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Items: 1 to 20 of 106

1.

Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity.

Lipiski M, Deuel JW, Baek JH, Engelsberger WR, Buehler PW, Schaer DJ.

Antioxid Redox Signal. 2013 Nov 10;19(14):1619-33. doi: 10.1089/ars.2012.5089. Epub 2013 Mar 28.

2.

Haptoglobin phenotypes differ in their ability to inhibit heme transfer from hemoglobin to LDL.

Bamm VV, Tsemakhovich VA, Shaklai M, Shaklai N.

Biochemistry. 2004 Apr 6;43(13):3899-906.

PMID:
15049697
3.

Quantitative mass spectrometry defines an oxidative hotspot in hemoglobin that is specifically protected by haptoglobin.

Pimenova T, Pereira CP, Gehrig P, Buehler PW, Schaer DJ, Zenobi R.

J Proteome Res. 2010 Aug 6;9(8):4061-70. doi: 10.1021/pr100252e.

PMID:
20568812
4.
5.

Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity.

Deuel JW, Vallelian F, Schaer CA, Puglia M, Buehler PW, Schaer DJ.

Free Radic Biol Med. 2015 Dec;89:931-43. doi: 10.1016/j.freeradbiomed.2015.09.016. Epub 2015 Oct 22.

6.

Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin.

Mollan TL, Jia Y, Banerjee S, Wu G, Kreulen RT, Tsai AL, Olson JS, Crumbliss AL, Alayash AI.

Free Radic Biol Med. 2014 Apr;69:265-77. doi: 10.1016/j.freeradbiomed.2014.01.030. Epub 2014 Jan 30.

7.

Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs.

Boretti FS, Buehler PW, D'Agnillo F, Kluge K, Glaus T, Butt OI, Jia Y, Goede J, Pereira CP, Maggiorini M, Schoedon G, Alayash AI, Schaer DJ.

J Clin Invest. 2009 Aug;119(8):2271-80. doi: 10.1172/JCI39115. Epub 2009 Jul 20.

8.

Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145.

Cooper CE, Schaer DJ, Buehler PW, Wilson MT, Reeder BJ, Silkstone G, Svistunenko DA, Bulow L, Alayash AI.

Antioxid Redox Signal. 2013 Jun 10;18(17):2264-73. doi: 10.1089/ars.2012.4547. Epub 2012 Aug 6.

9.

Trapping of human hemoglobin by haptoglobin: molecular mechanisms and clinical applications.

Ratanasopa K, Chakane S, Ilyas M, Nantasenamat C, Bulow L.

Antioxid Redox Signal. 2013 Jun 10;18(17):2364-74. doi: 10.1089/ars.2012.4878. Epub 2012 Oct 18. Review.

PMID:
22900934
10.

Complexity of a complex trait locus: HP, HPR, haemoglobin and cholesterol.

Guthrie PA, Rodriguez S, Gaunt TR, Lawlor DA, Smith GD, Day IN.

Gene. 2012 May 10;499(1):8-13. doi: 10.1016/j.gene.2012.03.034. Epub 2012 Mar 11.

11.

Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage.

Schaer CA, Deuel JW, Bittermann AG, Rubio IG, Schoedon G, Spahn DR, Wepf RA, Vallelian F, Schaer DJ.

Cell Death Differ. 2013 Nov;20(11):1569-79. doi: 10.1038/cdd.2013.113. Epub 2013 Aug 30.

12.

Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions.

Banerjee S, Jia Y, Siburt CJ, Abraham B, Wood F, Bonaventura C, Henkens R, Crumbliss AL, Alayash AI.

Free Radic Biol Med. 2012 Sep 15;53(6):1317-26. doi: 10.1016/j.freeradbiomed.2012.07.023. Epub 2012 Jul 27.

PMID:
22841869
13.

Haptoglobin polymorphism affects nitric oxide bioavailability in preeclampsia.

Sertório JT, Lacchini R, Amaral LM, Palei AC, Cavalli RC, Sandrim VC, Duarte G, Tanus-Santos JE.

J Hum Hypertens. 2013 Jun;27(6):349-54. doi: 10.1038/jhh.2012.57. Epub 2012 Dec 6.

PMID:
23223086
14.

Can gas replace protein function? CO abrogates the oxidative toxicity of myoglobin.

Sher EA, Sholto AY, Shaklai M, Shaklai N.

PLoS One. 2014 Aug 11;9(8):e104075. doi: 10.1371/journal.pone.0104075. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e111565.

15.

Antioxidant effect of haptoglobin phenotypes against DNA damage induced by hydrogen peroxide in human leukocytes.

Moreira LR, Miranda-Vilela AL, Silva IC, Akimoto AK, Klautau-Guimarães MN, Grisolia CK.

Genet Mol Res. 2009;8(1):284-90.

PMID:
19291877
16.

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.

Baek JH, D'Agnillo F, Vallelian F, Pereira CP, Williams MC, Jia Y, Schaer DJ, Buehler PW.

J Clin Invest. 2012 Apr;122(4):1444-58. doi: 10.1172/JCI59770. Epub 2012 Mar 26.

17.

Atherogenesis may involve the prooxidant and proinflammatory effects of ferryl hemoglobin.

Potor L, Bányai E, Becs G, Soares MP, Balla G, Balla J, Jeney V.

Oxid Med Cell Longev. 2013;2013:676425. doi: 10.1155/2013/676425. Epub 2013 May 15.

18.

Haptoglobin halts hemoglobin's havoc.

Kato GJ.

J Clin Invest. 2009 Aug;119(8):2140-2. doi: 10.1172/JCI40258. Epub 2009 Jul 20.

19.

The haptoglobin-gene deletion responsible for anhaptoglobinemia.

Koda Y, Soejima M, Yoshioka N, Kimura H.

Am J Hum Genet. 1998 Feb;62(2):245-52.

20.

Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration.

Irwin DC, Baek JH, Hassell K, Nuss R, Eigenberger P, Lisk C, Loomis Z, Maltzahn J, Stenmark KR, Nozik-Grayck E, Buehler PW.

Free Radic Biol Med. 2015 May;82:50-62. doi: 10.1016/j.freeradbiomed.2015.01.012. Epub 2015 Feb 2.

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