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Items: 1 to 20 of 132

1.

Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection.

Yan J, Kaur S, DeLucia M, Hao C, Mehrens J, Wang C, Golczak M, Palczewski K, Gronenborn AM, Ahn J, Skowronski J.

J Biol Chem. 2013 Apr 12;288(15):10406-17. doi: 10.1074/jbc.M112.443796. Epub 2013 Feb 20.

2.

HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation.

DeLucia M, Mehrens J, Wu Y, Ahn J.

J Biol Chem. 2013 Jun 28;288(26):19116-26. doi: 10.1074/jbc.M113.469007. Epub 2013 May 15.

3.

Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac.

Brandariz-Nuñez A, Valle-Casuso JC, White TE, Laguette N, Benkirane M, Brojatsch J, Diaz-Griffero F.

Retrovirology. 2012 Jun 12;9:49. doi: 10.1186/1742-4690-9-49.

4.

Degradation of SAMHD1 by Vpx Is Independent of Uncoating.

Jáuregui P, Logue EC, Schultz ML, Fung S, Landau NR.

J Virol. 2015 May;89(10):5701-13. doi: 10.1128/JVI.03575-14. Epub 2015 Mar 11.

5.

Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1.

Fregoso OI, Ahn J, Wang C, Mehrens J, Skowronski J, Emerman M.

PLoS Pathog. 2013;9(7):e1003496. doi: 10.1371/journal.ppat.1003496. Epub 2013 Jul 18.

6.

Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase.

Zhu C, Gao W, Zhao K, Qin X, Zhang Y, Peng X, Zhang L, Dong Y, Zhang W, Li P, Wei W, Gong Y, Yu XF.

Nat Commun. 2013;4:2722. doi: 10.1038/ncomms3722.

PMID:
24217394
7.

A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.

Bloch N, Gläsker S, Sitaram P, Hofmann H, Shepard CN, Schultz ML, Kim B, Landau NR.

J Biol Chem. 2017 Jan 20;292(3):1068-1080. doi: 10.1074/jbc.M116.743740. Epub 2016 Dec 5.

PMID:
27920203
8.

Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.

White TE, Brandariz-Nuñez A, Valle-Casuso JC, Amie S, Nguyen L, Kim B, Brojatsch J, Diaz-Griffero F.

Virology. 2013 Feb 5;436(1):81-90. doi: 10.1016/j.virol.2012.10.029. Epub 2012 Nov 13.

9.

HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.

Ahn J, Hao C, Yan J, DeLucia M, Mehrens J, Wang C, Gronenborn AM, Skowronski J.

J Biol Chem. 2012 Apr 6;287(15):12550-8. doi: 10.1074/jbc.M112.340711. Epub 2012 Feb 23.

10.

HD domain of SAMHD1 influences Vpx-induced degradation at a post-interaction step.

Kang J, Hou J, Zhao K, Yu XF, Du J.

Biochem Biophys Res Commun. 2016 Feb 12;470(3):690-6. doi: 10.1016/j.bbrc.2016.01.080. Epub 2016 Jan 15.

PMID:
26779819
11.

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.

Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, König R, Fackler OT, Keppler OT.

Nat Med. 2012 Nov;18(11):1682-7. doi: 10.1038/nm.2964.

12.

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx.

Laguette N, Sobhian B, Casartelli N, Ringeard M, Chable-Bessia C, Ségéral E, Yatim A, Emiliani S, Schwartz O, Benkirane M.

Nature. 2011 May 25;474(7353):654-7. doi: 10.1038/nature10117.

13.

Mechanism of allosteric activation of SAMHD1 by dGTP.

Ji X, Wu Y, Yan J, Mehrens J, Yang H, DeLucia M, Hao C, Gronenborn AM, Skowronski J, Ahn J, Xiong Y.

Nat Struct Mol Biol. 2013 Nov;20(11):1304-9. doi: 10.1038/nsmb.2692. Epub 2013 Oct 20.

14.

Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply.

Dragin L, Nguyen LA, Lahouassa H, Sourisce A, Kim B, Ramirez BC, Margottin-Goguet F.

Retrovirology. 2013 Mar 11;10:30. doi: 10.1186/1742-4690-10-30.

15.

Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1.

Welbourn S, Dutta SM, Semmes OJ, Strebel K.

J Virol. 2013 Nov;87(21):11516-24. doi: 10.1128/JVI.01642-13. Epub 2013 Aug 21.

16.

Characterization of the interactions between SIVrcm Vpx and red-capped mangabey SAMHD1.

Li J, Xu F, Hu S, Zhou J, Mei S, Zhao X, Cen S, Jin Q, Liang C, Guo F.

Biochem J. 2015 Jun 1;468(2):303-13. doi: 10.1042/BJ20141331.

PMID:
25791246
17.

Structural basis of cellular dNTP regulation by SAMHD1.

Ji X, Tang C, Zhao Q, Wang W, Xiong Y.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4305-14. doi: 10.1073/pnas.1412289111. Epub 2014 Sep 29.

18.

GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state.

Hansen EC, Seamon KJ, Cravens SL, Stivers JT.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1843-51. doi: 10.1073/pnas.1401706111. Epub 2014 Apr 21.

19.

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.

Ryoo J, Choi J, Oh C, Kim S, Seo M, Kim SY, Seo D, Kim J, White TE, Brandariz-Nuñez A, Diaz-Griffero F, Yun CH, Hollenbaugh JA, Kim B, Baek D, Ahn K.

Nat Med. 2014 Aug;20(8):936-41. doi: 10.1038/nm.3626. Epub 2014 Jul 20.

20.

Structural Insights into the High-efficiency Catalytic Mechanism of the Sterile α-Motif/Histidine-Aspartate Domain-containing Protein.

Li Y, Kong J, Peng X, Hou W, Qin X, Yu XF.

J Biol Chem. 2015 Dec 4;290(49):29428-37. doi: 10.1074/jbc.M115.663658. Epub 2015 Oct 5.

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