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Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis.

Bleicken S, Wagner C, García-Sáez AJ.

Biophys J. 2013 Jan 22;104(2):421-31. doi: 10.1016/j.bpj.2012.12.010.


Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax.

Lovell JF, Billen LP, Bindner S, Shamas-Din A, Fradin C, Leber B, Andrews DW.

Cell. 2008 Dec 12;135(6):1074-84. doi: 10.1016/j.cell.2008.11.010.


cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities.

Bleicken S, Hofhaus G, Ugarte-Uribe B, Schröder R, García-Sáez AJ.

Cell Death Dis. 2016 Feb 25;7:e2121. doi: 10.1038/cddis.2016.34.


The cytosolic domain of Bcl-2 forms small pores in model mitochondrial outer membrane after acidic pH-induced membrane association.

Peng J, Lapolla SM, Zhang Z, Lin J.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Feb;26(1):130-7.


Bcl-XL inhibits membrane permeabilization by competing with Bax.

Billen LP, Kokoski CL, Lovell JF, Leber B, Andrews DW.

PLoS Biol. 2008 Jun 10;6(6):e147. doi: 10.1371/journal.pbio.0060147.


BAX insertion, oligomerization, and outer membrane permeabilization in brain mitochondria: role of permeability transition and SH-redox regulation.

Brustovetsky T, Li T, Yang Y, Zhang JT, Antonsson B, Brustovetsky N.

Biochim Biophys Acta. 2010 Nov;1797(11):1795-806. doi: 10.1016/j.bbabio.2010.07.006. Epub 2010 Jul 23.


Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations.

Basañez G, Nechushtan A, Drozhinin O, Chanturiya A, Choe E, Tutt S, Wood KA, Hsu Y, Zimmerberg J, Youle RJ.

Proc Natl Acad Sci U S A. 1999 May 11;96(10):5492-7.


Active fragments from pro- and antiapoptotic BCL-2 proteins have distinct membrane behavior reflecting their functional divergence.

Guillemin Y, Lopez J, Gimenez D, Fuertes G, Valero JG, Blum L, Gonzalo P, Salgado J, Girard-Egrot A, Aouacheria A.

PLoS One. 2010 Feb 5;5(2):e9066. doi: 10.1371/journal.pone.0009066.


The multidomain proapoptotic molecules Bax and Bak are directly activated by heat.

Pagliari LJ, Kuwana T, Bonzon C, Newmeyer DD, Tu S, Beere HM, Green DR.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17975-80. Epub 2005 Dec 5.


Integration and oligomerization of Bax protein in lipid bilayers characterized by single molecule fluorescence study.

Luo L, Yang J, Liu D.

J Biol Chem. 2014 Nov 14;289(46):31708-18. doi: 10.1074/jbc.M114.583393. Epub 2014 Oct 6.


After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.

Ding J, Mooers BH, Zhang Z, Kale J, Falcone D, McNichol J, Huang B, Zhang XC, Xing C, Andrews DW, Lin J.

J Biol Chem. 2014 Apr 25;289(17):11873-96. doi: 10.1074/jbc.M114.552562. Epub 2014 Mar 10.


Conformational changes in BAK, a pore-forming proapoptotic Bcl-2 family member, upon membrane insertion and direct evidence for the existence of BH3-BH3 contact interface in BAK homo-oligomers.

Oh KJ, Singh P, Lee K, Foss K, Lee S, Park M, Lee S, Aluvila S, Park M, Singh P, Kim RS, Symersky J, Walters DE.

J Biol Chem. 2010 Sep 10;285(37):28924-37. doi: 10.1074/jbc.M110.135293. Epub 2010 Jul 6.


The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release.

Ott M, Norberg E, Walter KM, Schreiner P, Kemper C, Rapaport D, Zhivotovsky B, Orrenius S.

J Biol Chem. 2007 Sep 21;282(38):27633-9. Epub 2007 Jul 16.


Lipidic pore formation by the concerted action of proapoptotic BAX and tBID.

Terrones O, Antonsson B, Yamaguchi H, Wang HG, Liu J, Lee RM, Herrmann A, Basañez G.

J Biol Chem. 2004 Jul 16;279(29):30081-91. Epub 2004 May 11.


Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane.

Ganesan V, Perera MN, Colombini D, Datskovskiy D, Chadha K, Colombini M.

Apoptosis. 2010 May;15(5):553-62. doi: 10.1007/s10495-009-0449-0.


Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid.

Shamas-Din A, Satsoura D, Khan O, Zhu W, Leber B, Fradin C, Andrews DW.

Cell Death Dis. 2014 Jun 5;5:e1277. doi: 10.1038/cddis.2014.234.


CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation.

Liu Y, Clegg HV, Leslie PL, Di J, Tollini LA, He Y, Kim TH, Jin A, Graves LM, Zheng J, Zhang Y.

Cell Death Differ. 2015 Jun;22(6):1035-46. doi: 10.1038/cdd.2014.194. Epub 2014 Dec 5.


Bid induces cytochrome c-impermeable Bax channels in liposomes.

Roucou X, Rostovtseva T, Montessuit S, Martinou JC, Antonsson B.

Biochem J. 2002 May 1;363(Pt 3):547-52.

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