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Items: 1 to 20 of 93

1.

QTL-based association analyses reveal novel genes influencing pleiotropy of metabolic syndrome (MetS).

Zhang Y, Kent JW Jr, Olivier M, Ali O, Broeckel U, Abdou RM, Dyer TD, Comuzzie A, Curran JE, Carless MA, Rainwater DL, Göring HH, Blangero J, Kissebah AH.

Obesity (Silver Spring). 2013 Oct;21(10):2099-111. doi: 10.1002/oby.20324. Epub 2013 May 29.

2.

A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation.

Zhang Y, Kent JW Jr, Olivier M, Ali O, Cerjak D, Broeckel U, Abdou RM, Dyer TD, Comuzzie A, Curran JE, Carless MA, Rainwater DL, Göring HH, Blangero J, Kissebah AH.

BMC Med Genomics. 2013 Apr 29;6:14. doi: 10.1186/1755-8794-6-14.

3.

Pleiotropic genes for metabolic syndrome and inflammation.

Kraja AT, Chasman DI, North KE, Reiner AP, Yanek LR, Kilpeläinen TO, Smith JA, Dehghan A, Dupuis J, Johnson AD, Feitosa MF, Tekola-Ayele F, Chu AY, Nolte IM, Dastani Z, Morris A, Pendergrass SA, Sun YV, Ritchie MD, Vaez A, Lin H, Ligthart S, Marullo L, Rohde R, Shao Y, Ziegler MA, Im HK; Cross Consortia Pleiotropy Group; Cohorts for Heart and; Aging Research in Genetic Epidemiology; Genetic Investigation of Anthropometric Traits Consortium; Global Lipids Genetics Consortium; Meta-Analyses of Glucose; Insulin-related traits Consortium; Global BPgen Consortium; ADIPOGen Consortium; Women's Genome Health Study; Howard University Family Study, Schnabel RB, Jørgensen T, Jørgensen ME, Hansen T, Pedersen O, Stolk RP, Snieder H, Hofman A, Uitterlinden AG, Franco OH, Ikram MA, Richards JB, Rotimi C, Wilson JG, Lange L, Ganesh SK, Nalls M, Rasmussen-Torvik LJ, Pankow JS, Coresh J, Tang W, Linda Kao WH, Boerwinkle E, Morrison AC, Ridker PM, Becker DM, Rotter JI, Kardia SL, Loos RJ, Larson MG, Hsu YH, Province MA, Tracy R, Voight BF, Vaidya D, O'Donnell CJ, Benjamin EJ, Alizadeh BZ, Prokopenko I, Meigs JB, Borecki IB.

Mol Genet Metab. 2014 Aug;112(4):317-38. doi: 10.1016/j.ymgme.2014.04.007. Epub 2014 May 9.

4.

Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.

Kristiansson K, Perola M, Tikkanen E, Kettunen J, Surakka I, Havulinna AS, Stancáková A, Barnes C, Widen E, Kajantie E, Eriksson JG, Viikari J, Kähönen M, Lehtimäki T, Raitakari OT, Hartikainen AL, Ruokonen A, Pouta A, Jula A, Kangas AJ, Soininen P, Ala-Korpela M, Männistö S, Jousilahti P, Bonnycastle LL, Järvelin MR, Kuusisto J, Collins FS, Laakso M, Hurles ME, Palotie A, Peltonen L, Ripatti S, Salomaa V.

Circ Cardiovasc Genet. 2012 Apr 1;5(2):242-9. doi: 10.1161/CIRCGENETICS.111.961482. Epub 2012 Mar 7.

5.

Polymorphisms in lipid metabolism related miRNA binding sites and risk of metabolic syndrome.

Ye Q, Zhao X, Xu K, Li Q, Cheng J, Gao Y, Du J, Shi H, Zhou L.

Gene. 2013 Oct 10;528(2):132-8. doi: 10.1016/j.gene.2013.07.036. Epub 2013 Jul 31.

PMID:
23911300
6.

Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population.

Kim YK, Hwang MY, Kim YJ, Moon S, Han S, Kim BJ.

Cardiovasc Diabetol. 2016 Feb 1;15:20. doi: 10.1186/s12933-016-0337-1.

7.

Obesity-insulin targeted genes in the 3p26-25 region in human studies and LG/J and SM/J mice.

Kraja AT, Lawson HA, Arnett DK, Borecki IB, Broeckel U, de las Fuentes L, Hunt SC, Province MA, Cheverud J, Rao DC.

Metabolism. 2012 Aug;61(8):1129-41. doi: 10.1016/j.metabol.2012.01.008. Epub 2012 Mar 3.

8.

Lack of association between LXRα and LXRβ gene polymorphisms and prevalence of metabolic syndrome: a case-control study of an Iranian population.

Rooki H, Ghayour-Mobarhan M, Haerian MS, Ebrahimi M, Azimzadeh P, Heidari-Bakavoli A, Mirfakhraei R, Tavallaie S, Mirhafez R, Ferns G, Zali MR.

Gene. 2013 Dec 15;532(2):288-93. doi: 10.1016/j.gene.2013.09.107. Epub 2013 Oct 4.

