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Molecular determinants of binding to the Plasmodium subtilisin-like protease 1.

Fulle S, Withers-Martinez C, Blackman MJ, Morris GM, Finn PW.

J Chem Inf Model. 2013 Mar 25;53(3):573-83. doi: 10.1021/ci300581z. Epub 2013 Mar 4.


Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.

Withers-Martinez C, Suarez C, Fulle S, Kher S, Penzo M, Ebejer JP, Koussis K, Hackett F, Jirgensons A, Finn P, Blackman MJ.

Int J Parasitol. 2012 May 15;42(6):597-612. doi: 10.1016/j.ijpara.2012.04.005. Epub 2012 Apr 27.


Computational reverse-engineering of a spider-venom derived peptide active against Plasmodium falciparum SUB1.

Bastianelli G, Bouillon A, Nguyen C, Crublet E, Pêtres S, Gorgette O, Le-Nguyen D, Barale JC, Nilges M.

PLoS One. 2011;6(7):e21812. doi: 10.1371/journal.pone.0021812. Epub 2011 Jul 27.


Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.

Gemma S, Giovani S, Brindisi M, Tripaldi P, Brogi S, Savini L, Fiorini I, Novellino E, Butini S, Campiani G, Penzo M, Blackman MJ.

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5317-21. doi: 10.1016/j.bmcl.2012.06.023. Epub 2012 Jun 23.


Rational design of the first difluorostatone-based PfSUB1 inhibitors.

Giovani S, Penzo M, Brogi S, Brindisi M, Gemma S, Novellino E, Savini L, Blackman MJ, Campiani G, Butini S.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3582-6. doi: 10.1016/j.bmcl.2014.05.044. Epub 2014 May 23.


Substrate derived peptidic α-ketoamides as inhibitors of the malarial protease PfSUB1.

Kher SS, Penzo M, Fulle S, Finn PW, Blackman MJ, Jirgensons A.

Bioorg Med Chem Lett. 2014 Sep 15;24(18):4486-9. doi: 10.1016/j.bmcl.2014.07.086. Epub 2014 Aug 7.


A multifunctional serine protease primes the malaria parasite for red blood cell invasion.

Koussis K, Withers-Martinez C, Yeoh S, Child M, Hackett F, Knuepfer E, Juliano L, Woehlbier U, Bujard H, Blackman MJ.

EMBO J. 2009 Mar 18;28(6):725-35. doi: 10.1038/emboj.2009.22. Epub 2009 Feb 12.


In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound.

Bouillon A, Giganti D, Benedet C, Gorgette O, Pêtres S, Crublet E, Girard-Blanc C, Witkowski B, Ménard D, Nilges M, Mercereau-Puijalon O, Stoven V, Barale JC.

J Biol Chem. 2013 Jun 21;288(25):18561-73. doi: 10.1074/jbc.M113.456764. Epub 2013 May 7.


In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors.

Brogi S, Giovani S, Brindisi M, Gemma S, Novellino E, Campiani G, Blackman MJ, Butini S.

J Mol Graph Model. 2016 Mar;64:121-130. doi: 10.1016/j.jmgm.2016.01.005. Epub 2016 Jan 19.


Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling.

Withers-Martinez C, Saldanha JW, Ely B, Hackett F, O'Connor T, Blackman MJ.

J Biol Chem. 2002 Aug 16;277(33):29698-709. Epub 2002 Jun 6.


Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum.

Arastu-Kapur S, Ponder EL, Fonović UP, Yeoh S, Yuan F, Fonović M, Grainger M, Phillips CI, Powers JC, Bogyo M.

Nat Chem Biol. 2008 Mar;4(3):203-13. doi: 10.1038/nchembio.70. Epub 2008 Feb 3.


Independent amino acid residues in the S2 pocket of falcipain-3 determine its specificity for P2 residues in substrates.

Kolla VK, Prasad R, Sayyad Z, Atul, Shah AY, Allanki AD, Navale R, Singhal N, Tanneru N, Sudhakar R, Venkatesan V, Deshmukh MV, Sijwali PS.

Mol Biochem Parasitol. 2015 Aug;202(2):11-22. doi: 10.1016/j.molbiopara.2015.09.005. Epub 2015 Oct 9.


Proteolytic activity of Plasmodium falciparum subtilisin-like protease 3 on parasite profilin, a multifunctional protein.

Alam A, Bhatnagar RK, Relan U, Mukherjee P, Chauhan VS.

Mol Biochem Parasitol. 2013 Oct;191(2):58-62. doi: 10.1016/j.molbiopara.2013.09.006. Epub 2013 Sep 27.


Engagement of the S1, S1' and S2' subsites drives efficient catalysis of peptide bond hydrolysis by the M1-family aminopeptidase from Plasmodium falciparum.

Dalal S, Ragheb DR, Klemba M.

Mol Biochem Parasitol. 2012 May;183(1):70-7. doi: 10.1016/j.molbiopara.2012.02.003. Epub 2012 Feb 13.


Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution.

Tsunemi M, Matsuura Y, Sakakibara S, Katsube Y.

Biochemistry. 1996 Sep 10;35(36):11570-6.


Computational design of protein-based inhibitors of Plasmodium vivax subtilisin-like 1 protease.

Bastianelli G, Bouillon A, Nguyen C, Le-Nguyen D, Nilges M, Barale JC.

PLoS One. 2014 Oct 24;9(10):e109269. doi: 10.1371/journal.pone.0109269. eCollection 2014.


The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.

Withers-Martinez C, Strath M, Hackett F, Haire LF, Howell SA, Walker PA, Christodoulou E, Dodson GG, Blackman MJ.

Nat Commun. 2014 May 2;5:3726. doi: 10.1038/ncomms4726. Erratum in: Nat Commun. 2014;5:4031. Evangelos, Christodoulou [corrected to Christodoulou, Evangelos].


Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide.

Wang G, MacRaild CA, Mohanty B, Mobli M, Cowieson NP, Anders RF, Simpson JS, McGowan S, Norton RS, Scanlon MJ.

PLoS One. 2014 Oct 24;9(10):e109674. doi: 10.1371/journal.pone.0109674. eCollection 2014.


Cleavage specificity of the subtilisin-like protease C1 from soybean.

Boyd PM, Barnaby N, Tan-Wilson A, Wilson KA.

Biochim Biophys Acta. 2002 Apr 29;1596(2):269-82.


Expression and characterization of catalytic domain of Plasmodium falciparum subtilisin-like protease 3.

Alam A, Bhatnagar RK, Chauhan VS.

Mol Biochem Parasitol. 2012 May;183(1):84-9. doi: 10.1016/j.molbiopara.2011.12.009. Epub 2012 Jan 20.

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