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Mutational activation of the AmgRS two-component system in aminoglycoside-resistant Pseudomonas aeruginosa.

Lau CH, Fraud S, Jones M, Peterson SN, Poole K.

Antimicrob Agents Chemother. 2013 May;57(5):2243-51. doi: 10.1128/AAC.00170-13. Epub 2013 Mar 4.


AmgRS-mediated envelope stress-inducible expression of the mexXY multidrug efflux operon of Pseudomonas aeruginosa.

Lau CH, Krahn T, Gilmour C, Mullen E, Poole K.

Microbiologyopen. 2015 Feb;4(1):121-35. doi: 10.1002/mbo3.226. Epub 2014 Dec 1.


Reduced expression of the rplU-rpmA ribosomal protein operon in mexXY-expressing pan-aminoglycoside-resistant mutants of pseudomonas aeruginosa.

Lau CH, Fraud S, Jones M, Peterson SN, Poole K.

Antimicrob Agents Chemother. 2012 Oct;56(10):5171-9. doi: 10.1128/AAC.00846-12. Epub 2012 Jul 23.


Role of the MexXY multidrug efflux pump in moderate aminoglycoside resistance in Pseudomonas aeruginosa isolates from Pseudomonas mastitis.

Chuanchuen R, Wannaprasat W, Ajariyakhajorn K, Schweizer HP.

Microbiol Immunol. 2008 Aug;52(8):392-8. doi: 10.1111/j.1348-0421.2008.00051.x.


Targeting a bacterial stress response to enhance antibiotic action.

Lee S, Hinz A, Bauerle E, Angermeyer A, Juhaszova K, Kaneko Y, Singh PK, Manoil C.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14570-5. doi: 10.1073/pnas.0903619106. Epub 2009 Aug 12.


Aminoglycoside resistance mechanisms in Pseudomonas aeruginosa isolates from non-cystic fibrosis patients in Thailand.

Poonsuk K, Tribuddharat C, Chuanchuen R.

Can J Microbiol. 2013 Jan;59(1):51-6. doi: 10.1139/cjm-2012-0465. Epub 2012 Nov 19.


Determinants of intrinsic aminoglycoside resistance in Pseudomonas aeruginosa.

Krahn T, Gilmour C, Tilak J, Fraud S, Kerr N, Lau CH, Poole K.

Antimicrob Agents Chemother. 2012 Nov;56(11):5591-602. doi: 10.1128/AAC.01446-12. Epub 2012 Aug 20.


Polymyxin resistance of Pseudomonas aeruginosa phoQ mutants is dependent on additional two-component regulatory systems.

Gutu AD, Sgambati N, Strasbourger P, Brannon MK, Jacobs MA, Haugen E, Kaul RK, Johansen HK, Høiby N, Moskowitz SM.

Antimicrob Agents Chemother. 2013 May;57(5):2204-15. doi: 10.1128/AAC.02353-12. Epub 2013 Mar 4.


Genetic and phenotypic variations of a resistant Pseudomonas aeruginosa epidemic clone.

Hocquet D, Bertrand X, Köhler T, Talon D, Plésiat P.

Antimicrob Agents Chemother. 2003 Jun;47(6):1887-94.


Membrane proteases and aminoglycoside antibiotic resistance.

Hinz A, Lee S, Jacoby K, Manoil C.

J Bacteriol. 2011 Sep;193(18):4790-7. doi: 10.1128/JB.05133-11. Epub 2011 Jul 15.


Extracellular DNA Acidifies Biofilms and Induces Aminoglycoside Resistance in Pseudomonas aeruginosa.

Wilton M, Charron-Mazenod L, Moore R, Lewenza S.

Antimicrob Agents Chemother. 2015 Nov 9;60(1):544-53. doi: 10.1128/AAC.01650-15.


Oxidative stress induction of the MexXY multidrug efflux genes and promotion of aminoglycoside resistance development in Pseudomonas aeruginosa.

Fraud S, Poole K.

Antimicrob Agents Chemother. 2011 Mar;55(3):1068-74. doi: 10.1128/AAC.01495-10. Epub 2010 Dec 20.


Expression of the MexXY efflux pump in amikacin-resistant isolates of Pseudomonas aeruginosa.

Islam S, Jalal S, Wretlind B.

Clin Microbiol Infect. 2004 Oct;10(10):877-83.


Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.

Vettoretti L, Plésiat P, Muller C, El Garch F, Phan G, Attrée I, Ducruix A, Llanes C.

Antimicrob Agents Chemother. 2009 May;53(5):1987-97. doi: 10.1128/AAC.01024-08. Epub 2009 Mar 2.


A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and β-lactams in Pseudomonas aeruginosa.

Muller C, Plésiat P, Jeannot K.

Antimicrob Agents Chemother. 2011 Mar;55(3):1211-21. doi: 10.1128/AAC.01252-10. Epub 2010 Dec 13.


Multiple mutations lead to MexXY-OprM-dependent aminoglycoside resistance in clinical strains of Pseudomonas aeruginosa.

Guénard S, Muller C, Monlezun L, Benas P, Broutin I, Jeannot K, Plésiat P.

Antimicrob Agents Chemother. 2014;58(1):221-8. doi: 10.1128/AAC.01252-13. Epub 2013 Oct 21. Erratum in: Antimicrob Agents Chemother. 2014 Mar;58(3):1833.


Beta-lactam and aminoglycoside resistance rates and mechanisms among Pseudomonas aeruginosa in French general practice (community and private healthcare centres).

Dubois V, Arpin C, Dupart V, Scavelli A, Coulange L, André C, Fischer I, Grobost F, Brochet JP, Lagrange I, Dutilh B, Jullin J, Noury P, Larribet G, Quentin C.

J Antimicrob Chemother. 2008 Aug;62(2):316-23. doi: 10.1093/jac/dkn174. Epub 2008 May 8.


Phenotypic and genome-wide analysis of an antibiotic-resistant small colony variant (SCV) of Pseudomonas aeruginosa.

Wei Q, Tarighi S, Dötsch A, Häussler S, Müsken M, Wright VJ, Cámara M, Williams P, Haenen S, Boerjan B, Bogaerts A, Vierstraete E, Verleyen P, Schoofs L, Willaert R, De Groote VN, Michiels J, Vercammen K, Crabbé A, Cornelis P.

PLoS One. 2011;6(12):e29276. doi: 10.1371/journal.pone.0029276. Epub 2011 Dec 15.

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