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Items: 1 to 20 of 115

1.

Allo-network drugs: extension of the allosteric drug concept to protein- protein interaction and signaling networks.

Szilágyi A, Nussinov R, Csermely P.

Curr Top Med Chem. 2013;13(1):64-77. Review.

PMID:
23409766
2.
3.

Allo-network drugs: harnessing allostery in cellular networks.

Nussinov R, Tsai CJ, Csermely P.

Trends Pharmacol Sci. 2011 Dec;32(12):686-93. doi: 10.1016/j.tips.2011.08.004. Epub 2011 Sep 16.

PMID:
21925743
4.

Emerging paradigms in GPCR allostery: implications for drug discovery.

Wootten D, Christopoulos A, Sexton PM.

Nat Rev Drug Discov. 2013 Aug;12(8):630-44. doi: 10.1038/nrd4052. Review.

PMID:
23903222
5.

Allosteric drugs and seven transmembrane receptors.

Kenakin T.

Curr Top Med Chem. 2013;13(1):5-13.

PMID:
23409762
6.

Harnessing allostery: a novel approach to drug discovery.

Lu S, Li S, Zhang J.

Med Res Rev. 2014 Nov;34(6):1242-85. doi: 10.1002/med.21317. Epub 2014 May 14. Review.

PMID:
24827416
7.

From Protein Communication to Drug Discovery.

Persico M, Di Dato A, Orteca N, Fattorusso C, Novellino E, Andreoli M, Ferlini C.

Curr Top Med Chem. 2015;15(20):2019-31. Review.

PMID:
25986690
8.

Allosteric sites can be identified based on the residue-residue interaction energy difference.

Ma X, Qi Y, Lai L.

Proteins. 2015 Aug;83(8):1375-84. doi: 10.1002/prot.24681.

PMID:
25185787
9.

Allostery in disease and in drug discovery.

Nussinov R, Tsai CJ.

Cell. 2013 Apr 11;153(2):293-305. doi: 10.1016/j.cell.2013.03.034. Review.

10.

Molecular alliance-from orthosteric and allosteric ligands to dualsteric/bitopic agonists at G protein coupled receptors.

Mohr K, Schmitz J, Schrage R, Tränkle C, Holzgrabe U.

Angew Chem Int Ed Engl. 2013 Jan 7;52(2):508-16. doi: 10.1002/anie.201205315. Epub 2012 Dec 6. Review.

PMID:
23225228
11.

The different ways through which specificity works in orthosteric and allosteric drugs.

Nussinov R, Tsai CJ.

Curr Pharm Des. 2012;18(9):1311-6.

PMID:
22316155
12.

Using NMR to Develop New Allosteric and Allo-Network Drugs.

Smith RE, Tran K, Richards KM, Luo R.

Curr Drug Discov Technol. 2015;12(4):193-204.

PMID:
26577663
13.

Druggable orthosteric and allosteric hot spots to target protein-protein interactions.

Ma B, Nussinov R.

Curr Pharm Des. 2014;20(8):1293-301. Review.

PMID:
23713780
14.

The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors.

Valant C, Robert Lane J, Sexton PM, Christopoulos A.

Annu Rev Pharmacol Toxicol. 2012;52:153-78. doi: 10.1146/annurev-pharmtox-010611-134514. Epub 2011 Sep 9. Review.

PMID:
21910627
15.

Conformational ensembles, signal transduction and residue hot spots: application to drug discovery.

Acuner Ozbabacan SE, Gursoy A, Keskin O, Nussinov R.

Curr Opin Drug Discov Devel. 2010 Sep;13(5):527-37. Review.

PMID:
20812144
16.

Protein contact network topology: a natural language for allostery.

Di Paola L, Giuliani A.

Curr Opin Struct Biol. 2015 Apr;31:43-8. doi: 10.1016/j.sbi.2015.03.001. Epub 2015 Mar 18. Review.

PMID:
25796032
17.

Trapping moving targets with small molecules.

Lee GM, Craik CS.

Science. 2009 Apr 10;324(5924):213-5. doi: 10.1126/science.1169378.

18.

Allosteric communication occurs via networks of tertiary and quaternary motions in proteins.

Daily MD, Gray JJ.

PLoS Comput Biol. 2009 Feb;5(2):e1000293. doi: 10.1371/journal.pcbi.1000293. Epub 2009 Feb 20.

19.

Emerging Computational Methods for the Rational Discovery of Allosteric Drugs.

Wagner JR, Lee CT, Durrant JD, Malmstrom RD, Feher VA, Amaro RE.

Chem Rev. 2016 Jun 8;116(11):6370-90. doi: 10.1021/acs.chemrev.5b00631. Epub 2016 Apr 13. Review.

20.

The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs.

Hudson BD, Ulven T, Milligan G.

Curr Top Med Chem. 2013;13(1):14-25. Review.

PMID:
23409763

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