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Items: 1 to 20 of 99

1.

Coordinate regulation of eIF2α phosphorylation by PPP1R15 and GCN2 is required during Drosophila development.

Malzer E, Szajewska-Skuta M, Dalton LE, Thomas SE, Hu N, Skaer H, Lomas DA, Crowther DC, Marciniak SJ.

J Cell Sci. 2013 Mar 15;126(Pt 6):1406-15. doi: 10.1242/jcs.117614. Epub 2013 Feb 15.

2.

An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation.

Lee YY, Cevallos RC, Jan E.

J Biol Chem. 2009 Mar 13;284(11):6661-73. doi: 10.1074/jbc.M806735200. Epub 2009 Jan 8.

3.

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase.

Berlanga JJ, Santoyo J, De Haro C.

Eur J Biochem. 1999 Oct;265(2):754-62.

4.

Functional characterization of Drosophila melanogaster PERK eukaryotic initiation factor 2alpha (eIF2alpha) kinase.

Pomar N, Berlanga JJ, Campuzano S, Hernández G, Elías M, de Haro C.

Eur J Biochem. 2003 Jan;270(2):293-306.

5.

Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.

Young SK, Willy JA, Wu C, Sachs MS, Wek RC.

J Biol Chem. 2015 Nov 20;290(47):28257-71. doi: 10.1074/jbc.M115.693184. Epub 2015 Oct 7.

6.

Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.

Kubota H, Ota K, Sakaki Y, Ito T.

J Biol Chem. 2001 May 18;276(20):17591-6. Epub 2001 Feb 28.

7.

Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.

Chambers JE, Dalton LE, Clarke HJ, Malzer E, Dominicus CS, Patel V, Moorhead G, Ron D, Marciniak SJ.

Elife. 2015 Mar 16;4. doi: 10.7554/eLife.04872.

8.

Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2α-dependent translational attenuation and insulin biosynthesis in pancreatic β cells.

Akai R, Hosoda A, Yoshino M, Iwawaki T.

Genes Cells. 2015 Nov;20(11):871-86. doi: 10.1111/gtc.12279. Epub 2015 Aug 28.

9.
10.

An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α.

Rojas M, Vasconcelos G, Dever TE.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3466-75. doi: 10.1073/pnas.1501557112. Epub 2015 Jun 22.

11.

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development.

Harding HP, Zhang Y, Scheuner D, Chen JJ, Kaufman RJ, Ron D.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1832-7. doi: 10.1073/pnas.0809632106. Epub 2009 Jan 30.

12.

Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frame.

Fernandez J, Yaman I, Merrick WC, Koromilas A, Wek RC, Sood R, Hensold J, Hatzoglou M.

J Biol Chem. 2002 Jan 18;277(3):2050-8. Epub 2001 Oct 29.

13.

Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells.

Jousse C, Oyadomari S, Novoa I, Lu P, Zhang Y, Harding HP, Ron D.

J Cell Biol. 2003 Nov 24;163(4):767-75.

14.

Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response.

Reid DW, Tay AS, Sundaram JR, Lee IC, Chen Q, George SE, Nicchitta CV, Shenolikar S.

Mol Cell Biol. 2016 Jun 15;36(13):1868-80. doi: 10.1128/MCB.00190-16. Print 2016 Jul 1.

16.

Residues required for phosphorylation of translation initiation factor eIF2α under diverse stress conditions are divergent between yeast and human.

Majumder M, Mitchell D, Merkulov S, Wu J, Guan BJ, Snider MD, Krokowski D, Yee VC, Hatzoglou M.

Int J Biochem Cell Biol. 2015 Feb;59:135-41. doi: 10.1016/j.biocel.2014.12.004. Epub 2014 Dec 22.

17.

A truncated Danio rerio PKZ isoform functionally interacts with eIF2α and inhibits protein synthesis.

Liu ZY, Jia KT, Li C, Weng SP, Guo CJ, He JG.

Gene. 2013 Sep 15;527(1):292-300. doi: 10.1016/j.gene.2013.05.043. Epub 2013 Jun 3.

PMID:
23742890
18.

4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging.

Kang MJ, Vasudevan D, Kang K, Kim K, Park JE, Zhang N, Zeng X, Neubert TA, Marr MT 2nd, Ryoo HD.

J Cell Biol. 2017 Jan 2;216(1):115-129. doi: 10.1083/jcb.201511073. Epub 2016 Dec 15.

20.

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