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Trypanosoma cruzi highjacks TrkC to enter cardiomyocytes and cardiac fibroblasts while exploiting TrkA for cardioprotection against oxidative stress.

Aridgides D, Salvador R, PereiraPerrin M.

Cell Microbiol. 2013 Aug;15(8):1357-66. doi: 10.1111/cmi.12119. Epub 2013 Mar 14.


Trypanosoma cruzi coaxes cardiac fibroblasts into preventing cardiomyocyte death by activating nerve growth factor receptor TrkA.

Aridgides D, Salvador R, PereiraPerrin M.

PLoS One. 2013;8(2):e57450. doi: 10.1371/journal.pone.0057450. Epub 2013 Feb 21.


Neurotrophin receptor TrkC is an entry receptor for Trypanosoma cruzi in neural, glial, and epithelial cells.

Weinkauf C, Salvador R, Pereiraperrin M.

Infect Immun. 2011 Oct;79(10):4081-7. doi: 10.1128/IAI.05403-11. Epub 2011 Jul 25.


Parasite-derived neurotrophic factor/trans-sialidase of Trypanosoma cruzi links neurotrophic signaling to cardiac innate immune response.

Salvador R, Aridgides D, PereiraPerrin M.

Infect Immun. 2014 Sep;82(9):3687-96. doi: 10.1128/IAI.02098-14. Epub 2014 Jun 16.


Human autoantibodies specific for neurotrophin receptors TrkA, TrkB, and TrkC protect against lethal Trypanosoma cruzi infection in mice.

Lu B, Alroy J, Luquetti AO, PereiraPerrin M.

Am J Pathol. 2008 Nov;173(5):1406-14. doi: 10.2353/ajpath.2008.080514. Epub 2008 Oct 2.


Trypanosoma cruzi promotes neuronal and glial cell survival through the neurotrophic receptor TrkC.

Weinkauf C, Pereiraperrin M.

Infect Immun. 2009 Apr;77(4):1368-75. doi: 10.1128/IAI.01450-08. Epub 2009 Jan 29.


Autoantibodies to neurotrophic receptors TrkA, TrkB and TrkC in patients with acute Chagas' disease.

Lu B, Luquetti AO, Rassi A, PereiraPerrin M.

Scand J Immunol. 2010 Mar;71(3):220-5. doi: 10.1111/j.1365-3083.2009.02364.x.


Auto-antibodies to receptor tyrosine kinases TrkA, TrkB and TrkC in patients with chronic Chagas' disease.

Lu B, Petrola Z, Luquetti AO, PereiraPerrin M.

Scand J Immunol. 2008 Jun;67(6):603-9. doi: 10.1111/j.1365-3083.2008.02102.x. Epub 2008 Apr 10.


Chagas' disease parasite-derived neurotrophic factor activates cholinergic gene expression in neuronal PC12 cells.

Akpan N, Caradonna K, Chuenkova MV, PereiraPerrin M.

Brain Res. 2008 Jun 27;1217:195-202. doi: 10.1016/j.brainres.2008.03.082. Epub 2008 Apr 10.


Host and parasite apoptosis following Trypanosoma cruzi infection in in vitro and in vivo models.

de Souza EM, Araújo-Jorge TC, Bailly C, Lansiaux A, Batista MM, Oliveira GM, Soeiro MN.

Cell Tissue Res. 2003 Nov;314(2):223-35. Epub 2003 Aug 20.


Trypanosoma cruzi targets Akt in host cells as an intracellular antiapoptotic strategy.

Chuenkova MV, PereiraPerrin M.

Sci Signal. 2009 Nov 17;2(97):ra74. doi: 10.1126/scisignal.2000374.


Role for interleukin-1 beta in Trypanosoma cruzi-induced cardiomyocyte hypertrophy.

Petersen CA, Burleigh BA.

Infect Immun. 2003 Aug;71(8):4441-7.


Cardiomyocyte oxidants production may signal to T. cruzi intracellular development.

Dias PP, Capila RF, do Couto NF, Estrada D, Gadelha FR, Radi R, Piacenza L, Andrade LO.

PLoS Negl Trop Dis. 2017 Aug 23;11(8):e0005852. doi: 10.1371/journal.pntd.0005852. eCollection 2017 Aug.


Heparan sulfate proteoglycans mediate the invasion of cardiomyocytes by Trypanosoma cruzi.

Calvet CM, Toma L, De Souza FR, Meirelles Mde N, Pereira MC.

J Eukaryot Microbiol. 2003 Mar-Apr;50(2):97-103.


Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC.

Huang EJ, Wilkinson GA, Fariñas I, Backus C, Zang K, Wong SL, Reichardt LF.

Development. 1999 May;126(10):2191-203.


TGF-β receptor type II costameric localization in cardiomyocytes and host cell TGF-β response is disrupted by Trypanosoma cruzi infection.

Calvet CM, Silva TA, DE Melo TG, DE Araújo-Jorge TC, Pereira MC.

Parasitology. 2016 May;143(6):704-15. doi: 10.1017/S0031182016000299. Epub 2016 Mar 21.


Trypomastigotes and amastigotes of Trypanosoma cruzi induce apoptosis and STAT3 activation in cardiomyocytes in vitro.

Stahl P, Ruppert V, Meyer T, Schmidt J, Campos MA, Gazzinelli RT, Maisch B, Schwarz RT, Debierre-Grockiego F.

Apoptosis. 2013 Jun;18(6):653-63. doi: 10.1007/s10495-013-0822-x.


Trypanosoma cruzi Neurotrophic Factor Facilitates Cardiac Repair in a Mouse Model of Chronic Chagas Disease.

Ledoux T, Aridgides D, Salvador R, Ngwenyama N, Panagiotidou S, Alcaide P, Blanton R, Perrin MA.

J Pharmacol Exp Ther. 2018 Oct 22. pii: jpet.118.251900. doi: 10.1124/jpet.118.251900. [Epub ahead of print]

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