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Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.

Ferrari M, Dibitetto D, De Gregorio G, Eapen VV, Rawal CC, Lazzaro F, Tsabar M, Marini F, Haber JE, Pellicioli A.

PLoS Genet. 2015 Jan 8;11(1):e1004928. doi: 10.1371/journal.pgen.1004928. eCollection 2015 Jan.


Coincident resection at both ends of random, γ-induced double-strand breaks requires MRX (MRN), Sae2 (Ctp1), and Mre11-nuclease.

Westmoreland JW, Resnick MA.

PLoS Genet. 2013 Mar;9(3):e1003420. doi: 10.1371/journal.pgen.1003420. Epub 2013 Mar 28.


Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage.

Foster SS, Balestrini A, Petrini JH.

Mol Cell Biol. 2011 Nov;31(21):4379-89. doi: 10.1128/MCB.05854-11. Epub 2011 Aug 29.


Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling.

Chen H, Donnianni RA, Handa N, Deng SK, Oh J, Timashev LA, Kowalczykowski SC, Symington LS.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1880-7. doi: 10.1073/pnas.1503331112. Epub 2015 Mar 23.


Yeast xrs2 binds DNA and helps target rad50 and mre11 to DNA ends.

Trujillo KM, Roh DH, Chen L, Van Komen S, Tomkinson A, Sung P.

J Biol Chem. 2003 Dec 5;278(49):48957-64. Epub 2003 Sep 30.


Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes.

Chen L, Trujillo K, Ramos W, Sung P, Tomkinson AE.

Mol Cell. 2001 Nov;8(5):1105-15.


S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex.

Chen YJ, Chuang YC, Chuang CN, Cheng YH, Chang CR, Leng CH, Wang TF.

Nucleic Acids Res. 2016 Mar 18;44(5):2199-213. doi: 10.1093/nar/gkv1523. Epub 2016 Jan 6.


Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex.

Lengsfeld BM, Rattray AJ, Bhaskara V, Ghirlando R, Paull TT.

Mol Cell. 2007 Nov 30;28(4):638-51.


Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

Langerak P, Mejia-Ramirez E, Limbo O, Russell P.

PLoS Genet. 2011 Sep;7(9):e1002271. doi: 10.1371/journal.pgen.1002271. Epub 2011 Sep 8.


Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks.

Shim EY, Chung WH, Nicolette ML, Zhang Y, Davis M, Zhu Z, Paull TT, Ira G, Lee SE.

EMBO J. 2010 Oct 6;29(19):3370-80. doi: 10.1038/emboj.2010.219. Epub 2010 Sep 10.


Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks.

Cannavo E, Cejka P.

Nature. 2014 Oct 2;514(7520):122-5. doi: 10.1038/nature13771. Epub 2014 Sep 17.


The Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex promotes trinucleotide repeat expansions independently of homologous recombination.

Ye Y, Kirkham-McCarthy L, Lahue RS.

DNA Repair (Amst). 2016 Jul;43:1-8. doi: 10.1016/j.dnarep.2016.04.012. Epub 2016 May 2.


Relationship of DNA degradation by Saccharomyces cerevisiae exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection.

Cannavo E, Cejka P, Kowalczykowski SC.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):E1661-8. doi: 10.1073/pnas.1305166110. Epub 2013 Apr 15.


Synthetic viability genomic screening defines Sae2 function in DNA repair.

Puddu F, Oelschlaegel T, Guerini I, Geisler NJ, Niu H, Herzog M, Salguero I, Ochoa-Montaño B, Viré E, Sung P, Adams DJ, Keane TM, Jackson SP.

EMBO J. 2015 Jun 3;34(11):1509-22. doi: 10.15252/embj.201590973. Epub 2015 Apr 21.


The Mre11/Rad50/Xrs2 complex and non-homologous end-joining of incompatible ends in S. cerevisiae.

Zhang X, Paull TT.

DNA Repair (Amst). 2005 Nov 21;4(11):1281-94. Epub 2005 Jul 25.


Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing.

Mimitou EP, Symington LS.

Nature. 2008 Oct 9;455(7214):770-4. doi: 10.1038/nature07312. Epub 2008 Sep 21.

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