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Kinetic modeling-based detection of genetic signatures that provide chemoresistance via the E2F1-p73/DNp73-miR-205 network.

Vera J, Schmitz U, Lai X, Engelmann D, Khan FM, Wolkenhauer O, Pützer BM.

Cancer Res. 2013 Jun 15;73(12):3511-24. doi: 10.1158/0008-5472.CAN-12-4095. Epub 2013 Feb 27.


E2F1 confers anticancer drug resistance by targeting ABC transporter family members and Bcl-2 via the p73/DNp73-miR-205 circuitry.

Alla V, Kowtharapu BS, Engelmann D, Emmrich S, Schmitz U, Steder M, Pützer BM.

Cell Cycle. 2012 Aug 15;11(16):3067-78. doi: 10.4161/cc.21476. Epub 2012 Aug 8.


Overexpression of E2F1 in human gastric carcinoma is involved in anti-cancer drug resistance.

Yan LH, Wei WY, Cao WL, Zhang XS, Xie YB, Xiao Q.

BMC Cancer. 2014 Dec 3;14:904. doi: 10.1186/1471-2407-14-904.


NEDDylation controls the target specificity of E2F1 and apoptosis induction.

Aoki I, Higuchi M, Gotoh Y.

Oncogene. 2013 Aug 22;32(34):3954-64. doi: 10.1038/onc.2012.428. Epub 2012 Sep 24.


p73 and IGF1R Regulate Emergence of Aggressive Cancer Stem-like Features via miR-885-5p Control.

Meier C, Hardtstock P, Joost S, Alla V, Pützer BM.

Cancer Res. 2016 Jan 15;76(2):197-205. doi: 10.1158/0008-5472.CAN-15-1228. Epub 2015 Nov 10.


Deregulated expression of E2F1 promotes proteolytic degradation of tumor suppressor p73 and inhibits its transcriptional activity.

Ozaki T, Okoshi R, Ono S, Kubo N, Nakagawara A.

Biochem Biophys Res Commun. 2009 Sep 11;387(1):143-8. doi: 10.1016/j.bbrc.2009.06.141. Epub 2009 Jul 1.


MiR-136 targets E2F1 to reverse cisplatin chemosensitivity in glioma cells.

Chen W, Yang Y, Chen B, Lu P, Zhan L, Yu Q, Cao K, Li Q.

J Neurooncol. 2014 Oct;120(1):43-53. doi: 10.1007/s11060-014-1535-x. Epub 2014 Aug 20.


MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.

Yang SZ, Lin FT, Lin WC.

EMBO Rep. 2008 Sep;9(9):907-15. doi: 10.1038/embor.2008.128. Epub 2008 Jul 25.


p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor.

Testoni B, Schinzari V, Guerrieri F, Gerbal-Chaloin S, Blandino G, Levrero M.

Oncogene. 2011 Jun 9;30(23):2670-8. doi: 10.1038/onc.2010.635. Epub 2011 Mar 14.


P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism.

Al-Bahlani S, Fraser M, Wong AY, Sayan BS, Bergeron R, Melino G, Tsang BK.

Oncogene. 2011 Oct 13;30(41):4219-30. doi: 10.1038/onc.2011.134. Epub 2011 Apr 25.


The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network.

Boominathan L.

Cancer Metastasis Rev. 2010 Dec;29(4):613-39. doi: 10.1007/s10555-010-9257-9. Review.


Yin Yang 1 induces transcriptional activity of p73 through cooperation with E2F1.

Wu S, Murai S, Kataoka K, Miyagishi M.

Biochem Biophys Res Commun. 2008 Jan 4;365(1):75-81. Epub 2007 Nov 1.


The tumor suppressor maspin mediates E2F1-induced sensitivity of cancer cells to chemotherapy.

Ben Shachar B, Feldstein O, Hacohen D, Ginsberg D.

Mol Cancer Res. 2010 Mar;8(3):363-72. doi: 10.1158/1541-7786.MCR-09-0137. Epub 2010 Mar 2.


Variation in transcriptional regulation of cyclin dependent kinase inhibitor p21waf1/cip1 among human bronchogenic carcinomas.

Harr MW, Graves TG, Crawford EL, Warner KA, Reed CA, Willey JC.

Mol Cancer. 2005 Jul 13;4:23.


Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1.

Ray RM, Bhattacharya S, Johnson LR.

Apoptosis. 2011 Jan;16(1):35-44. doi: 10.1007/s10495-010-0538-0.


Suppression of acetylpolyamine oxidase by selected AP-1 members regulates DNp73 abundance: mechanistic insights for overcoming DNp73-mediated resistance to chemotherapeutic drugs.

Bunjobpol W, Dulloo I, Igarashi K, Concin N, Matsuo K, Sabapathy K.

Cell Death Differ. 2014 Aug;21(8):1240-9. doi: 10.1038/cdd.2014.41. Epub 2014 Apr 11.


Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1.

Ambrosini G, Sambol EB, Carvajal D, Vassilev LT, Singer S, Schwartz GK.

Oncogene. 2007 May 24;26(24):3473-81. Epub 2006 Dec 4.


E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer.

Petrocca F, Visone R, Onelli MR, Shah MH, Nicoloso MS, de Martino I, Iliopoulos D, Pilozzi E, Liu CG, Negrini M, Cavazzini L, Volinia S, Alder H, Ruco LP, Baldassarre G, Croce CM, Vecchione A.

Cancer Cell. 2008 Mar;13(3):272-86. doi: 10.1016/j.ccr.2008.02.013.


Mechanisms, function and clinical applications of DNp73.

Di C, Yang L, Zhang H, Ma X, Zhang X, Sun C, Li H, Xu S, An L, Li X, Bai Z.

Cell Cycle. 2013 Jun 15;12(12):1861-7. doi: 10.4161/cc.24967. Epub 2013 Jun 13. Review.

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