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Items: 1 to 20 of 107


In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors.

Ratliff M, Alter S, Frasca D, Blomberg BB, Riley RL.

Aging Cell. 2013 Apr;12(2):303-11. doi: 10.1111/acel.12055.


In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells.

Ratliff M, Alter S, McAvoy K, Frasca D, Wright JA, Zinkel SS, Khan WN, Blomberg BB, Riley RL.

Aging Cell. 2015 Jun;14(3):382-90. doi: 10.1111/acel.12302. Epub 2015 Feb 27.


Migration of immature and mature B cells in the aged microenvironment.

Wols HA, Johnson KM, Ippolito JA, Birjandi SZ, Su Y, Le PT, Witte PL.

Immunology. 2010 Feb;129(2):278-90. doi: 10.1111/j.1365-2567.2009.03182.x. Epub 2009 Oct 21.


Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice.

Frasca D, Nguyen D, Riley RL, Blomberg BB.

J Immunol. 2003 Jan 15;170(2):719-26.


B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2.

Winkler IG, Bendall LJ, Forristal CE, Helwani F, Nowlan B, Barbier V, Shen Y, Cisterne A, Sedger LM, Levesque JP.

Haematologica. 2013 Mar;98(3):325-33. doi: 10.3324/haematol.2012.069260. Epub 2012 Aug 28.


Age-associated B cells (ABC) inhibit B lymphopoiesis and alter antibody repertoires in old age.

Riley RL, Khomtchouk K, Blomberg BB.

Cell Immunol. 2017 Apr 26. pii: S0008-8749(17)30064-3. doi: 10.1016/j.cellimm.2017.04.008. [Epub ahead of print]


Expression of CD28 by bone marrow stromal cells and its involvement in B lymphopoiesis.

Gray Parkin K, Stephan RP, Apilado RG, Lill-Elghanian DA, Lee KP, Saha B, Witte PL.

J Immunol. 2002 Sep 1;169(5):2292-302.


B-cell lymphopoiesis is regulated by cathepsin L.

Badano MN, Camicia GL, Lombardi G, Maglioco A, Cabrera G, Costa H, Meiss RP, Piazzon I, Nepomnaschy I.

PLoS One. 2013 Apr 9;8(4):e61347. doi: 10.1371/journal.pone.0061347. Print 2013.


NK cells in the CD19- B220+ bone marrow fraction are increased in senescence and reduce E2A and surrogate light chain proteins in B cell precursors.

King AM, Keating P, Prabhu A, Blomberg BB, Riley RL.

Mech Ageing Dev. 2009 Jun;130(6):384-92. doi: 10.1016/j.mad.2009.03.002. Epub 2009 Mar 24.


T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis.

Bockstal V, Guirnalda P, Caljon G, Goenka R, Telfer JC, Frenkel D, Radwanska M, Magez S, Black SJ.

PLoS Pathog. 2011 Jun;7(6):e1002089. doi: 10.1371/journal.ppat.1002089. Epub 2011 Jun 30.


Old mice retain bone marrow B1 progenitors, but lose B2 precursors, and exhibit altered immature B cell phenotype and light chain usage.

Alter-Wolf S, Blomberg BB, Riley RL.

Mech Ageing Dev. 2009 Jun;130(6):401-8. doi: 10.1016/j.mad.2009.04.001. Epub 2009 Apr 9.


Cutting edge: BAFF regulates CD21/35 and CD23 expression independent of its B cell survival function.

Gorelik L, Cutler AH, Thill G, Miklasz SD, Shea DE, Ambrose C, Bixler SA, Su L, Scott ML, Kalled SL.

J Immunol. 2004 Jan 15;172(2):762-6. Erratum in: J Immunol. 2004 Apr 1;172(7):4646.


Generation of functionally distinct B lymphocytes from common myeloid progenitors.

Yang GX, Lian ZX, Chuang YH, Shu SA, Moritoki Y, Lan R, Wakabayashi K, Ansari AA, Dorshkind K, Ikehara S, Gershwin ME.

Clin Exp Immunol. 2007 Nov;150(2):349-57. Epub 2007 Sep 5.


The tumor promoter and NF-κB modulator Bcl-3 regulates splenic B cell development.

Zhang X, Paun A, Claudio E, Wang H, Siebenlist U.

J Immunol. 2013 Dec 15;191(12):5984-92. doi: 10.4049/jimmunol.1300611. Epub 2013 Nov 15.


Connective tissue growth factor is expressed in bone marrow stromal cells and promotes interleukin-7-dependent B lymphopoiesis.

Cheung LC, Strickland DH, Howlett M, Ford J, Charles AK, Lyons KM, Brigstock DR, Goldschmeding R, Cole CH, Alexander WS, Kees UR.

Haematologica. 2014 Jul;99(7):1149-56. doi: 10.3324/haematol.2013.102327. Epub 2014 Apr 11.


Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7.

Huntington ND, Labi V, Cumano A, Vieira P, Strasser A, Villunger A, Di Santo JP, Alves NL.

Int Immunol. 2009 Jun;21(6):715-25. doi: 10.1093/intimm/dxp043. Epub 2009 May 19.

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