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Items: 1 to 20 of 119

1.

GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.

Atwood SX, Li M, Lee A, Tang JY, Oro AE.

Nature. 2013 Feb 28;494(7438):484-8. doi: 10.1038/nature11889.

2.

aPKC ι/λ: a potential target for the therapy of Hh-dependent and Smo-inhibitor-resistant advanced BCC.

Lv X, Fu L, Zhao Y.

Acta Biochim Biophys Sin (Shanghai). 2013 Jul;45(7):610-1. doi: 10.1093/abbs/gmt053. Epub 2013 May 17. No abstract available.

PMID:
23685738
3.

DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.

Gruber W, Hutzinger M, Elmer DP, Parigger T, Sternberg C, Cegielkowski L, Zaja M, Leban J, Michel S, Hamm S, Vitt D, Aberger F.

Oncotarget. 2016 Feb 9;7(6):7134-48. doi: 10.18632/oncotarget.6910.

4.

Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance.

Gruber W, Peer E, Elmer DP, Sternberg C, Tesanovic S, Del Burgo P, Coni S, Canettieri G, Neureiter D, Bartz R, Kohlhof H, Vitt D, Aberger F.

Int J Cancer. 2018 Mar 1;142(5):968-975. doi: 10.1002/ijc.31117. Epub 2017 Nov 6.

5.

Protein kinase A activation inhibits oncogenic Sonic hedgehog signalling and suppresses basal cell carcinoma of the skin.

Makinodan E, Marneros AG.

Exp Dermatol. 2012 Nov;21(11):847-52. doi: 10.1111/exd.12016.

PMID:
23163650
6.

Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila.

Jiang K, Liu Y, Fan J, Epperly G, Gao T, Jiang J, Jia J.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4842-50. doi: 10.1073/pnas.1417147111. Epub 2014 Oct 27.

7.

The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury.

Grzelak CA, Martelotto LG, Sigglekow ND, Patkunanathan B, Ajami K, Calabro SR, Dwyer BJ, Tirnitz-Parker JE, Watkins DN, Warner FJ, Shackel NA, McCaughan GW.

J Hepatol. 2014 Jan;60(1):143-51. doi: 10.1016/j.jhep.2013.08.012. Epub 2013 Aug 23.

PMID:
23978713
8.

Imiquimod directly inhibits Hedgehog signalling by stimulating adenosine receptor/protein kinase A-mediated GLI phosphorylation.

Wolff F, Loipetzberger A, Gruber W, Esterbauer H, Aberger F, Frischauf AM.

Oncogene. 2013 Dec 12;32(50):5574-81. doi: 10.1038/onc.2013.343. Epub 2013 Sep 2.

9.

Pyrvinium attenuates Hedgehog signaling downstream of smoothened.

Li B, Fei DL, Flaveny CA, Dahmane N, Baubet V, Wang Z, Bai F, Pei XH, Rodriguez-Blanco J, Hang B, Orton D, Han L, Wang B, Capobianco AJ, Lee E, Robbins DJ.

Cancer Res. 2014 Sep 1;74(17):4811-21. doi: 10.1158/0008-5472.CAN-14-0317. Epub 2014 Jul 3.

10.

Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.

You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM.

J Thorac Cardiovasc Surg. 2014 Jan;147(1):508-16. doi: 10.1016/j.jtcvs.2013.08.035. Epub 2013 Oct 4.

11.

The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.

Long J, Li B, Rodriguez-Blanco J, Pastori C, Volmar CH, Wahlestedt C, Capobianco A, Bai F, Pei XH, Ayad NG, Robbins DJ.

J Biol Chem. 2014 Dec 19;289(51):35494-502. doi: 10.1074/jbc.M114.595348. Epub 2014 Oct 29.

12.

Gli as a novel therapeutic target in malignant pleural mesothelioma.

Li H, Lui N, Cheng T, Tseng HH, Yue D, Giroux-Leprieur E, Do HT, Sheng Q, Jin JQ, Luh TW, Jablons DM, He B.

PLoS One. 2013;8(3):e57346. doi: 10.1371/journal.pone.0057346. Epub 2013 Mar 6.

13.

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.

Mazumdar T, DeVecchio J, Agyeman A, Shi T, Houghton JA.

Oncotarget. 2011 Aug;2(8):638-45.

14.

Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2.

Yang C, Chen W, Chen Y, Jiang J.

Cell Res. 2012 Nov;22(11):1593-604. doi: 10.1038/cr.2012.134. Epub 2012 Sep 18.

15.

Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.

Cohen JR, Resnick DZ, Niewiadomski P, Dong H, Liau LM, Waschek JA.

BMC Cancer. 2010 Dec 9;10:676. doi: 10.1186/1471-2407-10-676.

16.

Smoothened variants explain the majority of drug resistance in basal cell carcinoma.

Atwood SX, Sarin KY, Whitson RJ, Li JR, Kim G, Rezaee M, Ally MS, Kim J, Yao C, Chang AL, Oro AE, Tang JY.

Cancer Cell. 2015 Mar 9;27(3):342-53. doi: 10.1016/j.ccell.2015.02.002.

17.
18.

Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells.

D'Amato C, Rosa R, Marciano R, D'Amato V, Formisano L, Nappi L, Raimondo L, Di Mauro C, Servetto A, Fulciniti F, Cipolletta A, Bianco C, Ciardiello F, Veneziani BM, De Placido S, Bianco R.

Br J Cancer. 2014 Sep 9;111(6):1168-79. doi: 10.1038/bjc.2014.421. Epub 2014 Aug 5.

19.

Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells.

Eberl M, Klingler S, Mangelberger D, Loipetzberger A, Damhofer H, Zoidl K, Schnidar H, Hache H, Bauer HC, Solca F, Hauser-Kronberger C, Ermilov AN, Verhaegen ME, Bichakjian CK, Dlugosz AA, Nietfeld W, Sibilia M, Lehrach H, Wierling C, Aberger F.

EMBO Mol Med. 2012 Mar;4(3):218-33. doi: 10.1002/emmm.201100201. Epub 2012 Feb 1.

20.

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma.

Regl G, Neill GW, Eichberger T, Kasper M, Ikram MS, Koller J, Hintner H, Quinn AG, Frischauf AM, Aberger F.

Oncogene. 2002 Aug 15;21(36):5529-39.

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