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Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.

Shafqat N, Muniz JR, Pilka ES, Papagrigoriou E, von Delft F, Oppermann U, Yue WW.

Biochem J. 2013 May 15;452(1):27-36. doi: 10.1042/BJ20121580.


Methionine adenosyltransferase 2A/2B and methylation: gene sequence variation and functional genomics.

Nordgren KK, Peng Y, Pelleymounter LL, Moon I, Abo R, Feng Q, Eckloff B, Yee VC, Wieben E, Weinshilboum RM.

Drug Metab Dispos. 2011 Nov;39(11):2135-47. doi: 10.1124/dmd.111.040857. Epub 2011 Aug 3.


Crystal structures of methionine adenosyltransferase complexed with substrates and products reveal the methionine-ATP recognition and give insights into the catalytic mechanism.

González B, Pajares MA, Hermoso JA, Guillerm D, Guillerm G, Sanz-Aparicio J.

J Mol Biol. 2003 Aug 8;331(2):407-16.


Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.

Frau M, Feo F, Pascale RM.

J Hepatol. 2013 Oct;59(4):830-41. doi: 10.1016/j.jhep.2013.04.031. Epub 2013 May 7. Review.


Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression in the rat.

Huang ZZ, Mato JM, Kanel G, Lu SC.

Hepatology. 1999 May;29(5):1471-8.


Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.

Quinlan CL, Kaiser SE, Bolaños B, Nowlin D, Grantner R, Karlicek-Bryant S, Feng JL, Jenkinson S, Freeman-Cook K, Dann SG, Wang X, Wells PA, Fantin VR, Stewart AE, Grant SK.

Nat Chem Biol. 2017 Jul;13(7):785-792. doi: 10.1038/nchembio.2384. Epub 2017 May 29.


The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases.

Pérez C, Pérez-Zúñiga FJ, Garrido F, Reytor E, Portillo F, Pajares MA.

PLoS One. 2016 Aug 22;11(8):e0161672. doi: 10.1371/journal.pone.0161672. eCollection 2016. Erratum in: PLoS One. 2016;11(9):e0163761.


Structure-function relationships in methionine adenosyltransferases.

Markham GD, Pajares MA.

Cell Mol Life Sci. 2009 Feb;66(4):636-48. doi: 10.1007/s00018-008-8516-1. Review.


Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes.

Murray B, Antonyuk SV, Marina A, Lu SC, Mato JM, Hasnain SS, Rojas AL.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2104-9. doi: 10.1073/pnas.1510959113. Epub 2016 Feb 8.


Metabolic aspects of epigenome: coupling of S-adenosylmethionine synthesis and gene regulation on chromatin by SAMIT module.

Igarashi K, Katoh Y.

Subcell Biochem. 2013;61:105-18. doi: 10.1007/978-94-007-4525-4_5. Review.


The crystal structure of tetrameric methionine adenosyltransferase from rat liver reveals the methionine-binding site.

González B, Pajares MA, Hermoso JA, Alvarez L, Garrido F, Sufrin JR, Sanz-Aparicio J.

J Mol Biol. 2000 Jul 7;300(2):363-75.


Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus.

Wang F, Singh S, Zhang J, Huber TD, Helmich KE, Sunkara M, Hurley KA, Goff RD, Bingman CA, Morris AJ, Thorson JS, Phillips GN Jr.

FEBS J. 2014 Sep;281(18):4224-39. doi: 10.1111/febs.12784. Epub 2014 Apr 7.


HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis.

Vázquez-Chantada M, Fernández-Ramos D, Embade N, Martínez-Lopez N, Varela-Rey M, Woodhoo A, Luka Z, Wagner C, Anglim PP, Finnell RH, Caballería J, Laird-Offringa IA, Gorospe M, Lu SC, Mato JM, Martínez-Chantar ML.

Gastroenterology. 2010 May;138(5):1943-53. doi: 10.1053/j.gastro.2010.01.032. Epub 2010 Jan 25.


MicroRNA-21-3p, a berberine-induced miRNA, directly down-regulates human methionine adenosyltransferases 2A and 2B and inhibits hepatoma cell growth.

Lo TF, Tsai WC, Chen ST.

PLoS One. 2013 Sep 30;8(9):e75628. doi: 10.1371/journal.pone.0075628. eCollection 2013.


Regulation of mammalian liver methionine adenosyltransferase.

Corrales FJ, Pérez-Mato I, Sánchez Del Pino MM, Ruiz F, Castro C, García-Trevijano ER, Latasa U, Martínez-Chantar ML, Martínez-Cruz A, Avila MA, Mato JM.

J Nutr. 2002 Aug;132(8 Suppl):2377S-2381S.


Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer.

Yang H, Huang ZZ, Zeng Z, Chen C, Selby RR, Lu SC.

Am J Physiol Gastrointest Liver Physiol. 2001 Feb;280(2):G184-90.

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