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Items: 1 to 20 of 310

1.

Synthesis and biological evaluation of novel pyranochalcone derivatives as a new class of microtubule stabilizing agents.

Cao D, Han X, Wang G, Yang Z, Peng F, Ma L, Zhang R, Ye H, Tang M, Wu W, Lei K, Wen J, Chen J, Qiu J, Liang X, Ran Y, Sang Y, Xiang M, Peng A, Chen L.

Eur J Med Chem. 2013 Apr;62:579-89. doi: 10.1016/j.ejmech.2013.01.007. Epub 2013 Jan 16.

PMID:
23425970
2.

Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents.

Wang G, Wu W, Peng F, Cao D, Yang Z, Ma L, Qiu N, Ye H, Han X, Chen J, Qiu J, Sang Y, Liang X, Ran Y, Peng A, Wei Y, Chen L.

Eur J Med Chem. 2012 Aug;54:793-803. doi: 10.1016/j.ejmech.2012.06.034. Epub 2012 Jun 23.

PMID:
22784822
3.

Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents.

Wang G, Li C, He L, Lei K, Wang F, Pu Y, Yang Z, Cao D, Ma L, Chen J, Sang Y, Liang X, Xiang M, Peng A, Wei Y, Chen L.

Bioorg Med Chem. 2014 Apr 1;22(7):2060-79. doi: 10.1016/j.bmc.2014.02.028. Epub 2014 Mar 1.

PMID:
24629450
4.

A new diaryl urea compound, D181, induces cell cycle arrest in the G1 and M phases by targeting receptor tyrosine kinases and the microtubule skeleton.

Zhang J, Zhou J, Ren X, Diao Y, Li H, Jiang H, Ding K, Pei D.

Invest New Drugs. 2012 Apr;30(2):490-507. doi: 10.1007/s10637-010-9577-1. Epub 2010 Nov 16.

PMID:
21080210
5.

Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors.

Wang G, Peng F, Cao D, Yang Z, Han X, Liu J, Wu W, He L, Ma L, Chen J, Sang Y, Xiang M, Peng A, Wei Y, Chen L.

Bioorg Med Chem. 2013 Nov 1;21(21):6844-54. doi: 10.1016/j.bmc.2013.02.002. Epub 2013 Feb 13.

PMID:
23993668
6.

Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents.

Liu Y, Wei D, Zhao Y, Cheng W, Lu Y, Ma Y, Li X, Han C, Wei Y, Cao H, Zhao C.

Bioorg Med Chem. 2012 Nov 1;20(21):6285-95. doi: 10.1016/j.bmc.2012.09.009. Epub 2012 Sep 13.

PMID:
23022053
7.

Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors.

Yang Z, Wu W, Wang J, Liu L, Li L, Yang J, Wang G, Cao D, Zhang R, Tang M, Wen J, Zhu J, Xiang W, Wang F, Ma L, Xiang M, You J, Chen L.

J Med Chem. 2014 Oct 9;57(19):7977-89. doi: 10.1021/jm500849z. Epub 2014 Sep 29.

PMID:
25208345
8.

Design, synthesis and biological evaluation of novel pyrazoline-containing derivatives as potential tubulin assembling inhibitors.

Qin YJ, Li YJ, Jiang AQ, Yang MR, Zhu QZ, Dong H, Zhu HL.

Eur J Med Chem. 2015 Apr 13;94:447-57. doi: 10.1016/j.ejmech.2015.02.058. Epub 2015 Mar 3.

PMID:
25828827
9.

Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors.

Cao D, Liu Y, Yan W, Wang C, Bai P, Wang T, Tang M, Wang X, Yang Z, Ma B, Ma L, Lei L, Wang F, Xu B, Zhou Y, Yang T, Chen L.

J Med Chem. 2016 Jun 23;59(12):5721-39. doi: 10.1021/acs.jmedchem.6b00158. Epub 2016 Jun 2.

PMID:
27213819
10.

Synthesis and biological evaluation of 1-benzylidene-3,4-dihydronaphthalen-2-one as a new class of microtubule-targeting agents.

Liu J, Zheng CH, Ren XH, Zhou F, Li W, Zhu J, Lv JG, Zhou YJ.

