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Items: 1 to 20 of 104

1.

The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover.

Coffey K, Rogerson L, Ryan-Munden C, Alkharaif D, Stockley J, Heer R, Sahadevan K, O'Neill D, Jones D, Darby S, Staller P, Mantilla A, Gaughan L, Robson CN.

Nucleic Acids Res. 2013 Apr;41(8):4433-46. doi: 10.1093/nar/gkt106. Epub 2013 Feb 21.

2.

KDM4B and KDM4A promote endometrial cancer progression by regulating androgen receptor, c-myc, and p27kip1.

Qiu MT, Fan Q, Zhu Z, Kwan SY, Chen L, Chen JH, Ying ZL, Zhou Y, Gu W, Wang LH, Cheng WW, Zeng J, Wan XP, Mok SC, Wong KK, Bao W.

Oncotarget. 2015 Oct 13;6(31):31702-20. doi: 10.18632/oncotarget.5165.

3.

Regulation of c-Myc expression by the histone demethylase JMJD1A is essential for prostate cancer cell growth and survival.

Fan L, Peng G, Sahgal N, Fazli L, Gleave M, Zhang Y, Hussain A, Qi J.

Oncogene. 2016 May 12;35(19):2441-52. doi: 10.1038/onc.2015.309. Epub 2015 Aug 17.

4.

KDM4B is a master regulator of the estrogen receptor signalling cascade.

Gaughan L, Stockley J, Coffey K, O'Neill D, Jones DL, Wade M, Wright J, Moore M, Tse S, Rogerson L, Robson CN.

Nucleic Acids Res. 2013 Aug;41(14):6892-904. doi: 10.1093/nar/gkt469. Epub 2013 May 30.

5.

Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase.

Ipenberg I, Guttmann-Raviv N, Khoury HP, Kupershmit I, Ayoub N.

J Biol Chem. 2013 May 24;288(21):14681-7. doi: 10.1074/jbc.C113.462770. Epub 2013 Apr 15.

6.

KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes.

Duan L, Rai G, Roggero C, Zhang QJ, Wei Q, Ma SH, Zhou Y, Santoyo J, Martinez ED, Xiao G, Raj GV, Jadhav A, Simeonov A, Maloney DJ, Rizo J, Hsieh JT, Liu ZP.

Chem Biol. 2015 Sep 17;22(9):1185-96. doi: 10.1016/j.chembiol.2015.08.007. Epub 2015 Sep 10.

7.

Lgr4 promotes prostate tumorigenesis through the Jmjd2a/AR signaling pathway.

Zhang J, Li Q, Zhang S, Xu Q, Wang T.

Exp Cell Res. 2016 Nov 15;349(1):77-84. doi: 10.1016/j.yexcr.2016.09.023. Epub 2016 Oct 12.

PMID:
27743893
8.

KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor.

Chu CH, Wang LY, Hsu KC, Chen CC, Cheng HH, Wang SM, Wu CM, Chen TJ, Li LT, Liu R, Hung CL, Yang JM, Kung HJ, Wang WC.

J Med Chem. 2014 Jul 24;57(14):5975-85. doi: 10.1021/jm500249n. Epub 2014 Jul 9.

9.

HEXIM1 plays a critical role in the inhibition of the androgen receptor by anti-androgens.

Yeh IJ, Song K, Wittmann BM, Bai X, Danielpour D, Montano MM.

Biochem J. 2014 Sep 1;462(2):315-27. doi: 10.1042/BJ20140174.

PMID:
24844355
10.

Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer.

McClurg UL, Harle VJ, Nabbi A, Batalha-Pereira A, Walker S, Coffey K, Gaughan L, McCracken SR, Robson CN.

Oncotarget. 2015 Nov 10;6(35):37724-36. doi: 10.18632/oncotarget.6075.

11.

Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor.

Burska UL, Harle VJ, Coffey K, Darby S, Ramsey H, O'Neill D, Logan IR, Gaughan L, Robson CN.

J Biol Chem. 2013 Nov 8;288(45):32641-50. doi: 10.1074/jbc.M113.485912. Epub 2013 Sep 21.

12.

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.

Metzger E, Imhof A, Patel D, Kahl P, Hoffmeyer K, Friedrichs N, Müller JM, Greschik H, Kirfel J, Ji S, Kunowska N, Beisenherz-Huss C, Günther T, Buettner R, Schüle R.

Nature. 2010 Apr 1;464(7289):792-6. doi: 10.1038/nature08839. Epub 2010 Mar 14.

PMID:
20228790
13.

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.

Wissmann M, Yin N, Müller JM, Greschik H, Fodor BD, Jenuwein T, Vogler C, Schneider R, Günther T, Buettner R, Metzger E, Schüle R.

Nat Cell Biol. 2007 Mar;9(3):347-53. Epub 2007 Feb 4.

PMID:
17277772
14.

Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1.

Cai C, He HH, Chen S, Coleman I, Wang H, Fang Z, Chen S, Nelson PS, Liu XS, Brown M, Balk SP.

Cancer Cell. 2011 Oct 18;20(4):457-71. doi: 10.1016/j.ccr.2011.09.001.

15.

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription.

Metzger E, Wissmann M, Yin N, Müller JM, Schneider R, Peters AH, Günther T, Buettner R, Schüle R.

Nature. 2005 Sep 15;437(7057):436-9. Epub 2005 Aug 3.

PMID:
16079795
16.

The histone demethylase KDM4B interacts with MyoD to regulate myogenic differentiation in C2C12 myoblast cells.

Choi JH, Song YJ, Lee H.

Biochem Biophys Res Commun. 2015 Jan 24;456(4):872-8. doi: 10.1016/j.bbrc.2014.12.061. Epub 2014 Dec 19.

PMID:
25534856
17.

Histone demethylase Kdm4b functions as a co-factor of C/EBPβ to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes.

Guo L, Li X, Huang JX, Huang HY, Zhang YY, Qian SW, Zhu H, Zhang YD, Liu Y, Liu Y, Wang KK, Tang QQ.

Cell Death Differ. 2012 Dec;19(12):1917-27. doi: 10.1038/cdd.2012.75. Epub 2012 Jun 22.

18.

Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion.

Björkman M, Östling P, Härmä V, Virtanen J, Mpindi JP, Rantala J, Mirtti T, Vesterinen T, Lundin M, Sankila A, Rannikko A, Kaivanto E, Kohonen P, Kallioniemi O, Nees M.

Oncogene. 2012 Jul 19;31(29):3444-56. doi: 10.1038/onc.2011.512. Epub 2011 Nov 28.

PMID:
22120715
19.

Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following γ-irradiation.

Young LC, McDonald DW, Hendzel MJ.

J Biol Chem. 2013 Jul 19;288(29):21376-88. doi: 10.1074/jbc.M113.491514. Epub 2013 Jun 6.

20.

Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer.

Kauffman EC, Robinson BD, Downes MJ, Powell LG, Lee MM, Scherr DS, Gudas LJ, Mongan NP.

Mol Carcinog. 2011 Dec;50(12):931-44. doi: 10.1002/mc.20758. Epub 2011 Mar 11.

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