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Items: 1 to 20 of 139

1.

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

Ben-Sahra I, Howell JJ, Asara JM, Manning BD.

Science. 2013 Mar 15;339(6125):1323-8. doi: 10.1126/science.1228792. Epub 2013 Feb 21.

2.

Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis.

Robitaille AM, Christen S, Shimobayashi M, Cornu M, Fava LL, Moes S, Prescianotto-Baschong C, Sauer U, Jenoe P, Hall MN.

Science. 2013 Mar 15;339(6125):1320-3. doi: 10.1126/science.1228771. Epub 2013 Feb 21.

3.

Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity.

Sato T, Akasu H, Shimono W, Matsu C, Fujiwara Y, Shibagaki Y, Heard JJ, Tamanoi F, Hattori S.

J Biol Chem. 2015 Jan 9;290(2):1096-105. doi: 10.1074/jbc.M114.592402. Epub 2014 Nov 24.

4.

Association of CAD, a multifunctional protein involved in pyrimidine synthesis, with mLST8, a component of the mTOR complexes.

Nakashima A, Kawanishi I, Eguchi S, Yu EH, Eguchi S, Oshiro N, Yoshino K, Kikkawa U, Yonezawa K.

J Biomed Sci. 2013 Apr 18;20:24. doi: 10.1186/1423-0127-20-24.

5.

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.

Rabinovich S, Adler L, Yizhak K, Sarver A, Silberman A, Agron S, Stettner N, Sun Q, Brandis A, Helbling D, Korman S, Itzkovitz S, Dimmock D, Ulitsky I, Nagamani SC, Ruppin E, Erez A.

Nature. 2015 Nov 19;527(7578):379-383. doi: 10.1038/nature15529. Epub 2015 Nov 11.

7.

Targeting mTORC1-mediated metabolic addiction overcomes fludarabine resistance in malignant B cells.

Sharma A, Janocha AJ, Hill BT, Smith MR, Erzurum SC, Almasan A.

Mol Cancer Res. 2014 Sep;12(9):1205-15. doi: 10.1158/1541-7786.MCR-14-0124. Epub 2014 Jul 24.

8.

Molecular interaction of the first 3 enzymes of the de novo pyrimidine biosynthetic pathway of Trypanosoma cruzi.

Nara T, Hashimoto M, Hirawake H, Liao CW, Fukai Y, Suzuki S, Tsubouchi A, Morales J, Takamiya S, Fujimura T, Taka H, Mineki R, Fan CK, Inaoka DK, Inoue M, Tanaka A, Harada S, Kita K, Aoki T.

Biochem Biophys Res Commun. 2012 Feb 3;418(1):140-3. doi: 10.1016/j.bbrc.2011.12.148. Epub 2012 Jan 8.

PMID:
22245425
11.

The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD.

Lindsey-Boltz LA, Wauson EM, Graves LM, Sancar A.

Nucleic Acids Res. 2004 Aug 23;32(15):4524-30. Print 2004.

13.
14.

Regulation of carbamoyl phosphate synthetase by MAP kinase.

Graves LM, Guy HI, Kozlowski P, Huang M, Lazarowski E, Pope RM, Collins MA, Dahlstrand EN, Earp HS 3rd, Evans DR.

Nature. 2000 Jan 20;403(6767):328-32.

PMID:
10659854
15.

De novo synthesis of pyrimidine nucleotides; emerging interfaces with signal transduction pathways.

Huang M, Graves LM.

Cell Mol Life Sci. 2003 Feb;60(2):321-36. Review.

PMID:
12678497
16.

Cell cycle-dependent regulation of pyrimidine biosynthesis.

Sigoillot FD, Berkowski JA, Sigoillot SM, Kotsis DH, Guy HI.

J Biol Chem. 2003 Jan 31;278(5):3403-9. Epub 2002 Nov 15.

17.

Chemotherapeutic inhibitors of the enzymes of the de novo pyrimidine pathway.

Kensler TW, Cooney DA.

Adv Pharmacol Chemother. 1981;18:273-352. Review. No abstract available.

PMID:
6119898
20.

Characterization of pyrimidine metabolism in the cellular slime mold, Dictyostelium discoideum.

Wales ME, Mann-Dean MG, Wild JR.

Can J Microbiol. 1989 Apr;35(4):432-8.

PMID:
2568162

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