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Spatiotemporal dynamics of early DNA damage response proteins on complex DNA lesions.

Tobias F, Löb D, Lengert N, Durante M, Drossel B, Taucher-Scholz G, Jakob B.

PLoS One. 2013;8(2):e57953. doi: 10.1371/journal.pone.0057953. Epub 2013 Feb 26.


Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention.

Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, Lerenthal Y, Jackson SP, Bartek J, Lukas J.

EMBO J. 2004 Jul 7;23(13):2674-83. Epub 2004 Jun 17.


A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin.

Hari FJ, Spycher C, Jungmichel S, Pavic L, Stucki M.

EMBO Rep. 2010 May;11(5):387-92. doi: 10.1038/embor.2010.30. Epub 2010 Mar 12.


Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage.

Chapman JR, Jackson SP.

EMBO Rep. 2008 Aug;9(8):795-801. doi: 10.1038/embor.2008.103. Epub 2008 Jun 27.


Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin.

Melander F, Bekker-Jensen S, Falck J, Bartek J, Mailand N, Lukas J.

J Cell Biol. 2008 Apr 21;181(2):213-26. doi: 10.1083/jcb.200708210. Epub 2008 Apr 14.


Live cell imaging of heavy-ion-induced radiation responses by beamline microscopy.

Jakob B, Rudolph JH, Gueven N, Lavin MF, Taucher-Scholz G.

Radiat Res. 2005 Jun;163(6):681-90.


Dancing on damaged chromatin: functions of ATM and the RAD50/MRE11/NBS1 complex in cellular responses to DNA damage.

Iijima K, Ohara M, Seki R, Tauchi H.

J Radiat Res. 2008 Sep;49(5):451-64. Epub 2008 Sep 4. Review.


Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity.

Hable V, Drexler GA, Brüning T, Burgdorf C, Greubel C, Derer A, Seel J, Strickfaden H, Cremer T, Friedl AA, Dollinger G.

PLoS One. 2012;7(7):e41943. doi: 10.1371/journal.pone.0041943. Epub 2012 Jul 30.


Regulation of ATM in DNA double strand break repair accounts for the radiosensitivity in human cells exposed to high linear energy transfer ionizing radiation.

Xue L, Yu D, Furusawa Y, Okayasu R, Tong J, Cao J, Fan S.

Mutat Res. 2009 Nov 2;670(1-2):15-23. doi: 10.1016/j.mrfmmm.2009.06.016. Epub 2009 Jul 5.


Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation.

Shi W, Ma Z, Willers H, Akhtar K, Scott SP, Zhang J, Powell S, Zhang J.

J Biol Chem. 2008 Nov 14;283(46):31608-16. doi: 10.1074/jbc.M801082200. Epub 2008 Aug 29.


Silencing of MBD1 reverses pancreatic cancer therapy resistance through inhibition of DNA damage repair.

Xu J, Zhu W, Xu W, Cui X, Chen L, Ji S, Qin Y, Yao W, Liu L, Liu C, Long J, Li M, Yu X.

Int J Oncol. 2013 Jun;42(6):2046-52. doi: 10.3892/ijo.2013.1901. Epub 2013 Apr 16.


Functional Role of NBS1 in Radiation Damage Response and Translesion DNA Synthesis.

Saito Y, Komatsu K.

Biomolecules. 2015 Aug 20;5(3):1990-2002. doi: 10.3390/biom5031990. Review.


Nucleolin participates in DNA double-strand break-induced damage response through MDC1-dependent pathway.

Kobayashi J, Fujimoto H, Sato J, Hayashi I, Burma S, Matsuura S, Chen DJ, Komatsu K.

PLoS One. 2012;7(11):e49245. doi: 10.1371/journal.pone.0049245. Epub 2012 Nov 7.


NBS1 and its functional role in the DNA damage response.

Kobayashi J, Antoccia A, Tauchi H, Matsuura S, Komatsu K.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):855-61. Review.


Subdiffusion supports joining of correct ends during repair of DNA double-strand breaks.

Girst S, Hable V, Drexler GA, Greubel C, Siebenwirth C, Haum M, Friedl AA, Dollinger G.

Sci Rep. 2013;3:2511. doi: 10.1038/srep02511.


The viral oncoprotein tax sequesters DNA damage response factors by tethering MDC1 to chromatin.

Belgnaoui SM, Fryrear KA, Nyalwidhe JO, Guo X, Semmes OJ.

J Biol Chem. 2010 Oct 22;285(43):32897-905. doi: 10.1074/jbc.M110.146373. Epub 2010 Aug 20.


Spatiotemporal analysis of DNA repair using charged particle radiation.

Tobias F, Durante M, Taucher-Scholz G, Jakob B.

Mutat Res. 2010 Apr-Jun;704(1-3):54-60. doi: 10.1016/j.mrrev.2009.11.004. Epub 2009 Nov 26. Review.


TopBP1 associates with NBS1 and is involved in homologous recombination repair.

Morishima K, Sakamoto S, Kobayashi J, Izumi H, Suda T, Matsumoto Y, Tauchi H, Ide H, Komatsu K, Matsuura S.

Biochem Biophys Res Commun. 2007 Nov 3;362(4):872-9. Epub 2007 Aug 24.


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