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Items: 1 to 20 of 159

1.

Inhibition of H3K9 methyltransferases G9a/GLP prevents ototoxicity and ongoing hair cell death.

Yu H, Lin Q, Wang Y, He Y, Fu S, Jiang H, Yu Y, Sun S, Chen Y, Shou J, Li H.

Cell Death Dis. 2013 Feb 21;4:e506. doi: 10.1038/cddis.2013.28.

2.

A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss.

Wang J, Van De Water TR, Bonny C, de Ribaupierre F, Puel JL, Zine A.

J Neurosci. 2003 Sep 17;23(24):8596-607.

3.

Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294.

Imai K, Togami H, Okamoto T.

J Biol Chem. 2010 May 28;285(22):16538-45. doi: 10.1074/jbc.M110.103531.

4.

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.

Kubicek S, O'Sullivan RJ, August EM, Hickey ER, Zhang Q, Teodoro ML, Rea S, Mechtler K, Kowalski JA, Homon CA, Kelly TA, Jenuwein T.

Mol Cell. 2007 Feb 9;25(3):473-81.

5.

Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells.

Tao H, Li H, Su Y, Feng D, Wang X, Zhang C, Ma H, Hu Q.

Mol Cell Biochem. 2014 Sep;394(1-2):23-30. doi: 10.1007/s11010-014-2077-4.

PMID:
24833465
6.
7.

Inhibition of H3K4me2 Demethylation Protects Auditory Hair Cells from Neomycin-Induced Apoptosis.

He Y, Yu H, Cai C, Sun S, Chai R, Li H.

Mol Neurobiol. 2015 Aug;52(1):196-205. doi: 10.1007/s12035-014-8841-3.

PMID:
25132091
8.

Leupeptin, a calpain inhibitor, protects inner ear hair cells from aminoglycoside ototoxicity.

Momiyama J, Hashimoto T, Matsubara A, Futai K, Namba A, Shinkawa H.

Tohoku J Exp Med. 2006 Jun;209(2):89-97.

9.

G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation.

Gupta-Agarwal S, Franklin AV, Deramus T, Wheelock M, Davis RL, McMahon LL, Lubin FD.

J Neurosci. 2012 Apr 18;32(16):5440-53. doi: 10.1523/JNEUROSCI.0147-12.2012.

10.

Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.

Tachibana M, Ueda J, Fukuda M, Takeda N, Ohta T, Iwanari H, Sakihama T, Kodama T, Hamakubo T, Shinkai Y.

Genes Dev. 2005 Apr 1;19(7):815-26.

11.

H3K9 methyltransferase G9a and the related molecule GLP.

Shinkai Y, Tachibana M.

Genes Dev. 2011 Apr 15;25(8):781-8. doi: 10.1101/gad.2027411. Review.

12.

G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription.

Tachibana M, Matsumura Y, Fukuda M, Kimura H, Shinkai Y.

EMBO J. 2008 Oct 22;27(20):2681-90. doi: 10.1038/emboj.2008.192.

13.

Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression.

Irifuku T, Doi S, Sasaki K, Doi T, Nakashima A, Ueno T, Yamada K, Arihiro K, Kohno N, Masaki T.

Kidney Int. 2016 Jan;89(1):147-57. doi: 10.1038/ki.2015.291.

PMID:
26444031
14.

G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment.

Chen X, Skutt-Kakaria K, Davison J, Ou YL, Choi E, Malik P, Loeb K, Wood B, Georges G, Torok-Storb B, Paddison PJ.

Genes Dev. 2012 Nov 15;26(22):2499-511. doi: 10.1101/gad.200329.112.

15.

Posttranscriptional regulation of histone lysine methyltransferase GLP in embryonic male mouse germ cells.

Deguchi K, Nagamatsu G, Miyachi H, Kato Y, Morita S, Kimura H, Kitano S, Hatada I, Saga Y, Tachibana M, Shinkai Y.

Biol Reprod. 2013 Feb 14;88(2):36. doi: 10.1095/biolreprod.112.103572.

16.

Inhibition of H3K9 methyltransferase G9a induces autophagy and apoptosis in oral squamous cell carcinoma.

Ren A, Qiu Y, Cui H, Fu G.

Biochem Biophys Res Commun. 2015 Mar 27;459(1):10-7. doi: 10.1016/j.bbrc.2015.01.068.

PMID:
25634693
17.

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.

Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, Mangano TJ, Huang XP, Simpson CD, Pattenden SG, Norris JL, Kireev DB, Tripathy A, Edwards A, Roth BL, Janzen WP, Garcia BA, Petronis A, Ellis J, Brown PJ, Frye SV, Arrowsmith CH, Jin J.

Nat Chem Biol. 2011 Jul 10;7(8):566-74. doi: 10.1038/nchembio.599. Erratum in: Nat Chem Biol. 2011 Sep;7(9):648. Nat Chem Biol. 2011;7(8):following 574.

18.

The Dynamics and Regulatory Mechanism of Pronuclear H3k9me2 Asymmetry in Mouse Zygotes.

Ma XS, Chao SB, Huang XJ, Lin F, Qin L, Wang XG, Meng TG, Zhu CC, Schatten H, Liu HL, Sun QY.

Sci Rep. 2015 Dec 7;5:17924. doi: 10.1038/srep17924.

19.

Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice.

Subbanna S, Nagre NN, Shivakumar M, Umapathy NS, Psychoyos D, Basavarajappa BS.

Neuroscience. 2014 Jan 31;258:422-32. doi: 10.1016/j.neuroscience.2013.11.043.

20.

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.

Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, Fukuda M, Takeda N, Niida H, Kato H, Shinkai Y.

Genes Dev. 2002 Jul 15;16(14):1779-91.

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