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Items: 1 to 20 of 143

1.

Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus.

Liu Y, Qin K, Meng G, Zhang J, Zhou J, Zhao G, Luo M, Zheng X.

J Biol Chem. 2013 Apr 19;288(16):11013-23. doi: 10.1074/jbc.M112.392878. Epub 2013 Feb 22.

2.

A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, and viral replication.

Hatakeyama D, Shoji M, Yamayoshi S, Hirota T, Nagae M, Yanagisawa S, Nakano M, Ohmi N, Noda T, Kawaoka Y, Kuzuhara T.

J Biol Chem. 2014 Sep 5;289(36):24980-94. doi: 10.1074/jbc.M114.559708. Epub 2014 Jul 25.

3.
4.

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit.

Dias A, Bouvier D, Crépin T, McCarthy AA, Hart DJ, Baudin F, Cusack S, Ruigrok RW.

Nature. 2009 Apr 16;458(7240):914-8. doi: 10.1038/nature07745. Epub 2009 Feb 4.

PMID:
19194459
5.

The structural basis for cap binding by influenza virus polymerase subunit PB2.

Guilligay D, Tarendeau F, Resa-Infante P, Coloma R, Crepin T, Sehr P, Lewis J, Ruigrok RW, Ortin J, Hart DJ, Cusack S.

Nat Struct Mol Biol. 2008 May;15(5):500-6. doi: 10.1038/nsmb.1421. Epub 2008 May 4.

PMID:
18454157
6.

Role of the PB2 627 Domain in Influenza A Virus Polymerase Function.

Nilsson BE, Te Velthuis AJ, Fodor E.

J Virol. 2017 Mar 13;91(7). pii: e02467-16. doi: 10.1128/JVI.02467-16. Print 2017 Apr 1. Erratum in: J Virol. 2017 May 26;91(12 ):.

7.

Two mutations in the C-terminal domain of influenza virus RNA polymerase PB2 enhance transcription by enhancing cap-1 RNA binding activity.

Zhang S, Wang Q, Wang J, Mizumoto K, Toyoda T.

Biochim Biophys Acta. 2012 Jan;1819(1):78-83. doi: 10.1016/j.bbagrm.2011.11.006. Epub 2011 Nov 30.

PMID:
22146492
8.

Crystallization and X-ray crystallographic analysis of the cap-binding domain of influenza A virus H1N1 polymerase subunit PB2.

Liu Y, Meng G, Luo M, Zheng X.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Mar 1;69(Pt 3):280-3. doi: 10.1107/S1744309113002388. Epub 2013 Feb 22.

9.

A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs.

Fodor E, Crow M, Mingay LJ, Deng T, Sharps J, Fechter P, Brownlee GG.

J Virol. 2002 Sep;76(18):8989-9001.

10.

Specific residues of PB2 and PA influenza virus polymerase subunits confer the ability for RNA polymerase II degradation and virus pathogenicity in mice.

Llompart CM, Nieto A, Rodriguez-Frandsen A.

J Virol. 2014 Mar;88(6):3455-63. doi: 10.1128/JVI.02263-13. Epub 2014 Jan 8.

12.

The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.

Graef KM, Vreede FT, Lau YF, McCall AW, Carr SM, Subbarao K, Fodor E.

J Virol. 2010 Sep;84(17):8433-45. doi: 10.1128/JVI.00879-10. Epub 2010 Jun 10.

13.

Molecular Basis of mRNA Cap Recognition by Influenza B Polymerase PB2 Subunit.

Xie L, Wartchow C, Shia S, Uehara K, Steffek M, Warne R, Sutton J, Muiru GT, Leonard VH, Bussiere DE, Ma X.

J Biol Chem. 2016 Jan 1;291(1):363-70. doi: 10.1074/jbc.M115.693051. Epub 2015 Nov 11.

14.

Amino acid changes in the influenza A virus PA protein that attenuate avian H5N1 viruses in mammals.

Fan S, Hatta M, Kim JH, Le MQ, Neumann G, Kawaoka Y.

J Virol. 2014 Dec;88(23):13737-46. doi: 10.1128/JVI.01081-14. Epub 2014 Sep 17.

15.

Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus.

He X, Zhou J, Bartlam M, Zhang R, Ma J, Lou Z, Li X, Li J, Joachimiak A, Zeng Z, Ge R, Rao Z, Liu Y.

Nature. 2008 Aug 28;454(7208):1123-6. doi: 10.1038/nature07120. Epub 2008 Jul 9.

PMID:
18615018
16.

Multiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human Cells.

Mänz B, de Graaf M, Mögling R, Richard M, Bestebroer TM, Rimmelzwaan GF, Fouchier RA.

J Virol. 2016 Jun 10;90(13):5928-38. doi: 10.1128/JVI.00130-16. Print 2016 Jul 1.

17.
18.

Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription.

Reguera J, Weber F, Cusack S.

PLoS Pathog. 2010 Sep 16;6(9):e1001101. doi: 10.1371/journal.ppat.1001101.

19.

The crystal structure of the PB2 cap-binding domain of influenza B virus reveals a novel cap recognition mechanism.

Liu Y, Yang Y, Fan J, He R, Luo M, Zheng X.

J Biol Chem. 2015 Apr 3;290(14):9141-9. doi: 10.1074/jbc.M115.636464. Epub 2015 Feb 17.

20.

Biophysical characterization of sites of host adaptive mutation in the influenza A virus RNA polymerase PB2 RNA-binding domain.

Lim K, Kim M, Lee MK, Ko J, Hong S, Choi BS.

Int J Biochem Cell Biol. 2014 Aug;53:237-45. doi: 10.1016/j.biocel.2014.05.022. Epub 2014 May 27.

PMID:
24875650

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