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Role of IRAK-M in alcohol induced liver injury.

Wang Y, Hu Y, Chao C, Yuksel M, Colle I, Flavell RA, Ma Y, Yan H, Wen L.

PLoS One. 2013;8(2):e57085. doi: 10.1371/journal.pone.0057085. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/678de7ff-0a7e-4200-a8a2-bd739ff14eef.


IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses.

Lye E, Dhanji S, Calzascia T, Elford AR, Ohashi PS.

Eur J Immunol. 2008 Mar;38(3):870-6. doi: 10.1002/eji.200737429.


Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice.

Klimesova K, Kverka M, Zakostelska Z, Hudcovic T, Hrncir T, Stepankova R, Rossmann P, Ridl J, Kostovcik M, Mrazek J, Kopecny J, Kobayashi KS, Tlaskalova-Hogenova H.

Inflamm Bowel Dis. 2013 May;19(6):1266-77. doi: 10.1097/MIB.0b013e318281330a.


Interleukin-1 receptor-associated kinase 4 is essential for initial host control of Brucella abortus infection.

Oliveira FS, Carvalho NB, Brandão AP, Gomes MT, de Almeida LA, Oliveira SC.

Infect Immun. 2011 Nov;79(11):4688-95. doi: 10.1128/IAI.05289-11.


TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth.

Standiford TJ, Kuick R, Bhan U, Chen J, Newstead M, Keshamouni VG.

Oncogene. 2011 May 26;30(21):2475-84. doi: 10.1038/onc.2010.619.


Endogenous IRAK-M attenuates postinfarction remodeling through effects on macrophages and fibroblasts.

Chen W, Saxena A, Li N, Sun J, Gupta A, Lee DW, Tian Q, Dobaczewski M, Frangogiannis NG.

Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2598-608. doi: 10.1161/ATVBAHA.112.300310.


The role of Interleukin Receptor Associated Kinase (IRAK)-M in regulation of myofibroblast phenotype in vitro, and in an experimental model of non-reperfused myocardial infarction.

Saxena A, Shinde AV, Haque Z, Wu YJ, Chen W, Su Y, Frangogiannis NG.

J Mol Cell Cardiol. 2015 Dec;89(Pt B):223-31. doi: 10.1016/j.yjmcc.2015.11.001.


Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M.

Rothschild DE, Zhang Y, Diao N, Lee CK, Chen K, Caswell CC, Slade DJ, Helm RF, LeRoith T, Li L, Allen IC.

EBioMedicine. 2017 Feb;15:36-47. doi: 10.1016/j.ebiom.2016.11.039.


Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes.

Julian MW, Strange HR, Ballinger MN, Hotchkiss RS, Papenfuss TL, Crouser ED.

PLoS One. 2015 Jul 28;10(7):e0132921. doi: 10.1371/journal.pone.0132921.


Interleukin-1 receptor-associated kinase M-deficient mice demonstrate an improved host defense during Gram-negative pneumonia.

Hoogerwerf JJ, van der Windt GJ, Blok DC, Hoogendijk AJ, De Vos AF, van 't Veer C, Florquin S, Kobayashi KS, Flavell RA, van der Poll T.

Mol Med. 2012 Sep 25;18:1067-75. doi: 10.2119/molmed.2011.00450.


The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling.

Flannery S, Bowie AG.

Biochem Pharmacol. 2010 Dec 15;80(12):1981-91. doi: 10.1016/j.bcp.2010.06.020. Review.


Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients.

McDonald DR, Goldman F, Gomez-Duarte OD, Issekutz AC, Kumararatne DS, Doffinger R, Geha RS.

J Allergy Clin Immunol. 2010 Aug;126(2):332-7, 337.e1-2. doi: 10.1016/j.jaci.2010.05.013.


Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression.

Peng JH, Cui T, Huang F, Chen L, Zhao Y, Xu L, Xu LL, Feng Q, Hu YY.

J Pharmacol Exp Ther. 2013 Mar;344(3):646-54. doi: 10.1124/jpet.112.201137.


IRAK-M deficiency promotes the development of type 1 diabetes in NOD mice.

Tan Q, Majewska-Szczepanik M, Zhang X, Szczepanik M, Zhou Z, Wong FS, Wen L.

Diabetes. 2014 Aug;63(8):2761-75. doi: 10.2337/db13-1504.


The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88.

Hritz I, Mandrekar P, Velayudham A, Catalano D, Dolganiuc A, Kodys K, Kurt-Jones E, Szabo G.

Hepatology. 2008 Oct;48(4):1224-31. doi: 10.1002/hep.22470.


Critical role of IL-1 receptor-associated kinase-M in regulating chemokine-dependent deleterious inflammation in murine influenza pneumonia.

Seki M, Kohno S, Newstead MW, Zeng X, Bhan U, Lukacs NW, Kunkel SL, Standiford TJ.

J Immunol. 2010 Feb 1;184(3):1410-8. doi: 10.4049/jimmunol.0901709.


Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1.

Maitra U, Davis S, Reilly CM, Li L.

J Immunol. 2009 May 1;182(9):5763-9. doi: 10.4049/jimmunol.0900124.


IRAK-M modulates expression of IL-10 and cell surface markers CD80 and MHC II after bacterial re-stimulation of tolerized dendritic cells.

Cole TS, Zhang M, Standiford TJ, Newstead M, Luther J, Zhang J, Chen CC, Kao JY.

Immunol Lett. 2012 May 30;144(1-2):49-59. doi: 10.1016/j.imlet.2012.03.006.


IRAK-M expression limits dendritic cell activation and proinflammatory cytokine production in response to Helicobacter pylori.

Shiu J, Czinn SJ, Kobayashi KS, Sun Y, Blanchard TG.

PLoS One. 2013 Jun 11;8(6):e66914. doi: 10.1371/journal.pone.0066914.

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