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Signaling by p38 MAPK stimulates nuclear localization of the microprocessor component p68 for processing of selected primary microRNAs.

Hong S, Noh H, Chen H, Padia R, Pan ZK, Su SB, Jing Q, Ding HF, Huang S.

Sci Signal. 2013 Mar 12;6(266):ra16. doi: 10.1126/scisignal.2003706.


Distinct cellular functions of MK2.

Kotlyarov A, Yannoni Y, Fritz S, Laass K, Telliez JB, Pitman D, Lin LL, Gaestel M.

Mol Cell Biol. 2002 Jul;22(13):4827-35.


MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia.

Gorog DA, Jabr RI, Tanno M, Sarafraz N, Clark JE, Fisher SG, Cao XB, Bellahcene M, Dighe K, Kabir AM, Quinlan RA, Kato K, Gaestel M, Marber MS, Heads RJ.

Cell Stress Chaperones. 2009 Sep;14(5):477-89. doi: 10.1007/s12192-009-0101-5. Epub 2009 Feb 13.


Cytokine regulation by MAPK activated kinase 2 in keratinocytes exposed to sulfur mustard.

Yego EC, Dillman JF 3rd.

Toxicol In Vitro. 2013 Oct;27(7):2067-75. doi: 10.1016/j.tiv.2013.07.002. Epub 2013 Jul 10.


p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins.

Menon MB, Schwermann J, Singh AK, Franz-Wachtel M, Pabst O, Seidler U, Omary MB, Kotlyarov A, Gaestel M.

J Biol Chem. 2010 Oct 22;285(43):33242-51. doi: 10.1074/jbc.M110.132357. Epub 2010 Aug 19.


The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage.

Tu CC, Zhong Y, Nguyen L, Tsai A, Sridevi P, Tarn WY, Wang JY.

Sci Signal. 2015 Jun 30;8(383):ra64. doi: 10.1126/scisignal.aaa4468.


Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production.

Menon MB, Tiedje C, Lafera J, Ronkina N, Konen T, Kotlyarov A, Gaestel M.

Biochem J. 2013 Dec 1;456(2):163-72. doi: 10.1042/BJ20130755. Erratum in: Biochem J. 2014 Jan 1;457(1):229.


The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis.

Soukup K, Halfmann A, Le Bras M, Sahin E, Vittori S, Poyer F, Schuh C, Luger R, Niederreiter B, Haider T, Stoiber D, Blüml S, Schabbauer G, Kotlyarov A, Gaestel M, Felzmann T, Dohnal AM.

J Immunol. 2015 Jul 15;195(2):541-52. doi: 10.4049/jimmunol.1401663. Epub 2015 Jun 15.


Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2.

Ehlting C, Böhmer O, Hahnel MJ, Thomas M, Zanger UM, Gaestel M, Knoefel WT, Schulte Am Esch J, Häussinger D, Bode JG.

Cell Signal. 2015 Mar;27(3):555-67. doi: 10.1016/j.cellsig.2014.12.016. Epub 2015 Jan 3.


DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.

Reinhardt HC, Hasskamp P, Schmedding I, Morandell S, van Vugt MA, Wang X, Linding R, Ong SE, Weaver D, Carr SA, Yaffe MB.

Mol Cell. 2010 Oct 8;40(1):34-49. doi: 10.1016/j.molcel.2010.09.018.


A novel function for the DEAD-box RNA helicase DDX-23 in primary microRNA processing in Caenorhabditis elegans.

Chu YD, Chen HK, Huang T, Chan SP.

Dev Biol. 2016 Jan 15;409(2):459-72. doi: 10.1016/j.ydbio.2015.11.011. Epub 2015 Nov 18.


SMAD proteins control DROSHA-mediated microRNA maturation.

Davis BN, Hilyard AC, Lagna G, Hata A.

Nature. 2008 Jul 3;454(7200):56-61. doi: 10.1038/nature07086. Epub 2008 Jun 11.


Mitogen-activated protein kinase-activated protein kinase 2 (MK2) in skeletal muscle atrophy and hypertrophy.

Norrby M, Tågerud S.

J Cell Physiol. 2010 Apr;223(1):194-201. doi: 10.1002/jcp.22023.


Post-transcriptional regulation of TNF-induced expression of ICAM-1 and IL-8 in human lung microvascular endothelial cells: an obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27.

Su X, Ao L, Zou N, Song Y, Yang X, Cai GY, Fullerton DA, Meng X.

Biochim Biophys Acta. 2008 Sep;1783(9):1623-31. doi: 10.1016/j.bbamcr.2008.04.009. Epub 2008 Apr 30.


MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.

Streicher JM, Ren S, Herschman H, Wang Y.

Circ Res. 2010 Apr 30;106(8):1434-43. doi: 10.1161/CIRCRESAHA.109.213199. Epub 2010 Mar 25.


p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex.

Tiedje C, Lubas M, Tehrani M, Menon MB, Ronkina N, Rousseau S, Cohen P, Kotlyarov A, Gaestel M.

RNA. 2015 Feb;21(2):262-78. doi: 10.1261/rna.048090.114. Epub 2014 Dec 18.


Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus.

Suomalainen M, Nakano MY, Boucke K, Keller S, Greber UF.

EMBO J. 2001 Mar 15;20(6):1310-9.

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