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Warfarin accelerates ectopic mineralization in Abcc6(-/-) mice: clinical relevance to pseudoxanthoma elasticum.

Li Q, Guo H, Chou DW, Harrington DJ, Schurgers LJ, Terry SF, Uitto J.

Am J Pathol. 2013 Apr;182(4):1139-50. doi: 10.1016/j.ajpath.2012.12.037. Epub 2013 Feb 15.


Magnesium carbonate-containing phosphate binder prevents connective tissue mineralization in Abcc6(-/-) mice-potential for treatment of pseudoxanthoma elasticum.

Li Q, Larusso J, Grand-Pierre AE, Uitto J.

Clin Transl Sci. 2009 Dec;2(6):398-404. doi: 10.1111/j.1752-8062.2009.00161.x.


Atorvastatin counteracts aberrant soft tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6⁻/⁻).

Guo H, Li Q, Chou DW, Uitto J.

J Mol Med (Berl). 2013 Oct;91(10):1177-84. doi: 10.1007/s00109-013-1066-5. Epub 2013 Jun 27.


The mineralization phenotype in Abcc6 ( -/- ) mice is affected by Ggcx gene deficiency and genetic background--a model for pseudoxanthoma elasticum.

Li Q, Uitto J.

J Mol Med (Berl). 2010 Feb;88(2):173-81. doi: 10.1007/s00109-009-0522-8. Epub 2009 Sep 27.


Pseudoxanthoma elasticum: reduced gamma-glutamyl carboxylation of matrix gla protein in a mouse model (Abcc6-/-).

Li Q, Jiang Q, Schurgers LJ, Uitto J.

Biochem Biophys Res Commun. 2007 Dec 14;364(2):208-13. Epub 2007 Oct 4.


Elevated dietary magnesium prevents connective tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6(-/-)).

LaRusso J, Li Q, Jiang Q, Uitto J.

J Invest Dermatol. 2009 Jun;129(6):1388-94. doi: 10.1038/jid.2008.391. Epub 2009 Jan 1.


Vitamin K does not prevent soft tissue mineralization in a mouse model of pseudoxanthoma elasticum.

Brampton C, Yamaguchi Y, Vanakker O, Van Laer L, Chen LH, Thakore M, De Paepe A, Pomozi V, Szabó PT, Martin L, Váradi A, Le Saux O.

Cell Cycle. 2011 Jun 1;10(11):1810-20. Epub 2011 Jun 1.


Pseudoxanthoma elasticum: molecular genetics and putative pathomechanisms.

Uitto J, Li Q, Jiang Q.

J Invest Dermatol. 2010 Mar;130(3):661-70. doi: 10.1038/jid.2009.411. Epub 2009 Dec 24.


Matrix gla protein and alkaline phosphatase are differently modulated in human dermal fibroblasts from PXE patients and controls.

Boraldi F, Annovi G, Vermeer C, Schurgers LJ, Trenti T, Tiozzo R, Guerra D, Quaglino D.

J Invest Dermatol. 2013 Apr;133(4):946-54. doi: 10.1038/jid.2012.460. Epub 2012 Dec 6.


Dietary magnesium, not calcium, prevents vascular calcification in a mouse model for pseudoxanthoma elasticum.

Gorgels TG, Waarsing JH, de Wolf A, ten Brink JB, Loves WJ, Bergen AA.

J Mol Med (Berl). 2010 May;88(5):467-75. doi: 10.1007/s00109-010-0596-3. Epub 2010 Feb 23.


Mouse models for pseudoxanthoma elasticum: genetic and dietary modulation of the ectopic mineralization phenotypes.

Li Q, Guo H, Chou DW, Berndt A, Sundberg JP, Uitto J.

PLoS One. 2014 Feb 19;9(2):e89268. doi: 10.1371/journal.pone.0089268. eCollection 2014.


Magnesium reduces carotid intima-media thickness in a mouse model of pseudoxanthoma elasticum: a novel treatment biomarker.

Kupetsky-Rincon EA, Li Q, Uitto J.

Clin Transl Sci. 2012 Jun;5(3):259-64. doi: 10.1111/j.1752-8062.2011.00390.x.


Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to the GGCX mutations in the PXE-like syndrome.

Vanakker OM, Martin L, Schurgers LJ, Quaglino D, Costrop L, Vermeer C, Pasquali-Ronchetti I, Coucke PJ, De Paepe A.

Lab Invest. 2010 Jun;90(6):895-905. doi: 10.1038/labinvest.2010.68. Epub 2010 Apr 5.


Pseudoxanthoma elasticum: cardiac findings in patients and Abcc6-deficient mouse model.

Prunier F, Terrien G, Le Corre Y, Apana AL, Bière L, Kauffenstein G, Furber A, Bergen AA, Gorgels TG, Le Saux O, Leftheriotis G, Martin L.

PLoS One. 2013 Jul 23;8(7):e68700. doi: 10.1371/journal.pone.0068700. Print 2013.


Vitamin K supplementation increases vitamin K tissue levels but fails to counteract ectopic calcification in a mouse model for pseudoxanthoma elasticum.

Gorgels TG, Waarsing JH, Herfs M, Versteeg D, Schoensiegel F, Sato T, Schlingemann RO, Ivandic B, Vermeer C, Schurgers LJ, Bergen AA.

J Mol Med (Berl). 2011 Nov;89(11):1125-35. doi: 10.1007/s00109-011-0782-y. Epub 2011 Jul 2.


Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues.

Klement JF, Matsuzaki Y, Jiang QJ, Terlizzi J, Choi HY, Fujimoto N, Li K, Pulkkinen L, Birk DE, Sundberg JP, Uitto J.

Mol Cell Biol. 2005 Sep;25(18):8299-310.


The effects of bisphosphonates on ectopic soft tissue mineralization caused by mutations in the ABCC6 gene.

Li Q, Sundberg JP, Levine MA, Terry SF, Uitto J.

Cell Cycle. 2015;14(7):1082-9. doi: 10.1080/15384101.2015.1007809.

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