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Items: 1 to 20 of 46

1.

Non-invasive UPR monitoring system and its applications in CHO production cultures.

Du Z, Treiber D, McCoy RE, Miller AK, Han M, He F, Domnitz S, Heath C, Reddy P.

Biotechnol Bioeng. 2013 Aug;110(8):2184-94. doi: 10.1002/bit.24877. Epub 2013 Mar 26.

PMID:
23436541
2.

Unfolded protein response in filamentous fungi-implications in biotechnology.

Heimel K.

Appl Microbiol Biotechnol. 2015 Jan;99(1):121-32. doi: 10.1007/s00253-014-6192-7. Epub 2014 Nov 11. Review.

PMID:
25384707
3.

ATF6╬▓-based fine-tuning of the unfolded protein response enhances therapeutic antibody productivity of Chinese hamster ovary cells.

Pieper LA, Strotbek M, Wenger T, Olayioye MA, Hausser A.

Biotechnol Bioeng. 2017 Jun;114(6):1310-1318. doi: 10.1002/bit.26263.

PMID:
28165157
4.

Development of a novel ER stress based selection system for the isolation of highly productive clones.

Kober L, Zehe C, Bode J.

Biotechnol Bioeng. 2012 Oct;109(10):2599-611. doi: 10.1002/bit.24527. Epub 2012 Apr 24.

PMID:
22510960
5.
6.

Identification of novel small molecule enhancers of protein production by cultured mammalian cells.

Allen MJ, Boyce JP, Trentalange MT, Treiber DL, Rasmussen B, Tillotson B, Davis R, Reddy P.

Biotechnol Bioeng. 2008 Aug 15;100(6):1193-204. doi: 10.1002/bit.21839.

PMID:
18351681
7.

Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis.

Genereux JC, Qu S, Zhou M, Ryno LM, Wang S, Shoulders MD, Kaufman RJ, Lasm├ęzas CI, Kelly JW, Wiseman RL.

EMBO J. 2015 Jan 2;34(1):4-19. doi: 10.15252/embj.201488896. Epub 2014 Oct 31.

8.

Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases.

Ryno LM, Wiseman RL, Kelly JW.

Curr Opin Chem Biol. 2013 Jun;17(3):346-52. doi: 10.1016/j.cbpa.2013.04.009. Epub 2013 May 4. Review.

PMID:
23647985
9.

Generation of stable, high-producing CHO cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture.

Oberbek A, Matasci M, Hacker DL, Wurm FM.

Biotechnol Bioeng. 2011 Mar;108(3):600-10. doi: 10.1002/bit.22968. Epub 2010 Nov 23.

PMID:
20967750
10.

HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.

Merquiol E, Uzi D, Mueller T, Goldenberg D, Nahmias Y, Xavier RJ, Tirosh B, Shibolet O.

PLoS One. 2011;6(9):e24660. doi: 10.1371/journal.pone.0024660. Epub 2011 Sep 19.

11.

Kar2p availability defines distinct forms of endoplasmic reticulum stress in living cells.

Lajoie P, Moir RD, Willis IM, Snapp EL.

Mol Biol Cell. 2012 Mar;23(5):955-64. doi: 10.1091/mbc.E11-12-0995. Epub 2012 Jan 4.

12.
13.

Culture temperature modulates aggregation of recombinant antibody in cho cells.

Gomez N, Subramanian J, Ouyang J, Nguyen MD, Hutchinson M, Sharma VK, Lin AA, Yuk IH.

Biotechnol Bioeng. 2012 Jan;109(1):125-36. doi: 10.1002/bit.23288. Epub 2011 Oct 3.

PMID:
21965146
14.

Overexpression of CHOP alone and in combination with chaperones is effective in improving antibody production in mammalian cells.

Nishimiya D, Mano T, Miyadai K, Yoshida H, Takahashi T.

Appl Microbiol Biotechnol. 2013 Mar;97(6):2531-9. doi: 10.1007/s00253-012-4365-9. Epub 2012 Aug 29.

PMID:
22926643
15.

Transcriptional profiling of gene expression changes in a PACE-transfected CHO DUKX cell line secreting high levels of rhBMP-2.

Doolan P, Melville M, Gammell P, Sinacore M, Meleady P, McCarthy K, Francullo L, Leonard M, Charlebois T, Clynes M.

Mol Biotechnol. 2008 Jul;39(3):187-99. doi: 10.1007/s12033-008-9039-6. Epub 2008 Feb 1.

PMID:
18240028
17.

The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: a differential role of unfolded protein response (UPR) signaling proteins.

Lakshmanan AP, Harima M, Suzuki K, Soetikno V, Nagata M, Nakamura T, Takahashi T, Sone H, Kawachi H, Watanabe K.

Int J Biochem Cell Biol. 2013 Feb;45(2):438-47. doi: 10.1016/j.biocel.2012.09.017. Epub 2012 Sep 29.

PMID:
23032698
18.

Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells.

Jorgensen E, Stinson A, Shan L, Yang J, Gietl D, Albino AP.

BMC Cancer. 2008 Aug 11;8:229. doi: 10.1186/1471-2407-8-229.

19.

A comparison of the properties of a Bcl-xL variant to the wild-type anti-apoptosis inhibitor in mammalian cell cultures.

Figueroa B Jr, Sauerwald TM, Oyler GA, Hardwick JM, Betenbaugh MJ.

Metab Eng. 2003 Oct;5(4):230-45.

PMID:
14642351
20.

CHO cells in biotechnology for production of recombinant proteins: current state and further potential.

Kim JY, Kim YG, Lee GM.

Appl Microbiol Biotechnol. 2012 Feb;93(3):917-30. doi: 10.1007/s00253-011-3758-5. Epub 2011 Dec 9. Review.

PMID:
22159888

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