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Items: 1 to 20 of 136

1.

Two 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones as new non-purine xanthine oxidase inhibitors and anti-inflammatory agents.

Smelcerovic A, Rangelov M, Smelcerovic Z, Veljkovic A, Cherneva E, Yancheva D, Nikolic GM, Petronijevic Z, Kocic G.

Food Chem Toxicol. 2013 May;55:493-7. doi: 10.1016/j.fct.2013.01.052. Epub 2013 Feb 11.

PMID:
23410588
2.

Xanthine oxidase inhibitory properties and anti-inflammatory activity of 2-amino-5-alkylidene-thiazol-4-ones.

Smelcerovic Z, Veljkovic A, Kocic G, Yancheva D, Petronijevic Z, Anderluh M, Smelcerovic A.

Chem Biol Interact. 2015 Mar 5;229:73-81. doi: 10.1016/j.cbi.2015.01.022. Epub 2015 Jan 22.

PMID:
25619642
3.

Effects on MC3T3-E1 Cells and In silico Toxicological Study of Two 6-(Propan-2-yl)-4-methyl-morpholine-2,5-diones.

Vukelić-Nikolić M, Kolarevć A, Tomović K, Yancheva D, Cherneva E, Najman S, Smelcerović A.

Nat Prod Commun. 2015 Aug;10(8):1423-6.

PMID:
26434133
4.

Stimulatory effect on rat thymocytes proliferation and antimicrobial activity of two 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones.

Pavlovic V, Djordjevic A, Cherneva E, Yancheva D, Smelcerovic A.

Food Chem Toxicol. 2012 Mar;50(3-4):761-6. doi: 10.1016/j.fct.2011.11.032. Epub 2011 Nov 26.

PMID:
22138252
5.

Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase.

Takano Y, Hase-Aoki K, Horiuchi H, Zhao L, Kasahara Y, Kondo S, Becker MA.

Life Sci. 2005 Mar 4;76(16):1835-47. Epub 2005 Jan 18.

PMID:
15698861
6.

Synthesis, antioxidant, and xanthine oxidase inhibitory activities of 5-[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione derivatives.

Begum AB, Begum M, Ranganatha VL, Prashanth T, Zameer F, Hegdekatte R, Khanum SA.

Arch Pharm (Weinheim). 2014 Apr;347(4):247-55. doi: 10.1002/ardp.201300319. Epub 2013 Dec 16.

PMID:
24343903
7.

Design and synthesis of novel 2-(indol-5-yl)thiazole derivatives as xanthine oxidase inhibitors.

Song JU, Choi SP, Kim TH, Jung CK, Lee JY, Jung SH, Kim GT.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1254-8. doi: 10.1016/j.bmcl.2015.01.055. Epub 2015 Jan 30.

PMID:
25704891
8.

Synthesis, biological evaluation, and molecular docking of N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl}-benzamide/amide derivatives as xanthine oxidase and tyrosinase inhibitors.

Bandgar BP, Adsul LK, Chavan HV, Shringare SN, Korbad BL, Jalde SS, Lonikar SV, Nile SH, Shirfule AL.

Bioorg Med Chem. 2012 Sep 15;20(18):5649-57. doi: 10.1016/j.bmc.2012.07.001. Epub 2012 Jul 10.

PMID:
22901670
9.

2-styrylchromones as novel inhibitors of xanthine oxidase. A structure-activity study.

Fernandes E, Carvalho F, Silva AM, Santos CM, Pinto DC, Cavaleiro JA, Bastos Mde L.

J Enzyme Inhib Med Chem. 2002 Feb;17(1):45-8.

PMID:
12365460
10.

Novel insights into the inhibitory mechanism of kaempferol on xanthine oxidase.

Wang Y, Zhang G, Pan J, Gong D.

J Agric Food Chem. 2015 Jan 21;63(2):526-34. doi: 10.1021/jf505584m. Epub 2015 Jan 7.

PMID:
25539132
11.

6-(Propan-2-yl)-3-methyl-morpholine-2,5-dione, a novel cyclodidepsipeptide with modulatory effect on rat thymocytes.

Pavlovic V, Cherneva E, Yancheva D, Smelcerovic A.

Food Chem Toxicol. 2012 Sep;50(9):3014-8. doi: 10.1016/j.fct.2012.06.004. Epub 2012 Jun 13.

PMID:
22705328
12.

6-(N-benzoylamino)purine as a novel and potent inhibitor of xanthine oxidase: inhibition mechanism and molecular modeling studies.

Tamta H, Thilagavathi R, Chakraborti AK, Mukhopadhyay AK.

J Enzyme Inhib Med Chem. 2005 Aug;20(4):317-24.

PMID:
16206825
13.

In Vitro Antioxidant Activity of Two 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones.

Stankov-Jovanovic V, Tabet JC, Dzodic P, Daskalova L, Cherneva E, Yancheva D, Smelcerovic A.

Acta Chim Slov. 2012 Dec;59(4):939-43.

PMID:
24061379
14.

Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives.

Sathisha KR, Khanum SA, Chandra JN, Ayisha F, Balaji S, Marathe GK, Gopal S, Rangappa KS.

Bioorg Med Chem. 2011 Jan 1;19(1):211-20. doi: 10.1016/j.bmc.2010.11.034. Epub 2010 Nov 18.

PMID:
21163661
15.

Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase.

Flemmig J, Kuchta K, Arnhold J, Rauwald HW.

Phytomedicine. 2011 May 15;18(7):561-6. doi: 10.1016/j.phymed.2010.10.021. Epub 2010 Dec 8.

PMID:
21144719
16.

Effect of luteolin on xanthine oxidase: inhibition kinetics and interaction mechanism merging with docking simulation.

Yan J, Zhang G, Hu Y, Ma Y.

Food Chem. 2013 Dec 15;141(4):3766-73. doi: 10.1016/j.foodchem.2013.06.092. Epub 2013 Jun 28.

PMID:
23993547
17.

Discovery of novel xanthone derivatives as xanthine oxidase inhibitors.

Hu L, Hu H, Wu W, Chai X, Luo J, Wu Q.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):4013-5. doi: 10.1016/j.bmcl.2011.04.140. Epub 2011 May 6.

PMID:
21620698
18.

Biochemical characterization of some pyrazolopyrimidine-based inhibitors of xanthine oxidase.

Tamta H, Kalra S, Mukhopadhyay AK.

Biochemistry (Mosc). 2006;71 Suppl 1:S49-54.

19.

A rational approach for the design and synthesis of 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles as a new class of potential non-purine xanthine oxidase inhibitors.

Nepali K, Singh G, Turan A, Agarwal A, Sapra S, Kumar R, Banerjee UC, Verma PK, Satti NK, Gupta MK, Suri OP, Dhar KL.

Bioorg Med Chem. 2011 Mar 15;19(6):1950-8. doi: 10.1016/j.bmc.2011.01.058. Epub 2011 Feb 23.

PMID:
21353569
20.

An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).

Ojha R, Singh J, Ojha A, Singh H, Sharma S, Nepali K.

Expert Opin Ther Pat. 2017 Mar;27(3):311-345. doi: 10.1080/13543776.2017.1261111. Epub 2016 Nov 28. Review.

PMID:
27841045

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