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Items: 1 to 20 of 168


The CORVET complex promotes tethering and fusion of Rab5/Vps21-positive membranes.

Balderhaar HJ, Lachmann J, Yavavli E, Bröcker C, Lürick A, Ungermann C.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3823-8. doi: 10.1073/pnas.1221785110. Epub 2013 Feb 15.


Functional separation of endosomal fusion factors and the class C core vacuole/endosome tethering (CORVET) complex in endosome biogenesis.

Cabrera M, Arlt H, Epp N, Lachmann J, Griffith J, Perz A, Reggiori F, Ungermann C.

J Biol Chem. 2013 Feb 15;288(7):5166-75. doi: 10.1074/jbc.M112.431536. Epub 2012 Dec 21.


The CORVET tethering complex interacts with the yeast Rab5 homolog Vps21 and is involved in endo-lysosomal biogenesis.

Peplowska K, Markgraf DF, Ostrowicz CW, Bange G, Ungermann C.

Dev Cell. 2007 May;12(5):739-50.


Membrane dynamics and fusion at late endosomes and vacuoles--Rab regulation, multisubunit tethering complexes and SNAREs.

Epp N, Rethmeier R, Krämer L, Ungermann C.

Eur J Cell Biol. 2011 Sep;90(9):779-85. doi: 10.1016/j.ejcb.2011.04.007. Epub 2011 Jun 16. Review.


The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles.

Lachmann J, Barr FA, Ungermann C.

Mol Biol Cell. 2012 Jul;23(13):2516-26. doi: 10.1091/mbc.E11-12-1030. Epub 2012 May 16.


Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole.

Rana M, Lachmann J, Ungermann C.

Mol Biol Cell. 2015 Jul 1;26(13):2535-49. doi: 10.1091/mbc.E15-02-0062. Epub 2015 May 13.


Subunit organization and Rab interactions of Vps-C protein complexes that control endolysosomal membrane traffic.

Plemel RL, Lobingier BT, Brett CL, Angers CG, Nickerson DP, Paulsel A, Sprague D, Merz AJ.

Mol Biol Cell. 2011 Apr 15;22(8):1353-63. doi: 10.1091/mbc.E10-03-0260. Epub 2011 Feb 16.


The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3.

John Peter AT, Lachmann J, Rana M, Bunge M, Cabrera M, Ungermann C.

J Cell Biol. 2013 Apr 1;201(1):97-111. doi: 10.1083/jcb.201210038.


CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion.

Balderhaar HJ, Ungermann C.

J Cell Sci. 2013 Mar 15;126(Pt 6):1307-16. doi: 10.1242/jcs.107805. Review.


The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments.

Markgraf DF, Ahnert F, Arlt H, Mari M, Peplowska K, Epp N, Griffith J, Reggiori F, Ungermann C.

Mol Biol Cell. 2009 Dec;20(24):5276-89. doi: 10.1091/mbc.E09-06-0521.


The N-terminal domains of Vps3 and Vps8 are critical for localization and function of the CORVET tethering complex on endosomes.

Epp N, Ungermann C.

PLoS One. 2013 Jun 20;8(6):e67307. doi: 10.1371/journal.pone.0067307. Print 2013.


Mapping of Vps21 and HOPS binding sites in Vps8 and effect of binding site mutants on endocytic trafficking.

Pawelec A, Arsić J, Kölling R.

Eukaryot Cell. 2010 Apr;9(4):602-10. doi: 10.1128/EC.00286-09. Epub 2010 Feb 19.


Defined subunit arrangement and rab interactions are required for functionality of the HOPS tethering complex.

Ostrowicz CW, Bröcker C, Ahnert F, Nordmann M, Lachmann J, Peplowska K, Perz A, Auffarth K, Engelbrecht-Vandré S, Ungermann C.

Traffic. 2010 Oct;11(10):1334-46. doi: 10.1111/j.1600-0854.2010.01097.x.


Class E compartments form in response to ESCRT dysfunction in yeast due to hyperactivity of the Vps21 Rab GTPase.

Russell MR, Shideler T, Nickerson DP, West M, Odorizzi G.

J Cell Sci. 2012 Nov 1;125(Pt 21):5208-20. doi: 10.1242/jcs.111310. Epub 2012 Aug 16.


A Rab5 GTPase module is important for autophagosome closure.

Zhou F, Zou S, Chen Y, Lipatova Z, Sun D, Zhu X, Li R, Wu Z, You W, Cong X, Zhou Y, Xie Z, Gyurkovska V, Liu Y, Li Q, Li W, Cheng J, Liang Y, Segev N.

PLoS Genet. 2017 Sep 21;13(9):e1007020. doi: 10.1371/journal.pgen.1007020. eCollection 2017 Sep.


Intrinsic tethering activity of endosomal Rab proteins.

Lo SY, Brett CL, Plemel RL, Vignali M, Fields S, Gonen T, Merz AJ.

Nat Struct Mol Biol. 2011 Dec 11;19(1):40-7. doi: 10.1038/nsmb.2162.


Vps9 family protein Muk1 is the second Rab5 guanosine nucleotide exchange factor in budding yeast.

Paulsel AL, Merz AJ, Nickerson DP.

J Biol Chem. 2013 Jun 21;288(25):18162-71. doi: 10.1074/jbc.M113.457069. Epub 2013 Apr 23.


A Vps21 endocytic module regulates autophagy.

Chen Y, Zhou F, Zou S, Yu S, Li S, Li D, Song J, Li H, He Z, Hu B, Björn LO, Lipatova Z, Liang Y, Xie Z, Segev N.

Mol Biol Cell. 2014 Oct 15;25(20):3166-77. doi: 10.1091/mbc.E14-04-0917. Epub 2014 Aug 20.


The HOPS/Class C Vps Complex Tethers High-Curvature Membranes via a Direct Protein-Membrane Interaction.

Ho R, Stroupe C.

Traffic. 2016 Oct;17(10):1078-90. doi: 10.1111/tra.12421. Epub 2016 Jul 15.


Live-cell imaging of Aspergillus nidulans autophagy: RAB1 dependence, Golgi independence and ER involvement.

Pinar M, Pantazopoulou A, Peñalva MA.

Autophagy. 2013 Jul;9(7):1024-43. doi: 10.4161/auto.24483. Epub 2013 Apr 8.

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