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Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair.

Marchetti B, L'Episcopo F, Morale MC, Tirolo C, Testa N, Caniglia S, Serapide MF, Pluchino S.

Eur J Neurosci. 2013 May;37(10):1550-63. doi: 10.1111/ejn.12166. Epub 2013 Mar 5. Review.


Reactive astrocytes are key players in nigrostriatal dopaminergic neurorepair in the MPTP mouse model of Parkinson's disease: focus on endogenous neurorestoration.

'Episcopo FL, Tirolo C, Testa N, Caniglia S, Morale MC, Marchetti B.

Curr Aging Sci. 2013 Feb;6(1):45-55. Review.


Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

L'Episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Cossetti C, D'Adamo P, Zardini E, Andreoni L, Ihekwaba AE, Serra PA, Franciotta D, Martino G, Pluchino S, Marchetti B.

Neurobiol Dis. 2011 Feb;41(2):508-27. doi: 10.1016/j.nbd.2010.10.023. Epub 2010 Nov 5. Erratum in: Neurobiol Dis.2011 Jun;42(3):539.


Microglia Polarization, Gene-Environment Interactions and Wnt/β-Catenin Signaling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Aged Parkinsonian Brain.

L'Episcopo F, Tirolo C, Serapide MF, Caniglia S, Testa N, Leggio L, Vivarelli S, Iraci N, Pluchino S, Marchetti B.

Front Aging Neurosci. 2018 Feb 12;10:12. doi: 10.3389/fnagi.2018.00012. eCollection 2018. Review.


A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection.

L'episcopo F, Serapide MF, Tirolo C, Testa N, Caniglia S, Morale MC, Pluchino S, Marchetti B.

Mol Neurodegener. 2011 Jul 13;6:49. doi: 10.1186/1750-1326-6-49.


Glia as a turning point in the therapeutic strategy of Parkinson's disease.

L' Episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Marchetti B.

CNS Neurol Disord Drug Targets. 2010 Jul;9(3):349-72. Review.


Wnt/β-catenin signaling is required to rescue midbrain dopaminergic progenitors and promote neurorepair in ageing mouse model of Parkinson's disease.

L'Episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Serapide MF, Pluchino S, Marchetti B.

Stem Cells. 2014 Aug;32(8):2147-63. doi: 10.1002/stem.1708.


Wnt/β-catenin signaling plays an essential role in α7 nicotinic receptor-mediated neuroprotection of dopaminergic neurons in a mouse Parkinson's disease model.

Liu Y, Hao S, Yang B, Fan Y, Qin X, Chen Y, Hu J.

Biochem Pharmacol. 2017 Sep 15;140:115-123. doi: 10.1016/j.bcp.2017.05.017. Epub 2017 May 25.


Systemically administered neuregulin-1β1 rescues nigral dopaminergic neurons via the ErbB4 receptor tyrosine kinase in MPTP mouse models of Parkinson's disease.

Depboylu C, Rösler TW, de Andrade A, Oertel WH, Höglinger GU.

J Neurochem. 2015 May;133(4):590-7. doi: 10.1111/jnc.13026. Epub 2015 Jan 26.


Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease.

L'Episcopo F, Tirolo C, Caniglia S, Testa N, Morale MC, Serapide MF, Pluchino S, Marchetti B.

J Mol Cell Biol. 2014 Feb;6(1):13-26. doi: 10.1093/jmcb/mjt053. Epub 2014 Jan 14. Review.


Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease.

Hu X, Zhang D, Pang H, Caudle WM, Li Y, Gao H, Liu Y, Qian L, Wilson B, Di Monte DA, Ali SF, Zhang J, Block ML, Hong JS.

J Immunol. 2008 Nov 15;181(10):7194-204.


α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation.

Liu Y, Hu J, Wu J, Zhu C, Hui Y, Han Y, Huang Z, Ellsworth K, Fan W.

J Neuroinflammation. 2012 May 24;9:98. doi: 10.1186/1742-2094-9-98.


Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

L'Episcopo F, Tirolo C, Caniglia S, Testa N, Serra PA, Impagnatiello F, Morale MC, Marchetti B.

J Neuroinflammation. 2010 Nov 23;7:83. doi: 10.1186/1742-2094-7-83.


Aging-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt/β-catenin dysregulation.

L'Episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Impagnatiello F, Pluchino S, Marchetti B.

J Neurosci. 2013 Jan 23;33(4):1462-85. doi: 10.1523/JNEUROSCI.3206-12.2013.


Hormones are key actors in gene x environment interactions programming the vulnerability to Parkinson's disease: glia as a common final pathway.

Marchetti B, Serra PA, L'Episcopo F, Tirolo C, Caniglia S, Testa N, Cioni S, Gennuso F, Rocchitta G, Desole MS, Mazzarino MC, Miele E, Morale MC.

Ann N Y Acad Sci. 2005 Dec;1057:296-318. Review.


Estrogen, neuroinflammation and neuroprotection in Parkinson's disease: glia dictates resistance versus vulnerability to neurodegeneration.

Morale MC, Serra PA, L'episcopo F, Tirolo C, Caniglia S, Testa N, Gennuso F, Giaquinta G, Rocchitta G, Desole MS, Miele E, Marchetti B.

Neuroscience. 2006;138(3):869-78. Epub 2005 Dec 5. Review.


Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP.

Schildknecht S, Di Monte DA, Pape R, Tieu K, Leist M.

Trends Pharmacol Sci. 2017 Jun;38(6):541-555. doi: 10.1016/ Epub 2017 Apr 23. Review.


The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration.

Drouin-Ouellet J, Gibrat C, Bousquet M, Calon F, Kriz J, Cicchetti F.

J Neuroinflammation. 2011 Oct 11;8:137. doi: 10.1186/1742-2094-8-137.


Modeling early Parkinson's disease pathology with chronic low dose MPTP treatment.

Korecka JA, Eggers R, Swaab DF, Bossers K, Verhaagen J.

Restor Neurol Neurosci. 2013;31(2):155-67. doi: 10.3233/RNN-110222.


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