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Items: 1 to 20 of 174


A unified mixed-effects model for rare-variant association in sequencing studies.

Sun J, Zheng Y, Hsu L.

Genet Epidemiol. 2013 May;37(4):334-44. doi: 10.1002/gepi.21717. Epub 2013 Mar 9.


Reconsidering association testing methods using single-variant test statistics as alternatives to pooling tests for sequence data with rare variants.

Kinnamon DD, Hershberger RE, Martin ER.

PLoS One. 2012;7(2):e30238. doi: 10.1371/journal.pone.0030238. Epub 2012 Feb 17.


Optimal tests for rare variant effects in sequencing association studies.

Lee S, Wu MC, Lin X.

Biostatistics. 2012 Sep;13(4):762-75. doi: 10.1093/biostatistics/kxs014. Epub 2012 Jun 14.


Rare variant association testing for next-generation sequencing data via hierarchical clustering.

Tachmazidou I, Morris A, Zeggini E.

Hum Hered. 2012;74(3-4):165-71. doi: 10.1159/000346022. Epub 2013 Apr 11.


Sequence kernel association tests for the combined effect of rare and common variants.

Ionita-Laza I, Lee S, Makarov V, Buxbaum JD, Lin X.

Am J Hum Genet. 2013 Jun 6;92(6):841-53. doi: 10.1016/j.ajhg.2013.04.015. Epub 2013 May 16.


A variational Bayes discrete mixture test for rare variant association.

Logsdon BA, Dai JY, Auer PL, Johnsen JM, Ganesh SK, Smith NL, Wilson JG, Tracy RP, Lange LA, Jiao S, Rich SS, Lettre G, Carlson CS, Jackson RD, O'Donnell CJ, Wurfel MM, Nickerson DA, Tang H, Reiner AP, Kooperberg C; NHLBI GO Exome Sequencing Project.

Genet Epidemiol. 2014 Jan;38(1):21-30.


Detecting rare variant effects using extreme phenotype sampling in sequencing association studies.

Barnett IJ, Lee S, Lin X.

Genet Epidemiol. 2013 Feb;37(2):142-51. doi: 10.1002/gepi.21699. Epub 2012 Nov 26.


Efficient unified rare variant association test by modeling the population genetic distribution in case-control studies.

Li H, Chen J.

Genet Epidemiol. 2016 Nov;40(7):579-590. doi: 10.1002/gepi.21995. Epub 2016 Aug 22.


A powerful association test of multiple genetic variants using a random-effects model.

Cheng KF, Lee JY, Zheng W, Li C.

Stat Med. 2014 May 20;33(11):1816-27. doi: 10.1002/sim.6068. Epub 2013 Dec 16.


Robust and Powerful Affected Sibpair Test for Rare Variant Association.

Lin KH, Zöllner S.

Genet Epidemiol. 2015 Jul;39(5):325-33. doi: 10.1002/gepi.21903. Epub 2015 May 13.


Two adaptive weighting methods to test for rare variant associations in family-based designs.

Fang S, Sha Q, Zhang S.

Genet Epidemiol. 2012 Jul;36(5):499-507. doi: 10.1002/gepi.21646. Epub 2012 Jun 1.


A Comparison Study of Fixed and Mixed Effect Models for Gene Level Association Studies of Complex Traits.

Fan R, Chiu CY, Jung J, Weeks DE, Wilson AF, Bailey-Wilson JE, Amos CI, Chen Z, Mills JL, Xiong M.

Genet Epidemiol. 2016 Dec;40(8):702-721. doi: 10.1002/gepi.21984. Epub 2016 Jul 4.


Rare variant association testing by adaptive combination of P-values.

Lin WY, Lou XY, Gao G, Liu N.

PLoS One. 2014 Jan 15;9(1):e85728. doi: 10.1371/journal.pone.0085728. eCollection 2014.


Pathway-based approaches for sequencing-based genome-wide association studies.

Wu G, Zhi D.

Genet Epidemiol. 2013 Jul;37(5):478-94. doi: 10.1002/gepi.21728. Epub 2013 May 5.


gsSKAT: Rapid gene set analysis and multiple testing correction for rare-variant association studies using weighted linear kernels.

Larson NB, McDonnell S, Cannon Albright L, Teerlink C, Stanford J, Ostrander EA, Isaacs WB, Xu J, Cooney KA, Lange E, Schleutker J, Carpten JD, Powell I, Bailey-Wilson JE, Cussenot O, Cancel-Tassin G, Giles GG, MacInnis RJ, Maier C, Whittemore AS, Hsieh CL, Wiklund F, Catolona WJ, Foulkes W, Mandal D, Eeles R, Kote-Jarai Z, Ackerman MJ, Olson TM, Klein CJ, Thibodeau SN, Schaid DJ.

Genet Epidemiol. 2017 May;41(4):297-308. doi: 10.1002/gepi.22036. Epub 2017 Feb 16.


A fast and noise-resilient approach to detect rare-variant associations with deep sequencing data for complex disorders.

Cheung YH, Wang G, Leal SM, Wang S.

Genet Epidemiol. 2012 Nov;36(7):675-85. doi: 10.1002/gepi.21662. Epub 2012 Aug 3.


Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies.

Lee S, Emond MJ, Bamshad MJ, Barnes KC, Rieder MJ, Nickerson DA; NHLBI GO Exome Sequencing Project—ESP Lung Project Team, Christiani DC, Wurfel MM, Lin X.

Am J Hum Genet. 2012 Aug 10;91(2):224-37. doi: 10.1016/j.ajhg.2012.06.007. Epub 2012 Aug 2.


Meta-analysis of Complex Diseases at Gene Level with Generalized Functional Linear Models.

Fan R, Wang Y, Chiu CY, Chen W, Ren H, Li Y, Boehnke M, Amos CI, Moore JH, Xiong M.

Genetics. 2016 Feb;202(2):457-70. doi: 10.1534/genetics.115.180869. Epub 2015 Dec 29.


General framework for meta-analysis of rare variants in sequencing association studies.

Lee S, Teslovich TM, Boehnke M, Lin X.

Am J Hum Genet. 2013 Jul 11;93(1):42-53. doi: 10.1016/j.ajhg.2013.05.010. Epub 2013 Jun 13.


Rare-variant association testing for sequencing data with the sequence kernel association test.

Wu MC, Lee S, Cai T, Li Y, Boehnke M, Lin X.

Am J Hum Genet. 2011 Jul 15;89(1):82-93. doi: 10.1016/j.ajhg.2011.05.029. Epub 2011 Jul 7.

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