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Items: 1 to 20 of 101

1.

Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection.

Evans BS, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW.

ACS Chem Biol. 2013 May 17;8(5):908-13. doi: 10.1021/cb400102t. Epub 2013 Mar 13.

2.

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes.

Ju KS, Gao J, Doroghazi JR, Wang KK, Thibodeaux CJ, Li S, Metzger E, Fudala J, Su J, Zhang JK, Lee J, Cioni JP, Evans BS, Hirota R, Labeda DP, van der Donk WA, Metcalf WW.

Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12175-80. doi: 10.1073/pnas.1500873112. Epub 2015 Aug 31.

3.

Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product.

Watanabe K, Hotta K, Nakaya M, Praseuth AP, Wang CC, Inada D, Takahashi K, Fukushi E, Oguri H, Oikawa H.

J Am Chem Soc. 2009 Jul 8;131(26):9347-53. doi: 10.1021/ja902261a.

4.

Albidopyrone, a new alpha-pyrone-containing metabolite from marine-derived Streptomyces sp. NTK 227.

Hohmann C, Schneider K, Bruntner C, Brown R, Jones AL, Goodfellow M, Krämer M, Imhoff JF, Nicholson G, Fiedler HP, Süssmuth RD.

J Antibiot (Tokyo). 2009 Feb;62(2):75-9. doi: 10.1038/ja.2008.15. Epub 2009 Jan 9.

PMID:
19132055
5.

Use and discovery of chemical elicitors that stimulate biosynthetic gene clusters in Streptomyces bacteria.

Moore JM, Bradshaw E, Seipke RF, Hutchings MI, McArthur M.

Methods Enzymol. 2012;517:367-85. doi: 10.1016/B978-0-12-404634-4.00018-8.

PMID:
23084948
6.

Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species.

Kim SY, Ju KS, Metcalf WW, Evans BS, Kuzuyama T, van der Donk WA.

Antimicrob Agents Chemother. 2012 Aug;56(8):4175-83. doi: 10.1128/AAC.06478-11. Epub 2012 May 21.

7.

Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster.

Woodyer RD, Shao Z, Thomas PM, Kelleher NL, Blodgett JA, Metcalf WW, van der Donk WA, Zhao H.

Chem Biol. 2006 Nov;13(11):1171-82.

8.

Genome mining-directed activation of a silent angucycline biosynthetic gene cluster in Streptomyces chattanoogensis.

Zhou Z, Xu Q, Bu Q, Guo Y, Liu S, Liu Y, Du Y, Li Y.

Chembiochem. 2015 Feb 9;16(3):496-502. doi: 10.1002/cbic.201402577. Epub 2014 Dec 15.

PMID:
25511454
9.

Identification and activation of novel biosynthetic gene clusters by genome mining in the kirromycin producer Streptomyces collinus Tü 365.

Iftime D, Kulik A, Härtner T, Rohrer S, Niedermeyer TH, Stegmann E, Weber T, Wohlleben W.

J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):277-91. doi: 10.1007/s10295-015-1685-7. Epub 2015 Oct 3.

PMID:
26433383
10.

Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster.

Gao J, Ju KS, Yu X, Velásquez JE, Mukherjee S, Lee J, Zhao C, Evans BS, Doroghazi JR, Metcalf WW, van der Donk WA.

Angew Chem Int Ed Engl. 2014 Jan 27;53(5):1334-7. doi: 10.1002/anie.201308363. Epub 2013 Dec 27.

11.

Artificial reconstruction of two cryptic angucycline antibiotic biosynthetic pathways.

Palmu K, Ishida K, Mäntsälä P, Hertweck C, Metsä-Ketelä M.

Chembiochem. 2007 Sep 3;8(13):1577-84.

PMID:
17654627
12.

Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans.

Young TS, Walsh CT.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13053-8. doi: 10.1073/pnas.1110435108. Epub 2011 Jul 25.

13.

Genome mining of Streptomyces ambofaciens.

Aigle B, Lautru S, Spiteller D, Dickschat JS, Challis GL, Leblond P, Pernodet JL.

J Ind Microbiol Biotechnol. 2014 Feb;41(2):251-63. doi: 10.1007/s10295-013-1379-y. Epub 2013 Nov 21. Review.

PMID:
24258629
14.

Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining.

Tang X, Li J, Millán-Aguiñaga N, Zhang JJ, O'Neill EC, Ugalde JA, Jensen PR, Mantovani SM, Moore BS.

ACS Chem Biol. 2015 Dec 18;10(12):2841-2849. doi: 10.1021/acschembio.5b00658. Epub 2015 Oct 21.

15.
16.

Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus.

Praseuth AP, Wang CC, Watanabe K, Hotta K, Oguri H, Oikawa H.

Biotechnol Prog. 2008 Nov-Dec;24(6):1226-31. doi: 10.1002/btpr.34.

PMID:
19194935
17.

Conserved biosynthetic pathways for phosalacine, bialaphos and newly discovered phosphonic acid natural products.

Blodgett JA, Zhang JK, Yu X, Metcalf WW.

J Antibiot (Tokyo). 2016 Jan;69(1):15-25. doi: 10.1038/ja.2015.77. Epub 2015 Sep 2.

18.

Cloning and characterization of the biosynthetic gene cluster for tomaymycin, an SJG-136 monomeric analog.

Li W, Chou S, Khullar A, Gerratana B.

Appl Environ Microbiol. 2009 May;75(9):2958-63. doi: 10.1128/AEM.02325-08. Epub 2009 Mar 6.

19.

Identification and analysis of the biosynthetic gene cluster encoding the thiopeptide antibiotic cyclothiazomycin in Streptomyces hygroscopicus 10-22.

Wang J, Yu Y, Tang K, Liu W, He X, Huang X, Deng Z.

Appl Environ Microbiol. 2010 Apr;76(7):2335-44. doi: 10.1128/AEM.01790-09. Epub 2010 Feb 12.

20.

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