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Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion.

Mou Z, Muleme HM, Liu D, Jia P, Okwor IB, Kuriakose SM, Beverley SM, Uzonna JE.

J Immunol. 2013 Apr 1;190(7):3380-9. doi: 10.4049/jimmunol.1202537. Epub 2013 Mar 4.


Infection with arginase-deficient Leishmania major reveals a parasite number-dependent and cytokine-independent regulation of host cellular arginase activity and disease pathogenesis.

Muleme HM, Reguera RM, Berard A, Azinwi R, Jia P, Okwor IB, Beverley S, Uzonna JE.

J Immunol. 2009 Dec 15;183(12):8068-76. doi: 10.4049/jimmunol.0803979.


L-arginine deprivation impairs Leishmania major-specific T-cell responses.

Munder M, Choi BS, Rogers M, Kropf P.

Eur J Immunol. 2009 Aug;39(8):2161-72. doi: 10.1002/eji.200839041.


Arginase activity in pathogenic and non-pathogenic species of Leishmania parasites.

Badirzadeh A, Taheri T, Taslimi Y, Abdossamadi Z, Heidari-Kharaji M, Gholami E, Sedaghat B, Niyyati M, Rafati S.

PLoS Negl Trop Dis. 2017 Jul 14;11(7):e0005774. doi: 10.1371/journal.pntd.0005774. eCollection 2017 Jul.


CD8+ T cells are preferentially activated during primary low dose leishmania major infection but are completely dispensable during secondary anti-Leishmania immunity.

Okwor IB, Jia P, Mou Z, Onyilagha C, Uzonna JE.

PLoS Negl Trop Dis. 2014 Nov 20;8(11):e3300. doi: 10.1371/journal.pntd.0003300. eCollection 2014.


Age-related alteration of arginase activity impacts on severity of leishmaniasis.

Müller I, Hailu A, Choi BS, Abebe T, Fuentes JM, Munder M, Modolell M, Kropf P.

PLoS Negl Trop Dis. 2008 May 14;2(5):e235. doi: 10.1371/journal.pntd.0000235.


Proapoptotic Bcl-2 family member Bim promotes persistent infection and limits protective immunity.

Reckling S, Divanovic S, Karp CL, Wojciechowski S, Belkaid Y, Hildeman D.

Infect Immun. 2008 Mar;76(3):1179-85. Epub 2007 Dec 17.


CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major.

Belkaid Y, Von Stebut E, Mendez S, Lira R, Caler E, Bertholet S, Udey MC, Sacks D.

J Immunol. 2002 Apr 15;168(8):3992-4000.


Inoculation of killed Leishmania major into immune mice rapidly disrupts immunity to a secondary challenge via IL-10-mediated process.

Okwor I, Liu D, Beverley SM, Uzonna JE.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13951-6. doi: 10.1073/pnas.0905184106. Epub 2009 Aug 6.


Expression of PD-1/LAG-3 and cytokine production by CD4(+) T cells during infection with Plasmodium parasites.

Doe HT, Kimura D, Miyakoda M, Kimura K, Akbari M, Yui K.

Microbiol Immunol. 2016 Feb;60(2):121-31. doi: 10.1111/1348-0421.12354.


Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites.

Zaph C, Uzonna J, Beverley SM, Scott P.

Nat Med. 2004 Oct;10(10):1104-10. Epub 2004 Sep 26.


Leishmania-encoded orthologs of macrophage migration inhibitory factor regulate host immunity to promote parasite persistence.

Holowka T, Castilho TM, Garcia AB, Sun T, McMahon-Pratt D, Bucala R.

FASEB J. 2016 Jun;30(6):2249-65. doi: 10.1096/fj.201500189R. Epub 2016 Mar 8.


The early generation of a heterogeneous CD4+ T cell response to Leishmania major.

Colpitts SL, Scott P.

J Immunol. 2010 Aug 15;185(4):2416-23. doi: 10.4049/jimmunol.1000483. Epub 2010 Jul 12.


Myeloid-derived suppressor cell functionality and interaction with Leishmania major parasites differ in C57BL/6 and BALB/c mice.

Schmid M, Zimara N, Wege AK, Ritter U.

Eur J Immunol. 2014 Nov;44(11):3295-306. doi: 10.1002/eji.201344335. Epub 2014 Sep 19.


Lymphotoxin alpha beta 2 (membrane lymphotoxin) is critically important for resistance to Leishmania major infection in mice.

Xu G, Liu D, Fan Y, Yang X, Korner H, Fu YX, Uzonna JE.

J Immunol. 2007 Oct 15;179(8):5358-66. Erratum in: J Immunol. 2007 Nov 15;179(10):7185.


MHC class II restricted innate-like double negative T cells contribute to optimal primary and secondary immunity to Leishmania major.

Mou Z, Liu D, Okwor I, Jia P, Orihara K, Uzonna JE.

PLoS Pathog. 2014 Sep 18;10(9):e1004396. doi: 10.1371/journal.ppat.1004396. eCollection 2014 Sep.

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