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The Legionella pneumophila Dot/Icm-secreted effector PlcC/CegC1 together with PlcA and PlcB promotes virulence and belongs to a novel zinc metallophospholipase C family present in bacteria and fungi.

Aurass P, Schlegel M, Metwally O, Harding CR, Schroeder GN, Frankel G, Flieger A.

J Biol Chem. 2013 Apr 19;288(16):11080-92. doi: 10.1074/jbc.M112.426049.


bdhA-patD operon as a virulence determinant, revealed by a novel large-scale approach for identification of Legionella pneumophila mutants defective for amoeba infection.

Aurass P, Pless B, Rydzewski K, Holland G, Bannert N, Flieger A.

Appl Environ Microbiol. 2009 Jul;75(13):4506-15. doi: 10.1128/AEM.00187-09.


Legionella pneumophila strain 130b possesses a unique combination of type IV secretion systems and novel Dot/Icm secretion system effector proteins.

Schroeder GN, Petty NK, Mousnier A, Harding CR, Vogrin AJ, Wee B, Fry NK, Harrison TG, Newton HJ, Thomson NR, Beatson SA, Dougan G, Hartland EL, Frankel G.

J Bacteriol. 2010 Nov;192(22):6001-16. doi: 10.1128/JB.00778-10.


Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila.

Fontana MF, Banga S, Barry KC, Shen X, Tan Y, Luo ZQ, Vance RE.

PLoS Pathog. 2011 Feb;7(2):e1001289. doi: 10.1371/journal.ppat.1001289.


Legionella pneumophila genes that encode lipase and phospholipase C activities.

Aragon V, Rossier O, Cianciotto NP.

Microbiology. 2002 Jul;148(Pt 7):2223-31.


Implication of proteins containing tetratricopeptide repeats in conditional virulence phenotypes of Legionella pneumophila.

Bandyopadhyay P, Sumer EU, Jayakumar D, Liu S, Xiao H, Steinman HM.

J Bacteriol. 2012 Jul;194(14):3579-88. doi: 10.1128/JB.00399-12.


Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor.

Schroeder GN, Aurass P, Oates CV, Tate EW, Hartland EL, Flieger A, Frankel G.

Infect Immun. 2015 Oct;83(10):3989-4002. doi: 10.1128/IAI.00785-15.


Implication of the VirD4 coupling protein of the Lvh type 4 secretion system in virulence phenotypes of Legionella pneumophila.

Bandyopadhyay P, Lang EA, Rasaputra KS, Steinman HM.

J Bacteriol. 2013 Aug;195(15):3468-75. doi: 10.1128/JB.00430-13.


Sel1 repeat protein LpnE is a Legionella pneumophila virulence determinant that influences vacuolar trafficking.

Newton HJ, Sansom FM, Dao J, McAlister AD, Sloan J, Cianciotto NP, Hartland EL.

Infect Immun. 2007 Dec;75(12):5575-85.


A Legionella pneumophila effector protein encoded in a region of genomic plasticity binds to Dot/Icm-modified vacuoles.

Ninio S, Celli J, Roy CR.

PLoS Pathog. 2009 Jan;5(1):e1000278. doi: 10.1371/journal.ppat.1000278.


A Dot/Icm-translocated ankyrin protein of Legionella pneumophila is required for intracellular proliferation within human macrophages and protozoa.

Al-Khodor S, Price CT, Habyarimana F, Kalia A, Abu Kwaik Y.

Mol Microbiol. 2008 Nov;70(4):908-23. doi: 10.1111/j.1365-2958.2008.06453.x.


The manifold phospholipases A of Legionella pneumophila - identification, export, regulation, and their link to bacterial virulence.

Banerji S, Aurass P, Flieger A.

Int J Med Microbiol. 2008 Apr;298(3-4):169-81. doi: 10.1016/j.ijmm.2007.11.004. Review.


Legionella pneumophila Dot/Icm translocated substrates: a sum of parts.

Ensminger AW, Isberg RR.

Curr Opin Microbiol. 2009 Feb;12(1):67-73. doi: 10.1016/j.mib.2008.12.004. Review.


Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila.

Brombacher E, Urwyler S, Ragaz C, Weber SS, Kami K, Overduin M, Hilbi H.

J Biol Chem. 2009 Feb 20;284(8):4846-56. doi: 10.1074/jbc.M807505200.


Phospholipase PlaB of Legionella pneumophila represents a novel lipase family: protein residues essential for lipolytic activity, substrate specificity, and hemolysis.

Bender J, Rydzewski K, Broich M, Schunder E, Heuner K, Flieger A.

J Biol Chem. 2009 Oct 2;284(40):27185-94. doi: 10.1074/jbc.M109.026021.


The Dot/Icm effector SdhA is necessary for virulence of Legionella pneumophila in Galleria mellonella and A/J mice.

Harding CR, Stoneham CA, Schuelein R, Newton H, Oates CV, Hartland EL, Schroeder GN, Frankel G.

Infect Immun. 2013 Jul;81(7):2598-605. doi: 10.1128/IAI.00296-13.

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