PMID:
24100084
9.

A methodology for multivariate phenotype-based genome-wide association studies to mine pleiotropic genes.

Park SH, Lee JY, Kim S.

BMC Syst Biol. 2011;5 Suppl 2:S13. doi: 10.1186/1752-0509-5-S2-S13. Epub 2011 Dec 14.

10.

Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome.

Tekola-Ayele F, Doumatey AP, Shriner D, Bentley AR, Chen G, Zhou J, Fasanmade O, Johnson T, Oli J, Okafor G, Eghan BA Jr, Agyenim-Boateng K, Adebamowo C, Amoah A, Acheampong J, Adeyemo A, Rotimi CN.

Mol Genet Metab. 2015 Dec;116(4):305-13. doi: 10.1016/j.ymgme.2015.10.008. Epub 2015 Oct 23.

11.

Integrated computational and experimental analysis of the neuroendocrine transcriptome in genetic hypertension identifies novel control points for the cardiometabolic syndrome.

Friese RS, Ye C, Nievergelt CM, Schork AJ, Mahapatra NR, Rao F, Napolitan PS, Waalen J, Ehret GB, Munroe PB, Schmid-Schönbein GW, Eskin E, O'Connor DT.

Circ Cardiovasc Genet. 2012 Aug 1;5(4):430-40. doi: 10.1161/CIRCGENETICS.111.962415. Epub 2012 Jun 5.

12.

Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome.

Kissebah AH, Sonnenberg GE, Myklebust J, Goldstein M, Broman K, James RG, Marks JA, Krakower GR, Jacob HJ, Weber J, Martin L, Blangero J, Comuzzie AG.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14478-83.

13.

Principal-component-based multivariate regression for genetic association studies of metabolic syndrome components.

Mei H, Chen W, Dellinger A, He J, Wang M, Yau C, Srinivasan SR, Berenson GS.

BMC Genet. 2010 Nov 9;11:100. doi: 10.1186/1471-2156-11-100.

14.

Multivariate linkage scan for metabolic syndrome traits in families with type 2 diabetes.

Edwards KL, Wan JY, Hutter CM, Fong PY, Santorico SA.

Obesity (Silver Spring). 2011 Jun;19(6):1235-43. doi: 10.1038/oby.2010.299. Epub 2010 Dec 23.

15.

Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a Northern European family population.

Zhang Y, Kent JW 2nd, Lee A, Cerjak D, Ali O, Diasio R, Olivier M, Blangero J, Carless MA, Kissebah AH.

BMC Med Genomics. 2013 Mar 19;6:9. doi: 10.1186/1755-8794-6-9.

16.

Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.

Min JL, Nicholson G, Halgrimsdottir I, Almstrup K, Petri A, Barrett A, Travers M, Rayner NW, Mägi R, Pettersson FH, Broxholme J, Neville MJ, Wills QF, Cheeseman J; GIANT Consortium; MolPAGE Consortium, Allen M, Holmes CC, Spector TD, Fleckner J, McCarthy MI, Karpe F, Lindgren CM, Zondervan KT.

PLoS Genet. 2012;8(2):e1002505. doi: 10.1371/journal.pgen.1002505. Epub 2012 Feb 23.

17.

A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.

Kraja AT, Vaidya D, Pankow JS, Goodarzi MO, Assimes TL, Kullo IJ, Sovio U, Mathias RA, Sun YV, Franceschini N, Absher D, Li G, Zhang Q, Feitosa MF, Glazer NL, Haritunians T, Hartikainen AL, Knowles JW, North KE, Iribarren C, Kral B, Yanek L, O'Reilly PF, McCarthy MI, Jaquish C, Couper DJ, Chakravarti A, Psaty BM, Becker LC, Province MA, Boerwinkle E, Quertermous T, Palotie L, Jarvelin MR, Becker DM, Kardia SL, Rotter JI, Chen YD, Borecki IB.

Diabetes. 2011 Apr;60(4):1329-39. doi: 10.2337/db10-1011. Epub 2011 Mar 8.

18.

Genomic structure of nucleotide diversity among Lyon rat models of metabolic syndrome.

Ma MC, Atanur SS, Aitman TJ, Kwitek AE.

BMC Genomics. 2014 Mar 14;15:197. doi: 10.1186/1471-2164-15-197.

19.

Genetic association study with metabolic syndrome and metabolic-related traits in a cross-sectional sample and a 10-year longitudinal sample of chinese elderly population.

Yang J, Liu J, Liu J, Li W, Li X, He Y, Ye L.

PLoS One. 2014 Jun 24;9(6):e100548. doi: 10.1371/journal.pone.0100548. eCollection 2014.

20.

Association of genetic variation in ENPP1 with obesity-related phenotypes.

Jenkinson CP, Coletta DK, Flechtner-Mors M, Hu SL, Fourcaudot MJ, Rodriguez LM, Schneider J, Arya R, Stern MP, Blangero J, Duggirala R, DeFronzo RA.

Obesity (Silver Spring). 2008 Jul;16(7):1708-13. doi: 10.1038/oby.2008.262. Epub 2008 May 8.

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