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Items: 1 to 20 of 117


Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel β1-subunit by a novel nonsteroidal agent.

Bukiya AN, McMillan JE, Fedinec AL, Patil SA, Miller DD, Leffler CW, Parrill AL, Dopico AM.

Mol Pharmacol. 2013 May;83(5):1030-44. doi: 10.1124/mol.112.083519. Epub 2013 Mar 1.


The steroid interaction site in transmembrane domain 2 of the large conductance, voltage- and calcium-gated potassium (BK) channel accessory β1 subunit.

Bukiya AN, Singh AK, Parrill AL, Dopico AM.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20207-12. doi: 10.1073/pnas.1112901108. Epub 2011 Nov 28.


Channel beta2-4 subunits fail to substitute for beta1 in sensitizing BK channels to lithocholate.

Bukiya AN, Vaithianathan T, Toro L, Dopico AM.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):995-1000. doi: 10.1016/j.bbrc.2009.10.091. Epub 2009 Oct 21.


Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4.

Bukiya AN, McMillan J, Liu J, Shivakumar B, Parrill AL, Dopico AM.

J Biol Chem. 2014 Dec 19;289(51):35314-25. doi: 10.1074/jbc.M114.577825. Epub 2014 Nov 4.


Smooth muscle cholesterol enables BK β1 subunit-mediated channel inhibition and subsequent vasoconstriction evoked by alcohol.

Bukiya AN, Vaithianathan T, Kuntamallappanavar G, Asuncion-Chin M, Dopico AM.

Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2410-23. doi: 10.1161/ATVBAHA.111.233965.


Equol increases cerebral blood flow in rats via activation of large-conductance Ca(2+)-activated K(+) channels in vascular smooth muscle cells.

Yu W, Wang Y, Song Z, Zhao LM, Li GR, Deng XL.

Pharmacol Res. 2016 May;107:186-94. doi: 10.1016/j.phrs.2016.03.015. Epub 2016 Mar 16.


Daidzein relaxes rat cerebral basilar artery via activation of large-conductance Ca2+-activated K+ channels in vascular smooth muscle cells.

Zhang HT, Wang Y, Deng XL, Dong MQ, Zhao LM, Wang YW.

Eur J Pharmacol. 2010 Mar 25;630(1-3):100-6. doi: 10.1016/j.ejphar.2009.12.032. Epub 2010 Jan 5.


Differential distribution and functional impact of BK channel beta1 subunits across mesenteric, coronary, and different cerebral arteries of the rat.

Kuntamallappanavar G, Bisen S, Bukiya AN, Dopico AM.

Pflugers Arch. 2017 Feb;469(2):263-277. doi: 10.1007/s00424-016-1929-z. Epub 2016 Dec 24.


The BK channel accessory beta1 subunit determines alcohol-induced cerebrovascular constriction.

Bukiya AN, Liu J, Dopico AM.

FEBS Lett. 2009 Sep 3;583(17):2779-84. doi: 10.1016/j.febslet.2009.07.019. Epub 2009 Jul 17.


Both transmembrane domains of BK β1 subunits are essential to confer the normal phenotype of β1-containing BK channels.

Kuntamallappanavar G, Toro L, Dopico AM.

PLoS One. 2014 Oct 2;9(10):e109306. doi: 10.1371/journal.pone.0109306. eCollection 2014.


Pituitary adenylate cyclase activating polypeptide (PACAP) dilates cerebellar arteries through activation of large-conductance Ca(2+)-activated (BK) and ATP-sensitive (K ATP) K (+) channels.

Koide M, Syed AU, Braas KM, May V, Wellman GC.

J Mol Neurosci. 2014 Nov;54(3):443-50. doi: 10.1007/s12031-014-0301-z. Epub 2014 Apr 18.


Activation of BKCa channel is associated with increased apoptosis of cerebrovascular smooth muscle cells in simulated microgravity rats.

Xie MJ, Ma YG, Gao F, Bai YG, Cheng JH, Chang YM, Yu ZB, Ma J.

Am J Physiol Cell Physiol. 2010 Jun;298(6):C1489-500. doi: 10.1152/ajpcell.00474.2009. Epub 2010 Mar 24.


Direct regulation of BK channels by phosphatidylinositol 4,5-bisphosphate as a novel signaling pathway.

Vaithianathan T, Bukiya A, Liu J, Liu P, Asuncion-Chin M, Fan Z, Dopico A.

J Gen Physiol. 2008 Jul;132(1):13-28. doi: 10.1085/jgp.200709913. Epub 2008 Jun 18.


LRRC26 is a functional BK channel auxiliary γ subunit in arterial smooth muscle cells.

Evanson KW, Bannister JP, Leo MD, Jaggar JH.

Circ Res. 2014 Aug 1;115(4):423-31. doi: 10.1161/CIRCRESAHA.115.303407. Epub 2014 Jun 6.


The role of the large-conductance voltage-dependent and calcium-activated potassium (BK(Ca)) channels in the regulation of rat ductus arteriosus tone.

Sun F, Hayama E, Katsube Y, Matsuoka R, Nakanishi T.

Heart Vessels. 2010 Nov;25(6):556-64. doi: 10.1007/s00380-010-0008-1. Epub 2010 Oct 9.


BK channel activation by tungstate requires the β1 subunit extracellular loop residues essential to modulate voltage sensor function and channel gating.

Fernández-Mariño AI, Valverde MA, Fernández-Fernández JM.

Pflugers Arch. 2014 Jul;466(7):1365-75. doi: 10.1007/s00424-013-1379-9. Epub 2013 Oct 26.


Requirement for functional BK channels in maintaining oscillation in venomotor tone revealed by species differences in expression of the β1 accessory subunits.

Xu H, Kandlikar SS, Westcott EB, Fink GD, Galligan JJ.

J Cardiovasc Pharmacol. 2012 Jan;59(1):29-36. doi: 10.1097/FJC.0b013e318233614c.


The vasodilator 17,18-epoxyeicosatetraenoic acid targets the pore-forming BK alpha channel subunit in rodents.

Hercule HC, Salanova B, Essin K, Honeck H, Falck JR, Sausbier M, Ruth P, Schunck WH, Luft FC, Gollasch M.

Exp Physiol. 2007 Nov;92(6):1067-76. Epub 2007 Aug 3.


Large-conductance Ca2+-activated K+ channel beta1-subunit knockout mice are not hypertensive.

Xu H, Garver H, Galligan JJ, Fink GD.

Am J Physiol Heart Circ Physiol. 2011 Feb;300(2):H476-85. doi: 10.1152/ajpheart.00975.2010. Epub 2010 Dec 3.

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