J Med Chem. 2012 Jun 28;55(12):5720-33. doi: 10.1021/jm300596s. Epub 2012 Jun 15.

PMID:
22676247
11.

(Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies.

Reddy MV, Akula B, Cosenza SC, Lee CM, Mallireddigari MR, Pallela VR, Subbaiah DR, Udofa A, Reddy EP.

J Med Chem. 2012 Jun 14;55(11):5174-87. doi: 10.1021/jm300176j. Epub 2012 May 25.

12.

Synthesis of macrocyclic bisbibenzyl derivatives and their anticancer effects as anti-tubulin agents.

Jiang J, Sun B, Wang YY, Cui M, Zhang L, Cui CZ, Wang YF, Liu XG, Lou HX.

Bioorg Med Chem. 2012 Apr 1;20(7):2382-91. doi: 10.1016/j.bmc.2012.02.004. Epub 2012 Feb 9.

PMID:
22365913
13.

Discovery of novel 2-N-aryl-substituted benzenesulfonamidoacetamides: orally bioavailable tubulin polymerization inhibitors with marked antitumor activities.

Liu Z, Zhou Z, Tian W, Fan X, Xue D, Yu L, Yu Q, Long YQ.

ChemMedChem. 2012 Apr;7(4):680-93. doi: 10.1002/cmdc.201100529. Epub 2012 Feb 6.

PMID:
22311585
14.

9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Zuse A, Schmidt P, Baasner S, Böhm KJ, Müller K, Gerlach M, Günther EG, Unger E, Prinz H.

J Med Chem. 2006 Dec 28;49(26):7816-25.

PMID:
17181164
15.

YSL-12, a novel microtubule-destabilizing agent, exerts potent anti-tumor activity against colon cancer in vitro and in vivo.

Cai D, Qiu Z, Yao W, Liu Y, Huang H, Liao S, Luo Q, Xie L, Lin Z.

Cancer Chemother Pharmacol. 2016 Jun;77(6):1217-29. doi: 10.1007/s00280-016-3036-4. Epub 2016 Apr 23.

PMID:
27107592
16.

Synthesis, biological evaluation and molecular docking studies of resveratrol derivatives possessing curcumin moiety as potent antitubulin agents.

Ruan BF, Lu X, Li TT, Tang JF, Wei Y, Wang XL, Zheng SL, Yao RS, Zhu HL.

Bioorg Med Chem. 2012 Jan 15;20(2):1113-21. doi: 10.1016/j.bmc.2011.11.017. Epub 2011 Dec 1.

PMID:
22189271
17.

New benzimidazole-2-urea derivates as tubulin inhibitors.

Wang W, Kong D, Cheng H, Tan L, Zhang Z, Zhuang X, Long H, Zhou Y, Xu Y, Yang X, Ding K.

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4250-3. doi: 10.1016/j.bmcl.2014.07.035. Epub 2014 Jul 17.

PMID:
25091926
18.

Synthesis and biological evaluation of 1-phenyl-1,2,3,4-dihydroisoquinoline compounds as tubulin polymerization inhibitors.

Zheng CH, Chen J, Liu J, Zhou XT, Liu N, Shi D, Huang JJ, Lv JG, Zhu J, Zhou YJ.

Arch Pharm (Weinheim). 2012 Jun;345(6):454-62. doi: 10.1002/ardp.201100169. Epub 2012 Mar 13.

PMID:
22415658
19.

Induction of apoptosis through tubulin inhibition in human cancer cells by new chromene-based chalcones.

Aryapour H, Riazi GH, Ahmadian S, Foroumadi A, Mahdavi M, Emami S.

Pharm Biol. 2012 Dec;50(12):1551-60. doi: 10.3109/13880209.2012.695799. Epub 2012 Sep 18.

PMID:
22984888
20.

4- and 5-aroylindoles as novel classes of potent antitubulin agents.

Liou JP, Wu CY, Hsieh HP, Chang CY, Chen CM, Kuo CC, Chang JY.

J Med Chem. 2007 Sep 6;50(18):4548-52. Epub 2007 Aug 8.

PMID:
17685504

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