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Items: 1 to 20 of 143


Targeting B-cell anergy in chronic lymphocytic leukemia.

Apollonio B, Scielzo C, Bertilaccio MT, Ten Hacken E, Scarfò L, Ranghetti P, Stevenson F, Packham G, Ghia P, Muzio M, Caligaris-Cappio F.

Blood. 2013 May 9;121(19):3879-88, S1-8. doi: 10.1182/blood-2012-12-474718. Epub 2013 Mar 4.


Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

Petlickovski A, Laurenti L, Li X, Marietti S, Chiusolo P, Sica S, Leone G, Efremov DG.

Blood. 2005 Jun 15;105(12):4820-7. Epub 2005 Feb 22.


Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy.

Muzio M, Apollonio B, Scielzo C, Frenquelli M, Vandoni I, Boussiotis V, Caligaris-Cappio F, Ghia P.

Blood. 2008 Jul 1;112(1):188-95. doi: 10.1182/blood-2007-09-111344. Epub 2008 Feb 21.


Signaling pathways activated by antigen-receptor engagement in chronic lymphocytic leukemia B-cells.

Efremov DG, Gobessi S, Longo PG.

Autoimmun Rev. 2007 Dec;7(2):102-8. Epub 2007 Mar 28. Review.


The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy.

Packham G, Krysov S, Allen A, Savelyeva N, Steele AJ, Forconi F, Stevenson FK.

Haematologica. 2014 Jul;99(7):1138-48. doi: 10.3324/haematol.2013.098384. Review.


Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells.

Gobessi S, Laurenti L, Longo PG, Carsetti L, Berno V, Sica S, Leone G, Efremov DG.

Leukemia. 2009 Apr;23(4):686-97. doi: 10.1038/leu.2008.346. Epub 2008 Dec 18.


Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy.

Bléry M, Tze L, Miosge LA, Jun JE, Goodnow CC.

J Exp Med. 2006 Jul 10;203(7):1773-83. Epub 2006 Jun 26.


Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia.

Chen L, Widhopf G, Huynh L, Rassenti L, Rai KR, Weiss A, Kipps TJ.

Blood. 2002 Dec 15;100(13):4609-14. Epub 2002 Aug 8.


The degree of BCR and NFAT activation predicts clinical outcomes in chronic lymphocytic leukemia.

Le Roy C, Deglesne PA, Chevallier N, Beitar T, Eclache V, Quettier M, Boubaya M, Letestu R, Lévy V, Ajchenbaum-Cymbalista F, Varin-Blank N.

Blood. 2012 Jul 12;120(2):356-65. doi: 10.1182/blood-2011-12-397158. Epub 2012 May 21.


B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406.

Quiroga MP, Balakrishnan K, Kurtova AV, Sivina M, Keating MJ, Wierda WG, Gandhi V, Burger JA.

Blood. 2009 Jul 30;114(5):1029-37. doi: 10.1182/blood-2009-03-212837. Epub 2009 Jun 2.


Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells.

Suljagic M, Laurenti L, Tarnani M, Alam M, Malek SN, Efremov DG.

Leukemia. 2010 Dec;24(12):2063-71. doi: 10.1038/leu.2010.201. Epub 2010 Sep 23.


The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells.

Longo PG, Laurenti L, Gobessi S, Sica S, Leone G, Efremov DG.

Blood. 2008 Jan 15;111(2):846-55. Epub 2007 Oct 10.


Antigen receptor nonresponsiveness in chronic lymphocytic leukemia B cells.

Lankester AC, van Schijndel GM, van der Schoot CE, van Oers MH, van Noesel CJ, van Lier RA.

Blood. 1995 Aug 1;86(3):1090-7.


Targeted therapy in chronic lymphocytic leukemia: past, present, and future.

Danilov AV.

Clin Ther. 2013 Sep;35(9):1258-70. doi: 10.1016/j.clinthera.2013.08.004. Review.


Aberrant B cell receptor signaling from B29 (Igbeta, CD79b) gene mutations of chronic lymphocytic leukemia B cells.

Gordon MS, Kato RM, Lansigan F, Thompson AA, Wall R, Rawlings DJ.

Proc Natl Acad Sci U S A. 2000 May 9;97(10):5504-9.


Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia.

ten Hacken E, Scielzo C, Bertilaccio MT, Scarfò L, Apollonio B, Barbaglio F, Stamatopoulos K, Ponzoni M, Ghia P, Caligaris-Cappio F.

Blood. 2013 Mar 21;121(12):2264-73. doi: 10.1182/blood-2012-09-457119. Epub 2013 Jan 16.


B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia.

Allsup DJ, Kamiguti AS, Lin K, Sherrington PD, Matrai Z, Slupsky JR, Cawley JC, Zuzel M.

Cancer Res. 2005 Aug 15;65(16):7328-37.


Signaling pathways activated by the B-cell receptor in chronic lymphocytic leukemia.

Scupoli MT, Pizzolo G.

Expert Rev Hematol. 2012 Jun;5(3):341-8. doi: 10.1586/ehm.12.21. Review.


Survival of the weak (signalers): anergy in CLL.

Woyach JA.

Blood. 2013 May 9;121(19):3781-3. doi: 10.1182/blood-2013-03-489849. No abstract available.

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