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Regulatory motifs in Chk1.

Caparelli ML, O'Connell MJ.

Cell Cycle. 2013 Mar 15;12(6):916-22. doi: 10.4161/cc.23881. Epub 2013 Feb 19.


Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.

Qu M, Yang B, Tao L, Yates JR 3rd, Russell P, Dong MQ, Du LL.

PLoS Genet. 2012 Jul;8(7):e1002817. doi: 10.1371/journal.pgen.1002817. Epub 2012 Jul 5.


Regulation of checkpoint kinases through dynamic interaction with Crb2.

Mochida S, Esashi F, Aono N, Tamai K, O'Connell MJ, Yanagida M.

EMBO J. 2004 Jan 28;23(2):418-28. Epub 2004 Jan 22.


Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.

Nakamura TM, Du LL, Redon C, Russell P.

Mol Cell Biol. 2004 Jul;24(14):6215-30. Erratum in: Mol Cell Biol. 2004 Sep;24(17):7820.


Conserved ATRMec1 phosphorylation-independent activation of Chk1 by single amino acid substitution in the GD domain.

Pereira E, Chen Y, Sanchez Y.

Cell Cycle. 2009 Jun 1;8(11):1788-93. Epub 2009 Jun 15.


Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast.

Lopez-Girona A, Tanaka K, Chen XB, Baber BA, McGowan CH, Russell P.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11289-94. Epub 2001 Sep 11.


KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage.

Gong EY, Smits VA, Fumagallo F, Piscitello D, Morrice N, Freire R, Gillespie DA.

Sci Rep. 2015 Jun 3;5:10856. doi: 10.1038/srep10856.


Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair.

Kilkenny ML, Doré AS, Roe SM, Nestoras K, Ho JC, Watts FZ, Pearl LH.

Genes Dev. 2008 Aug 1;22(15):2034-47. doi: 10.1101/gad.472808.


BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.

Sofueva S, Du LL, Limbo O, Williams JS, Russell P.

Mol Cell Biol. 2010 Oct;30(19):4732-43. doi: 10.1128/MCB.00413-10. Epub 2010 Aug 2.


Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest.

Capasso H, Palermo C, Wan S, Rao H, John UP, O'Connell MJ, Walworth NC.

J Cell Sci. 2002 Dec 1;115(Pt 23):4555-64.


Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.

Mahyous Saeyd SA, Ewert-Krzemieniewska K, Liu B, Caspari T.

Nucleic Acids Res. 2014 Jul;42(12):7734-47. doi: 10.1093/nar/gku452. Epub 2014 May 26.


Establishment of and recovery from damage checkpoint requires sequential interactions of Crb2 with protein kinases Rad3, Chk1, and Cdc2.

Esashi F, Mochida S, Matsusaka T, Obara T, Ogawa A, Tamai K, Yanagida M.

Cold Spring Harb Symp Quant Biol. 2000;65:443-9. Review. No abstract available.


Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.

Limbo O, Porter-Goff ME, Rhind N, Russell P.

Mol Cell Biol. 2011 Feb;31(3):573-83. doi: 10.1128/MCB.00994-10. Epub 2010 Nov 22.


The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner.

Lin SJ, Wardlaw CP, Morishita T, Miyabe I, Chahwan C, Caspari T, Schmidt U, Carr AM, Garcia V.

PLoS Genet. 2012 Jun;8(6):e1002801. doi: 10.1371/journal.pgen.1002801. Epub 2012 Jun 28.


APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress.

Willis J, Patel Y, Lentz BL, Yan S.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10592-7. doi: 10.1073/pnas.1301445110. Epub 2013 Jun 10.

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