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Items: 1 to 20 of 206

1.

Structural and functional consequences of cardiac troponin C L57Q and I61Q Ca(2+)-desensitizing variants.

Wang D, McCully ME, Luo Z, McMichael J, Tu AY, Daggett V, Regnier M.

Arch Biochem Biophys. 2013 Jul 1;535(1):68-75. doi: 10.1016/j.abb.2013.02.006. Epub 2013 Feb 28.

2.

Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation.

Wang D, Robertson IM, Li MX, McCully ME, Crane ML, Luo Z, Tu AY, Daggett V, Sykes BD, Regnier M.

Biochemistry. 2012 Jun 5;51(22):4473-87. Epub 2012 May 23.

3.

Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C.

Li MX, Spyracopoulos L, Sykes BD.

Biochemistry. 1999 Jun 29;38(26):8289-98.

PMID:
10387074
4.

Defining the binding site of levosimendan and its analogues in a regulatory cardiac troponin C-troponin I complex.

Robertson IM, Baryshnikova OK, Li MX, Sykes BD.

Biochemistry. 2008 Jul 15;47(28):7485-95. doi: 10.1021/bi800438k. Epub 2008 Jun 21.

5.

Molecular dynamics simulations of the cardiac troponin complex performed with FRET distances as restraints.

Jayasundar JJ, Xing J, Robinson JM, Cheung HC, Dong WJ.

PLoS One. 2014 Feb 18;9(2):e87135. doi: 10.1371/journal.pone.0087135. eCollection 2014.

6.

The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C.

Hwang PM, Cai F, Pineda-Sanabria SE, Corson DC, Sykes BD.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14412-7. doi: 10.1073/pnas.1410775111. Epub 2014 Sep 22.

7.

Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle.

Kreutziger KL, Piroddi N, McMichael JT, Tesi C, Poggesi C, Regnier M.

J Mol Cell Cardiol. 2011 Jan;50(1):165-74. doi: 10.1016/j.yjmcc.2010.10.025. Epub 2010 Oct 28.

8.

A structural and functional perspective into the mechanism of Ca2+-sensitizers that target the cardiac troponin complex.

Robertson IM, Sun YB, Li MX, Sykes BD.

J Mol Cell Cardiol. 2010 Dec;49(6):1031-41. doi: 10.1016/j.yjmcc.2010.08.019. Epub 2010 Aug 27.

9.

Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca2+-sensitizing mutations.

Stevens CM, Rayani K, Singh G, Lotfalisalmasi B, Tieleman DP, Tibbits GF.

J Biol Chem. 2017 Jul 14;292(28):11915-11926. doi: 10.1074/jbc.M116.770776. Epub 2017 May 22.

PMID:
28533433
10.

Solution structures of the C-terminal domain of cardiac troponin C free and bound to the N-terminal domain of cardiac troponin I.

Gasmi-Seabrook GM, Howarth JW, Finley N, Abusamhadneh E, Gaponenko V, Brito RM, Solaro RJ, Rosevear PR.

Biochemistry. 1999 Jun 29;38(26):8313-22. Erratum in: Biochemistry. 1999 Oct 26;38(43):14432.

PMID:
10387077
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15.

Ca(2+) induces an extended conformation of the inhibitory region of troponin I in cardiac muscle troponin.

Dong WJ, Xing J, Robinson JM, Cheung HC.

J Mol Biol. 2001 Nov 16;314(1):51-61.

PMID:
11724531
16.

Computational studies of the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics.

Cheng Y, Lindert S, Kekenes-Huskey P, Rao VS, Solaro RJ, Rosevear PR, Amaro R, McCulloch AD, McCammon JA, Regnier M.

Biophys J. 2014 Oct 7;107(7):1675-85. doi: 10.1016/j.bpj.2014.08.008.

17.

Effects of protein kinase A phosphorylation on signaling between cardiac troponin I and the N-terminal domain of cardiac troponin C.

Chandra M, Dong WJ, Pan BS, Cheung HC, Solaro RJ.

Biochemistry. 1997 Oct 28;36(43):13305-11.

PMID:
9341222
18.

Conformation of the regulatory domain of cardiac muscle troponin C in its complex with cardiac troponin I.

Dong WJ, Xing J, Villain M, Hellinger M, Robinson JM, Chandra M, Solaro RJ, Umeda PK, Cheung HC.

J Biol Chem. 1999 Oct 29;274(44):31382-90.

20.

Phosphorylation and mutation of human cardiac troponin I deferentially destabilize the interaction of the functional regions of troponin I with troponin C.

Li MX, Wang X, Lindhout DA, Buscemi N, Van Eyk JE, Sykes BD.

Biochemistry. 2003 Dec 16;42(49):14460-8.

PMID:
14661957

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