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Items: 1 to 20 of 101

1.

Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation.

Wang B, Song Y, Luo M, Chen Q, Ma J, Huang H, Ju J.

Org Lett. 2013 Mar 15;15(6):1278-81. doi: 10.1021/ol400224n. Epub 2013 Feb 25.

PMID:
23438151
2.

Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.

Seo JW, Ma M, Kwong T, Ju J, Lim SK, Jiang H, Lohman JR, Yang C, Cleveland J, Zazopoulos E, Farnet CM, Shen B.

Biochemistry. 2014 Dec 16;53(49):7854-65. doi: 10.1021/bi501396v. Epub 2014 Dec 1.

3.

iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.

Lim SK, Ju J, Zazopoulos E, Jiang H, Seo JW, Chen Y, Feng Z, Rajski SR, Farnet CM, Shen B.

J Biol Chem. 2009 Oct 23;284(43):29746-56. doi: 10.1074/jbc.M109.046805. Epub 2009 Sep 2.

4.

5-Hydroxy-9-methylstreptimidone, a new glutarimide from a Streptomyces sp. HIL Y-9065403.

Chatterjee S, Vijayakumar EK, Chatterjee S, Blumbach J, Ganguli BN.

J Antibiot (Tokyo). 1995 Mar;48(3):271-3. No abstract available.

5.

Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins.

Zhang B, Yang D, Yan Y, Pan G, Xiang W, Shen B.

Appl Microbiol Biotechnol. 2016 Mar;100(5):2267-77. doi: 10.1007/s00253-015-7119-7. Epub 2015 Nov 10.

6.

Elucidation of the biosynthetic gene cluster and the post-PKS modification mechanism for fostriecin in Streptomyces pulveraceus.

Kong R, Liu X, Su C, Ma C, Qiu R, Tang L.

Chem Biol. 2013 Jan 24;20(1):45-54. doi: 10.1016/j.chembiol.2012.10.018.

7.

Unveiling the post-PKS redox tailoring steps in biosynthesis of the type II polyketide antitumor antibiotic xantholipin.

Zhang W, Wang L, Kong L, Wang T, Chu Y, Deng Z, You D.

Chem Biol. 2012 Mar 23;19(3):422-32. doi: 10.1016/j.chembiol.2012.01.016.

8.

Enzymatic polyketide chain branching to give substituted lactone, lactam, and glutarimide heterocycles.

Heine D, Bretschneider T, Sundaram S, Hertweck C.

Angew Chem Int Ed Engl. 2014 Oct 20;53(43):11645-9. doi: 10.1002/anie.201407282. Epub 2014 Sep 11.

PMID:
25214315
9.

Antiviral and interferon-inducing activity of a new glutarimide antibiotic, 9-methylstreptimidone.

Saito N, Suzuki F, Sasaki K, Ishida N.

Antimicrob Agents Chemother. 1976 Jul;10(1):14-9.

10.

Biosynthesis of the structurally unique polycyclopropanated polyketide-nucleoside hybrid jawsamycin (FR-900848).

Hiratsuka T, Suzuki H, Kariya R, Seo T, Minami A, Oikawa H.

Angew Chem Int Ed Engl. 2014 May 19;53(21):5423-6. doi: 10.1002/anie.201402623. Epub 2014 Apr 23.

PMID:
24756819
11.

Biosynthesis of the Novel Macrolide Antibiotic Anthracimycin.

Alt S, Wilkinson B.

ACS Chem Biol. 2015 Nov 20;10(11):2468-79. doi: 10.1021/acschembio.5b00525. Epub 2015 Sep 8.

12.

A trans-acting ketoreductase in biosynthesis of a symmetric polyketide dimer SIA7248.

Zou Y, Yin H, Kong D, Deng Z, Lin S.

Chembiochem. 2013 Apr 15;14(6):679-83. doi: 10.1002/cbic.201300068. Epub 2013 Mar 15.

PMID:
23505159
14.

Identification of the biosynthetic gene cluster and regulatory cascade for the synergistic antibacterial antibiotics griseoviridin and viridogrisein in Streptomyces griseoviridis.

Xie Y, Wang B, Liu J, Zhou J, Ma J, Huang H, Ju J.

Chembiochem. 2012 Dec 21;13(18):2745-57. doi: 10.1002/cbic.201200584. Epub 2012 Nov 19.

PMID:
23161816
15.

Cloning, heterologous expression, and characterization of the gene cluster required for gougerotin biosynthesis.

Niu G, Li L, Wei J, Tan H.

Chem Biol. 2013 Jan 24;20(1):34-44. doi: 10.1016/j.chembiol.2012.10.017.

16.

Molecular Genetic Characterization of an Anthrabenzoxocinones Gene Cluster in Streptomyces Sp. FJS31-2 for the Biosynthesis of BE-24566B and Zunyimycin Ale.

Lü Y, Yue C, Shao M, Qian S, Liu N, Bao Y, Wang M, Liu M, Li X, Wang Y, Huang Y.

Molecules. 2016 May 30;21(6). pii: E711. doi: 10.3390/molecules21060711.

17.

Biosynthesis of ebelactone A: isotopic tracer, advanced precursor and genetic studies reveal a thioesterase-independent cyclization to give a polyketide β-lactone.

Wyatt MA, Ahilan Y, Argyropoulos P, Boddy CN, Magarvey NA, Harrison PH.

J Antibiot (Tokyo). 2013 Jul;66(7):421-30. doi: 10.1038/ja.2013.48. Epub 2013 Jun 26.

PMID:
23801186
18.

Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.

Brautaset T, Sekurova ON, Sletta H, Ellingsen TE, StrŁm AR, Valla S, Zotchev SB.

Chem Biol. 2000 Jun;7(6):395-403. Erratum in: Chem Biol 2000 Jul;7(7):R176.

19.

[Polyketide antibiotics produced by polyketide synthase in streptomyces--a review].

Chen M, Wang G, Dai S, Xie L, Li X.

Wei Sheng Wu Xue Bao. 2009 Dec;49(12):1555-63. Review. Chinese.

PMID:
20222438
20.

Biosynthesis of versipelostatin: identification of an enzyme-catalyzed [4+2]-cycloaddition required for macrocyclization of spirotetronate-containing polyketides.

Hashimoto T, Hashimoto J, Teruya K, Hirano T, Shin-ya K, Ikeda H, Liu HW, Nishiyama M, Kuzuyama T.

J Am Chem Soc. 2015 Jan 21;137(2):572-5. doi: 10.1021/ja510711x. Epub 2015 Jan 5.

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