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Items: 1 to 20 of 152

1.

Identification of molecular alterations in gastrointestinal carcinomas and dysplastic hamartomas in Peutz-Jeghers syndrome.

Korsse SE, Biermann K, Offerhaus GJ, Wagner A, Dekker E, Mathus-Vliegen EM, Kuipers EJ, van Leerdam ME, van Veelen W.

Carcinogenesis. 2013 Jul;34(7):1611-9. doi: 10.1093/carcin/bgt068. Epub 2013 Feb 20.

PMID:
23430953
2.

Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome.

Entius MM, Keller JJ, Westerman AM, van Rees BP, van Velthuysen ML, de Goeij AF, Wilson JH, Giardiello FM, Offerhaus GJ.

J Clin Pathol. 2001 Feb;54(2):126-31.

3.

Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome.

Miyaki M, Iijima T, Hosono K, Ishii R, Yasuno M, Mori T, Toi M, Hishima T, Shitara N, Tamura K, Utsunomiya J, Kobayashi N, Kuroki T, Iwama T.

Cancer Res. 2000 Nov 15;60(22):6311-3.

4.

Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome.

Gruber SB, Entius MM, Petersen GM, Laken SJ, Longo PA, Boyer R, Levin AM, Mujumdar UJ, Trent JM, Kinzler KW, Vogelstein B, Hamilton SR, Polymeropoulos MH, Offerhaus GJ, Giardiello FM.

Cancer Res. 1998 Dec 1;58(23):5267-70.

5.

Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas.

De Leng WW, Westerman AM, Weterman MA, De Rooij FW, Dekken Hv Hv, De Goeij AF, Gruber SB, Wilson JH, Offerhaus GJ, Giardiello FM, Keller JJ.

Clin Cancer Res. 2003 Aug 1;9(8):3065-72.

6.

Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.

Wang ZJ, Ellis I, Zauber P, Iwama T, Marchese C, Talbot I, Xue WH, Yan ZY, Tomlinson I.

J Pathol. 1999 May;188(1):9-13.

PMID:
10398133
7.

Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice.

Takeda H, Miyoshi H, Kojima Y, Oshima M, Taketo MM.

Oncogene. 2006 Mar 16;25(12):1816-20.

PMID:
16278673
8.

Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis.

Wei C, Amos CI, Stephens LC, Campos I, Deng JM, Behringer RR, Rashid A, Frazier ML.

Cancer Res. 2005 Dec 15;65(24):11297-303.

9.

Nasal polyposis in Peutz-Jeghers syndrome: a distinct histopathological and molecular genetic entity.

de Leng WW, Westerman AM, Weterman MA, Jansen M, van Dekken H, Giardiello FM, de Rooij FW, Paul Wilson JH, Offerhaus GJ, Keller JJ.

J Clin Pathol. 2007 Apr;60(4):392-6. Epub 2006 Jun 14.

10.

Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.

Miyoshi H, Nakau M, Ishikawa TO, Seldin MF, Oshima M, Taketo MM.

Cancer Res. 2002 Apr 15;62(8):2261-6.

11.

De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome.

Hernan I, Roig I, Martin B, Gamundi MJ, Martinez-Gimeno M, Carballo M.

Clin Genet. 2004 Jul;66(1):58-62.

PMID:
15200509
12.

[Peutz-Jeghers syndrome].

Miyaki M.

Nihon Rinsho. 2000 Jul;58(7):1400-4. Review. Japanese.

PMID:
10921312
13.

Wnt signaling may be activated in a subset of Peutz-Jeghers syndrome polyps closely correlating to LKB1 expression.

Ma Y, Zhang G, Fu X, Xia O, Zhan C, Li L, Wang Z, Wu B.

Oncol Rep. 2010 Jun;23(6):1569-76.

PMID:
20428811
14.
15.

LKB1 mutations frequently detected in mucinous bronchioloalveolar carcinoma.

Osoegawa A, Kometani T, Nosaki K, Ondo K, Hamatake M, Hirai F, Seto T, Sugio K, Ichinose Y.

Jpn J Clin Oncol. 2011 Sep;41(9):1132-7. doi: 10.1093/jjco/hyr102. Epub 2011 Aug 4.

PMID:
21816872
16.

Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.

Lim W, Hearle N, Shah B, Murday V, Hodgson SV, Lucassen A, Eccles D, Talbot I, Neale K, Lim AG, O'Donohue J, Donaldson A, Macdonald RC, Young ID, Robinson MH, Lee PW, Stoodley BJ, Tomlinson I, Alderson D, Holbrook AG, Vyas S, Swarbrick ET, Lewis AA, Phillips RK, Houlston RS.

Br J Cancer. 2003 Jul 21;89(2):308-13.

17.

Genetic heterogeneity in Peutz-Jeghers syndrome.

Boardman LA, Couch FJ, Burgart LJ, Schwartz D, Berry R, McDonnell SK, Schaid DJ, Hartmann LC, Schroeder JJ, Stratakis CA, Thibodeau SN.

Hum Mutat. 2000;16(1):23-30.

PMID:
10874301
18.

STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas.

Sato N, Rosty C, Jansen M, Fukushima N, Ueki T, Yeo CJ, Cameron JL, Iacobuzio-Donahue CA, Hruban RH, Goggins M.

Am J Pathol. 2001 Dec;159(6):2017-22.

19.

Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.

Mehenni H, Gehrig C, Nezu J, Oku A, Shimane M, Rossier C, Guex N, Blouin JL, Scott HS, Antonarakis SE.

Am J Hum Genet. 1998 Dec;63(6):1641-50.

20.

A novel de novo mutation in LKB1 gene in a Chinese Peutz Jeghers syndrome patient significantly diminished p53 activity.

Liu L, Du X, Nie J.

Clin Res Hepatol Gastroenterol. 2011 Mar;35(3):221-6. doi: 10.1016/j.clinre.2010.11.008. Epub 2011 Mar 15.

PMID:
21411391

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