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β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets.

Xie Y, Grandi E, Puglisi JL, Sato D, Bers DM.

J Mol Cell Cardiol. 2013 May;58:153-61. doi: 10.1016/j.yjmcc.2013.02.009. Epub 2013 Feb 26.


Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle.

Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD.

Circ Arrhythm Electrophysiol. 2014 Dec;7(6):1205-13. doi: 10.1161/CIRCEP.113.001666. Epub 2014 Sep 18.


Reactive oxygen species contribute to the development of arrhythmogenic Ca²⁺ waves during β-adrenergic receptor stimulation in rabbit cardiomyocytes.

Bovo E, Lipsius SL, Zima AV.

J Physiol. 2012 Jul 15;590(14):3291-304. doi: 10.1113/jphysiol.2012.230748. Epub 2012 May 14.


Phospholemman-mediated activation of Na/K-ATPase limits [Na]i and inotropic state during beta-adrenergic stimulation in mouse ventricular myocytes.

Despa S, Tucker AL, Bers DM.

Circulation. 2008 Apr 8;117(14):1849-55. doi: 10.1161/CIRCULATIONAHA.107.754051. Epub 2008 Mar 24.


Contributions of ion channel currents to ventricular action potential changes and induction of early afterdepolarizations during acute hypoxia.

Gaur N, Rudy Y, Hool L.

Circ Res. 2009 Dec 4;105(12):1196-203. doi: 10.1161/CIRCRESAHA.109.202267. Epub 2009 Oct 29.


Dynamical mechanisms of phase-2 early afterdepolarizations in human ventricular myocytes: insights from bifurcation analyses of two mathematical models.

Kurata Y, Tsumoto K, Hayashi K, Hisatome I, Tanida M, Kuda Y, Shibamoto T.

Am J Physiol Heart Circ Physiol. 2017 Jan 1;312(1):H106-H127. doi: 10.1152/ajpheart.00115.2016. Epub 2016 Nov 11.


BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes.

Feldman AM, Gordon J, Wang J, Song J, Zhang XQ, Myers VD, Tilley DG, Gao E, Hoffman NE, Tomar D, Madesh M, Rabinowitz J, Koch WJ, Su F, Khalili K, Cheung JY.

J Mol Cell Cardiol. 2016 Mar;92:10-20. doi: 10.1016/j.yjmcc.2016.01.015. Epub 2016 Jan 19.


The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome.

Qi X, Yeh YH, Chartier D, Xiao L, Tsuji Y, Brundel BJ, Kodama I, Nattel S.

Circ Arrhythm Electrophysiol. 2009 Jun;2(3):295-304. doi: 10.1161/CIRCEP.108.815654. Epub 2009 Apr 17.


Phospholemman and beta-adrenergic stimulation in the heart.

Wang J, Gao E, Song J, Zhang XQ, Li J, Koch WJ, Tucker AL, Philipson KD, Chan TO, Feldman AM, Cheung JY.

Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H807-15. doi: 10.1152/ajpheart.00877.2009. Epub 2009 Dec 11.


Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbits.

Liu GX, Choi BR, Ziv O, Li W, de Lange E, Qu Z, Koren G.

J Physiol. 2012 Mar 1;590(5):1171-80. doi: 10.1113/jphysiol.2011.218164. Epub 2011 Dec 19.


Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block.

Antoons G, Volders PG, Stankovicova T, Bito V, Stengl M, Vos MA, Sipido KR.

J Physiol. 2007 Feb 15;579(Pt 1):147-60. Epub 2006 Nov 30.


Slow [Na]i Changes and Positive Feedback Between Membrane Potential and [Ca]i Underlie Intermittent Early Afterdepolarizations and Arrhythmias.

Xie Y, Liao Z, Grandi E, Shiferaw Y, Bers DM.

Circ Arrhythm Electrophysiol. 2015 Dec;8(6):1472-80. doi: 10.1161/CIRCEP.115.003085. Epub 2015 Sep 25.


Increased Ca(2+) leak and spatiotemporal coherence of Ca(2+) release in cardiomyocytes during beta-adrenergic stimulation.

Ogrodnik J, Niggli E.

J Physiol. 2010 Jan 1;588(Pt 1):225-42. doi: 10.1113/jphysiol.2009.181800. Epub 2009 Nov 9.


Phospholemman-phosphorylation mediates the beta-adrenergic effects on Na/K pump function in cardiac myocytes.

Despa S, Bossuyt J, Han F, Ginsburg KS, Jia LG, Kutchai H, Tucker AL, Bers DM.

Circ Res. 2005 Aug 5;97(3):252-9. Epub 2005 Jul 7.


Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load.

Desantiago J, Ai X, Islam M, Acuna G, Ziolo MT, Bers DM, Pogwizd SM.

Circ Res. 2008 Jun 6;102(11):1389-97. doi: 10.1161/CIRCRESAHA.107.169011. Epub 2008 May 8.


Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents?

Zhao Z, Wen H, Fefelova N, Allen C, Baba A, Matsuda T, Xie LH.

Am J Physiol Heart Circ Physiol. 2012 Apr 15;302(8):H1636-44. doi: 10.1152/ajpheart.00742.2011. Epub 2012 Feb 3.


Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells.

Zhao Z, Xie Y, Wen H, Xiao D, Allen C, Fefelova N, Dun W, Boyden PA, Qu Z, Xie LH.

Cardiovasc Res. 2012 Aug 1;95(3):308-16. doi: 10.1093/cvr/cvs183. Epub 2012 Jun 1.


Hyperphosphorylation of RyRs underlies triggered activity in transgenic rabbit model of LQT2 syndrome.

Terentyev D, Rees CM, Li W, Cooper LL, Jindal HK, Peng X, Lu Y, Terentyeva R, Odening KE, Daley J, Bist K, Choi BR, Karma A, Koren G.

Circ Res. 2014 Nov 7;115(11):919-28. doi: 10.1161/CIRCRESAHA.115.305146. Epub 2014 Sep 23.


Endothelial nitric oxide synthase decreases beta-adrenergic responsiveness via inhibition of the L-type Ca2+ current.

Wang H, Kohr MJ, Wheeler DG, Ziolo MT.

Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1473-80. doi: 10.1152/ajpheart.01249.2007. Epub 2008 Jan 18.

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