-53.


An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.

Adolfsson O, Pihlgren M, Toni N, Varisco Y, Buccarello AL, Antoniello K, Lohmann S, Piorkowska K, Gafner V, Atwal JK, Maloney J, Chen M, Gogineni A, Weimer RM, Mortensen DL, Friesenhahn M, Ho C, Paul R, Pfeifer A, Muhs A, Watts RJ.

J Neurosci. 2012 Jul 11;32(28):9677-89. doi: 10.1523/JNEUROSCI.4742-11.2012.


Strikingly reduced amyloid burden and improved behavioral performance in Alzheimer's disease mice immunized with recombinant chimeric vaccines by hexavalent foldable Aβ₁₋₁₅ fused to toxin-derived carrier proteins.

Yu YZ, Wang WB, Chen A, Chang Q, Liu S, Zhao M, Wang S, Qiu WY, Pang XB, Xu Q, Sun ZW.

J Alzheimers Dis. 2014;41(1):243-60. doi: 10.3233/JAD-132177.


Nonhuman amyloid oligomer epitope reduces Alzheimer's-like neuropathology in 3xTg-AD transgenic mice.

Rasool S, Martinez-Coria H, Milton S, Glabe CG.

Mol Neurobiol. 2013 Dec;48(3):931-40. doi: 10.1007/s12035-013-8478-7.


The Peptide Vaccine Combined with Prior Immunization of a Conventional Diphtheria-Tetanus Toxoid Vaccine Induced Amyloid β Binding Antibodies on Cynomolgus Monkeys and Guinea Pigs.

Yano A, Ito K, Miwa Y, Kanazawa Y, Chiba A, Iigo Y, Kashimoto Y, Kanda A, Murata S, Makino M.

J Immunol Res. 2015;2015:786501. doi: 10.1155/2015/786501.


Vaccine-induced Aβ-specific CD8+ T cells do not trigger autoimmune neuroinflammation in a murine model of Alzheimer's disease.

Rosset MB, Lui G, Dansokho C, Chaigneau T, Dorothée G.

J Neuroinflammation. 2015 May 16;12:95. doi: 10.1186/s12974-015-0317-5.


Vaccine efficacy of transcutaneous immunization with amyloid β using a dissolving microneedle array in a mouse model of Alzheimer's disease.

Matsuo K, Okamoto H, Kawai Y, Quan YS, Kamiyama F, Hirobe S, Okada N, Nakagawa S.

J Neuroimmunol. 2014 Jan 15;266(1-2):1-11. doi: 10.1016/j.jneuroim.2013.11.002.


Co-immunization with DNA and protein mixture: a safe and efficacious immunotherapeutic strategy for Alzheimer's disease in PDAPP mice.

Liu S, Shi D, Wang HC, Yu YZ, Xu Q, Sun ZW.

Sci Rep. 2015 Jan 14;5:7771. doi: 10.1038/srep07771.


Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific.

Zago W, Buttini M, Comery TA, Nishioka C, Gardai SJ, Seubert P, Games D, Bard F, Schenk D, Kinney GG.

J Neurosci. 2012 Feb 22;32(8):2696-702. doi: 10.1523/JNEUROSCI.1676-11.2012.


Active Aβ vaccination fails to enhance amyloid clearance in a mouse model of Alzheimer's disease with Aβ42-driven pathology.

Nemirovsky A, Shapiro J, Baron R, Kompaniets A, Monsonego A.

J Neuroimmunol. 2012 Jun 15;247(1-2):95-9. doi: 10.1016/j.jneuroim.2012.03.017.


The MultiTEP platform-based Alzheimer's disease epitope vaccine activates a broad repertoire of T helper cells in nonhuman primates.

Davtyan H, Ghochikyan A, Petrushina I, Hovakimyan A, Davtyan A, Cribbs DH, Agadjanyan MG.

Alzheimers Dement. 2014 May;10(3):271-83. doi: 10.1016/j.jalz.2013.12.003.

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