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Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels.

Li H, Dhanasekaran P, Alexander ET, Rader DJ, Phillips MC, Lund-Katz S.

Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):687-93. doi: 10.1161/ATVBAHA.112.301193. Epub 2013 Feb 14.


Molecular basis for the differences in lipid and lipoprotein binding properties of human apolipoproteins E3 and E4.

Nguyen D, Dhanasekaran P, Nickel M, Nakatani R, Saito H, Phillips MC, Lund-Katz S.

Biochemistry. 2010 Dec 28;49(51):10881-9. doi: 10.1021/bi1017655. Epub 2010 Dec 3.


Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis.

Huang Y, Ji ZS, Brecht WJ, Rall SC Jr, Taylor JM, Mahley RW.

Arterioscler Thromb Vasc Biol. 1999 Dec;19(12):2952-9.


Contributions of the carboxyl-terminal helical segment to the self-association and lipoprotein preferences of human apolipoprotein E3 and E4 isoforms.

Sakamoto T, Tanaka M, Vedhachalam C, Nickel M, Nguyen D, Dhanasekaran P, Phillips MC, Lund-Katz S, Saito H.

Biochemistry. 2008 Mar 4;47(9):2968-77. doi: 10.1021/bi701923h. Epub 2008 Jan 18.


Apolipoprotein E isoforms and lipoprotein metabolism.

Phillips MC.

IUBMB Life. 2014 Sep;66(9):616-23. doi: 10.1002/iub.1314. Review.


Evidence for differential effects of apoE3 and apoE4 on HDL metabolism.

Hopkins PC, Huang Y, McGuire JG, Pitas RE.

J Lipid Res. 2002 Nov;43(11):1881-9.


Influence of domain stability on the properties of human apolipoprotein E3 and E4 and mouse apolipoprotein E.

Nguyen D, Dhanasekaran P, Nickel M, Mizuguchi C, Watanabe M, Saito H, Phillips MC, Lund-Katz S.

Biochemistry. 2014 Jun 24;53(24):4025-33.


Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice.

Altenburg M, Arbones-Mainar J, Johnson L, Wilder J, Maeda N.

Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1104-10. doi: 10.1161/ATVBAHA.108.164863. Epub 2008 Mar 27.


Molecular mechanism of apolipoprotein E binding to lipoprotein particles.

Nguyen D, Dhanasekaran P, Phillips MC, Lund-Katz S.

Biochemistry. 2009 Apr 7;48(13):3025-32. doi: 10.1021/bi9000694.


Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice.

Fitz NF, Cronican AA, Saleem M, Fauq AH, Chapman R, Lefterov I, Koldamova R.

J Neurosci. 2012 Sep 19;32(38):13125-36.


Structural differences between apolipoprotein E3 and E4 as measured by (19)F NMR.

Garai K, Mustafi SM, Baban B, Frieden C.

Protein Sci. 2010 Jan;19(1):66-74. doi: 10.1002/pro.283.


Fluorescence study of domain structure and lipid interaction of human apolipoproteins E3 and E4.

Mizuguchi C, Hata M, Dhanasekaran P, Nickel M, Okuhira K, Phillips MC, Lund-Katz S, Saito H.

Biochim Biophys Acta. 2014 Dec;1841(12):1716-24.


Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4.

Vezeridis AM, Drosatos K, Zannis VI.

J Lipid Res. 2011 Jan;52(1):45-56. doi: 10.1194/jlr.M008409. Epub 2010 Sep 22. Erratum in: J Lipid Res. 2011 Jun;52(6):1303.


Preliminary evaluation of a self-complementary AAV2/8 vector for hepatic gene transfer of human apoE3 to inhibit atherosclerotic lesion development in apoE-deficient mice.

Osman E, Evans V, Graham IR, Athanasopoulos T, McIntosh J, Nathwani AC, Simons JP, Dickson G, Owen JS.

Atherosclerosis. 2009 May;204(1):121-6. doi: 10.1016/j.atherosclerosis.2008.08.043. Epub 2008 Sep 11.


Apolipoprotein E2 (Lys146-->Gln) causes hypertriglyceridemia due to an apolipoprotein E variant-specific inhibition of lipolysis of very low density lipoproteins-triglycerides.

de Beer F, van Dijk KW, Jong MC, van Vark LC, van der Zee A, Hofker MH, Fallaux FJ, Hoeben RC, Smelt AH, Havekes LM.

Arterioscler Thromb Vasc Biol. 2000 Jul;20(7):1800-6.


Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia.

van den Maagdenberg AM, Hofker MH, Krimpenfort PJ, de Bruijn I, van Vlijmen B, van der Boom H, Havekes LM, Frants RR.

J Biol Chem. 1993 May 15;268(14):10540-5.


Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders.

Mahley RW.

J Mol Med (Berl). 2016 Jul;94(7):739-46. doi: 10.1007/s00109-016-1427-y. Epub 2016 Jun 9. Review.


Effect of apoE genotype and dietary quercetin on blood lipids and TNF-alpha levels in apoE3 and apoE4 targeted gene replacement mice.

Boesch-Saadatmandi C, Wolffram S, Minihane AM, Rimbach G.

Br J Nutr. 2009 May;101(10):1440-3. doi: 10.1017/S0007114508102434. Epub 2008 Nov 6.


Postprandial apoE isoform and conformational changes associated with VLDL lipolysis products modulate monocyte inflammation.

den Hartigh LJ, Altman R, Hutchinson R, Petrlova J, Budamagunta MS, Tetali SD, Lagerstedt JO, Voss JC, Rutledge JC.

PLoS One. 2012;7(11):e50513. doi: 10.1371/journal.pone.0050513. Epub 2012 Nov 28.

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