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Items: 1 to 20 of 93


Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilization.

Nahm M, Lee MJ, Parkinson W, Lee M, Kim H, Kim YJ, Kim S, Cho YS, Min BM, Bae YC, Broadie K, Lee S.

Neuron. 2013 Feb 20;77(4):680-95. doi: 10.1016/j.neuron.2012.12.015.


Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules.

Wang X, Shaw WR, Tsang HT, Reid E, O'Kane CJ.

Nat Neurosci. 2007 Feb;10(2):177-85. Epub 2007 Jan 14.


Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling.

Renvoisé B, Stadler J, Singh R, Bakowska JC, Blackstone C.

Hum Mol Genet. 2012 Aug 15;21(16):3604-18. doi: 10.1093/hmg/dds191. Epub 2012 May 22.


Is instability good for the brain?

Carrillo RA, Menon K, Zinn K.

Neuron. 2013 Feb 20;77(4):599-601. doi: 10.1016/j.neuron.2013.02.002.


The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling.

Tsang HT, Edwards TL, Wang X, Connell JW, Davies RJ, Durrington HJ, O'Kane CJ, Luzio JP, Reid E.

Hum Mol Genet. 2009 Oct 15;18(20):3805-21. doi: 10.1093/hmg/ddp324. Epub 2009 Jul 20.


The Troyer syndrome (SPG20) protein spartin interacts with Eps15.

Bakowska JC, Jenkins R, Pendleton J, Blackstone C.

Biochem Biophys Res Commun. 2005 Sep 9;334(4):1042-8.


The hereditary spastic paraplegia protein spartin localises to mitochondria.

Lu J, Rashid F, Byrne PC.

J Neurochem. 2006 Sep;98(6):1908-19.


Troyer syndrome protein spartin is mono-ubiquitinated and functions in EGF receptor trafficking.

Bakowska JC, Jupille H, Fatheddin P, Puertollano R, Blackstone C.

Mol Biol Cell. 2007 May;18(5):1683-92. Epub 2007 Mar 1.


The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

Trotta N, Orso G, Rossetto MG, Daga A, Broadie K.

Curr Biol. 2004 Jul 13;14(13):1135-47.


Lack of spartin protein in Troyer syndrome: a loss-of-function disease mechanism?

Bakowska JC, Wang H, Xin B, Sumner CJ, Blackstone C.

Arch Neurol. 2008 Apr;65(4):520-4. doi: 10.1001/archneur.65.4.520.


Retrograde BMP signaling at the synapse: a permissive signal for synapse maturation and activity-dependent plasticity.

Berke B, Wittnam J, McNeill E, Van Vactor DL, Keshishian H.

J Neurosci. 2013 Nov 6;33(45):17937-50. doi: 10.1523/JNEUROSCI.6075-11.2013.


Drosophila S6 Kinase like inhibits neuromuscular junction growth by downregulating the BMP receptor thickveins.

Zhao G, Wu Y, Du L, Li W, Xiong Y, Yao A, Wang Q, Zhang YQ.

PLoS Genet. 2015 Mar 6;11(3):e1004984. doi: 10.1371/journal.pgen.1004984. eCollection 2015 Mar.


Angelman Syndrome Protein Ube3a Regulates Synaptic Growth and Endocytosis by Inhibiting BMP Signaling in Drosophila.

Li W, Yao A, Zhi H, Kaur K, Zhu YC, Jia M, Zhao H, Wang Q, Jin S, Zhao G, Xiong ZQ, Zhang YQ.

PLoS Genet. 2016 May 27;12(5):e1006062. doi: 10.1371/journal.pgen.1006062. eCollection 2016 May.


Endogenous spartin, mutated in hereditary spastic paraplegia, has a complex subcellular localization suggesting diverse roles in neurons.

Robay D, Patel H, Simpson MA, Brown NA, Crosby AH.

Exp Cell Res. 2006 Sep 10;312(15):2764-77. Epub 2006 May 13.


Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function.

Zhang YQ, Bailey AM, Matthies HJ, Renden RB, Smith MA, Speese SD, Rubin GM, Broadie K.

Cell. 2001 Nov 30;107(5):591-603.


Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia.

Zempel H, Mandelkow EM.

Mol Neurodegener. 2015 Dec 21;10:68. doi: 10.1186/s13024-015-0064-1. Review.


The Rap activator Gef26 regulates synaptic growth and neuronal survival via inhibition of BMP signaling.

Heo K, Nahm M, Lee MJ, Kim YE, Ki CS, Kim SH, Lee S.

Mol Brain. 2017 Dec 28;10(1):62. doi: 10.1186/s13041-017-0342-7.


BMP signaling and microtubule organization regulate synaptic strength.

Ball RW, Peled ES, Guerrero G, Isacoff EY.

Neuroscience. 2015 Apr 16;291:155-66. doi: 10.1016/j.neuroscience.2015.01.069. Epub 2015 Feb 11.


Different expression levels of spartin cause broad spectrum of cellular consequences in human neuroblastoma cells.

Milewska M, Byrne PC.

Cell Biol Int. 2015 Sep;39(9):1007-15. doi: 10.1002/cbin.10472. Epub 2015 May 8.


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