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ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins.

Fröhlich C, Klitgaard M, Noer JB, Kotzsch A, Nehammer C, Kronqvist P, Berthelsen J, Blobel C, Kveiborg M, Albrechtsen R, Wewer UM.

Biochem J. 2013 May 15;452(1):97-109. doi: 10.1042/BJ20121558.


Functional analysis of a breast cancer-associated mutation in the intracellular domain of the metalloprotease ADAM12.

Stautz D, Wewer UM, Kveiborg M.

PLoS One. 2012;7(5):e37628. doi: 10.1371/journal.pone.0037628. Epub 2012 May 25.


PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor.

Mori S, Tanaka M, Nanba D, Nishiwaki E, Ishiguro H, Higashiyama S, Matsuura N.

J Biol Chem. 2003 Nov 14;278(46):46029-34. Epub 2003 Sep 2.


ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression.

Fröhlich C, Nehammer C, Albrechtsen R, Kronqvist P, Kveiborg M, Sehara-Fujisawa A, Mercurio AM, Wewer UM.

Mol Cancer Res. 2011 Nov;9(11):1449-61. doi: 10.1158/1541-7786.MCR-11-0100. Epub 2011 Aug 29.


ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion.

Aghababaei M, Hogg K, Perdu S, Robinson WP, Beristain AG.

Cell Death Differ. 2015 Dec;22(12):1970-84. doi: 10.1038/cdd.2015.44. Epub 2015 Apr 24.


Cell-surface metalloprotease ADAM12 is internalized by a clathrin- and Grb2-dependent mechanism.

Stautz D, Leyme A, Grandal MV, Albrechtsen R, van Deurs B, Wewer U, Kveiborg M.

Traffic. 2012 Nov;13(11):1532-46. doi: 10.1111/j.1600-0854.2012.01405.x. Epub 2012 Sep 10.


ADAM12 and ADAM17 gene expression in laser-capture microdissected and non-microdissected breast tumors.

Narita D, Seclaman E, Ilina R, Cireap N, Ursoniu S, Anghel A.

Pathol Oncol Res. 2011 Jun;17(2):375-85. doi: 10.1007/s12253-010-9336-9. Epub 2011 Jan 16.


Cellular roles of ADAM12 in health and disease.

Kveiborg M, Albrechtsen R, Couchman JR, Wewer UM.

Int J Biochem Cell Biol. 2008;40(9):1685-702. doi: 10.1016/j.biocel.2008.01.025. Epub 2008 Feb 1. Review.


Mitogen-activated protein kinase (MAPK) regulates leukotriene D4-induced HB-EGF and ADAM12 expression in human airway smooth muscle cells.

Kumasawa F, Hashimoto S, Mizumura K, Takeshita I, Onose A, Jibiki I, Maruoka S, Gon Y, Kobayashi T, Takahashi N.

Asian Pac J Allergy Immunol. 2013 Mar;31(1):58-66.


ADAM12-L is a direct target of the miR-29 and miR-200 families in breast cancer.

Duhachek-Muggy S, Zolkiewska A.

BMC Cancer. 2015 Mar 4;15:93. doi: 10.1186/s12885-015-1108-1.


Regulation of ADAM12 cell-surface expression by protein kinase C epsilon.

Sundberg C, Thodeti CK, Kveiborg M, Larsson C, Parker P, Albrechtsen R, Wewer UM.

J Biol Chem. 2004 Dec 3;279(49):51601-11. Epub 2004 Sep 13.


Lysophosphatidic acid-induced ADAM12 expression mediates human adipose tissue-derived mesenchymal stem cell-stimulated tumor growth.

Do EK, Kim YM, Heo SC, Kwon YW, Shin SH, Suh DS, Kim KH, Yoon MS, Kim JH.

Int J Biochem Cell Biol. 2012 Nov;44(11):2069-76. doi: 10.1016/j.biocel.2012.08.004. Epub 2012 Aug 10.


Angiomodulin, a marker of cancer vasculature, is upregulated by vascular endothelial growth factor and increases vascular permeability as a ligand of integrin αvβ3.

Komiya E, Sato H, Watanabe N, Ise M, Higashi S, Miyagi Y, Miyazaki K.

Cancer Med. 2014 Jun;3(3):537-49. doi: 10.1002/cam4.216. Epub 2014 Apr 16.


ADAM12-cleaved ephrin-A1 contributes to lung metastasis.

Ieguchi K, Tomita T, Omori T, Komatsu A, Deguchi A, Masuda J, Duffy SL, Coulthard MG, Boyd A, Maru Y.

Oncogene. 2014 Apr 24;33(17):2179-90. doi: 10.1038/onc.2013.180. Epub 2013 May 20.


[Membrane-anchored heparin-binding EGF-like growth factor processing by ADAM12 in cardiac hypertrophy].

Higashiyama S.

Nihon Rinsho. 2003 May;61(5):767-75. Review. Japanese.


ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor.

Kodama T, Ikeda E, Okada A, Ohtsuka T, Shimoda M, Shiomi T, Yoshida K, Nakada M, Ohuchi E, Okada Y.

Am J Pathol. 2004 Nov;165(5):1743-53.


Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity.

Albrechtsen R, Stautz D, Sanjay A, Kveiborg M, Wewer UM.

Exp Cell Res. 2011 Jan 15;317(2):195-209. doi: 10.1016/j.yexcr.2010.10.003. Epub 2010 Oct 14.


ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin.

Schulz B, Pruessmeyer J, Maretzky T, Ludwig A, Blobel CP, Saftig P, Reiss K.

Circ Res. 2008 May 23;102(10):1192-201. doi: 10.1161/CIRCRESAHA.107.169805. Epub 2008 Apr 17.


ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties.

Rose AA, Annis MG, Dong Z, Pepin F, Hallett M, Park M, Siegel PM.

PLoS One. 2010 Aug 10;5(8):e12093. doi: 10.1371/journal.pone.0012093.


Molecular profiling of ADAM12 gene in breast cancers.

Nariţa D, Anghel A, Seclaman E, Ilina R, Cireap N, Ursoniu S.

Rom J Morphol Embryol. 2010;51(4):669-76.

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